Effect of Molecular Hydrogen Inhalation on Metabolic Response During Low-intensity Exercise on a Bicycle Ergometer

NCT06951789 | Enrolling By Invitation

• 1 other identifier: FTK_2024_101
• Study Type: interventional
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

This trial evaluates the effect of molecular hydrogen inhalation on metabolic response, heart rate, and rating of perceived exertion in healthy females during 30 minutes of exercise on a bicycle ergometer.

Conditions

Healthy; Respiratory Quotient Measurement

Outcome Measures

Primary Outcomes (1)

• Respiratory exchange ratio

  Respiratory exchange ratio is measured with Ergostik analyser (Geratherm Respiratory, Bad Kissinger, Germany) breath by breath during the session and averaged over 5 min windows for subsequent analysis.

  Change after 1 week of crossover.

Secondary Outcomes (4)

• Ventilation

  Change after 1 week of crossover.

• Oxygen uptake

  Change after 1 week of crossover.

• Heart rate

  Change after 1 week of crossover.

• Rating of perceived exertion

  Change after 1 week of crossover.

Other Outcomes (1)

• Oxygen saturation

  Change after 1 week of crossover.

Study Arms (2)

Molecular hydrogen

EXPERIMENTAL

Molecular hydrogen inhalation for 20 min at rest and 30 min during exercise.

Other: Molecular hydrogen

Placebo

PLACEBO COMPARATOR

Placebo inhalation for 20 min at rest and 30 min during exercise.

Other: Placebo

Interventions

Molecular hydrogen OTHER

Hydrogen gas, purity \>99.9%, flow rate 600 ml/min (two generators 300 ml/min each).

Also known as: i300 Hydrogen Generator, H2 World Health & Beauty Company, Ostrava, Czech Republic

Molecular hydrogen

Placebo OTHER

Ambient air, flow rate 600 ml/min (two pumps 300 ml/min each).

Also known as: i300 Hydrogen Generator (placebo), H2 World Health & Beauty Company, Ostrava, Czech Republic

Placebo

Eligibility Criteria

• Age: 18 Years - 35 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Free of major diseases.
• Signed informed consent.

You may not qualify if:

• Acute conditions contraindicating laboratory testing of exercise.
• Cardiorespiratory disease.
• Pharmacotherapy affecting metabolism.
• Musculoskeletal problems.

Sponsors & Collaborators

• Palacky University: lead

Study Sites (1)

Palacky University, Faculty of Physical Culture

Olomouc, Czech Republic, 77111, Czechia

Location

MeSH Terms

Interventions

Hydrogen

Intervention Hierarchy (Ancestors)

Elements; Inorganic Chemicals; Gases

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant professor

Study Record Dates

• First Submitted: April 23, 2025
• First Posted: April 30, 2025
• Study Start: May 5, 2025
• Primary Completion: July 1, 2025
• Study Completion: July 1, 2025
• Last Updated: May 8, 2025

Record last verified: 2025-05

Data Sharing

• IPD Sharing: Will share
• Time Frame: Beginning 1 month after the publication of results with no end date.

Locations

CZ (1)