Indirect Measurement of Respiratory Quotient in Unipulmonary Ventilation.

NCT03751605 | Completed

• 1 other identifier: PI2018_843_0047
• Study Type: observational
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

The measurement of VO2 and VCO2 makes it possible to calculate the respiratory quotient (RQ) (VCO2 / VO2) which is a reflection of human energy metabolism and therefore of anaerobiosis. A study has been conducted in our department to demonstrate the ability of the indirectly measured respiratory quotient (RQ) from the inspired and exhaled breath analysis of the anesthetic respirator to predict the onset of anaerobic metabolism and postoperative complications in the operating room. Unipulmonary ventilation is the rule in thoracic surgery: it improves surgical exposure and protects the operated lung. However, no study has examined the impact of these mechanisms on the indirect measurement of RQ in unipulmonary ventilation. The main objective of our work is to validate indirect RQ measurement during unipulmonary ventilation. The secondary objective was to assess the predictability of postoperative complications of indirect QR.

Conditions

Respiratory Quotient Measurement

Keywords

unipulmonary ventilation, complications, respiratory quotient.

Outcome Measures

Primary Outcomes (1)

• Indirect respiratory quotient

  during surgery

Secondary Outcomes (1)

• occurrence of at least one post-operative complication

  through study completion, an average of 6 months

Interventions

unipulmonary ventilation PROCEDURE

observational study based on the computation of respiratory quotient in patient cohort treated by unipulmonary ventilation in routine thoracic surgery

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Inclusion Criteria: * Age\>18 years old * Adults admitted to the operating room for thoracic surgery requiring unipulmonary ventilation Exclusion Criteria: * Cardiac surgery * Laparoscopy * Preoperative oxygen therapy

You may qualify if:

• Age\>18 years old
• Adults admitted to the operating room for thoracic surgery requiring unipulmonary ventilation

You may not qualify if:

• Cardiac surgery
• Laparoscopy
• Preoperative oxygen therapy

Sponsors & Collaborators

• Centre Hospitalier Universitaire, Amiens: lead

Study Sites (1)

CHU Amiens

Amiens, 80054, France

Location

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 8, 2018
• First Posted: November 23, 2018
• Study Start: November 1, 2018
• Primary Completion: May 1, 2019
• Study Completion: February 1, 2023
• Last Updated: March 1, 2023

Record last verified: 2023-02

Locations

FR (1)