NCT03749694

Brief Summary

The aim of the study was to use data from the Myocardial Ischaemia National Audit Project (MINAP) to investigate whether temporal improvements in survival were associated with changes in patients' baseline clinical risk or use of guideline-indicated treatments for the management of STEMI, and to determine the extent to which associations explained the temporal improvements in survival.

Trial Health

100
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
232,353

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Jan 2004

Longer than P75 for all trials

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 1, 2004

Completed
9.5 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 30, 2013

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

June 30, 2013

Completed
5.4 years until next milestone

First Submitted

Initial submission to the registry

November 20, 2018

Completed
1 day until next milestone

First Posted

Study publicly available on registry

November 21, 2018

Completed
Last Updated

November 21, 2018

Status Verified

November 1, 2018

Enrollment Period

9.5 years

First QC Date

November 20, 2018

Last Update Submit

November 20, 2018

Conditions

Acute Myocardial Infarction

Keywords

Acute Myocardial Infarctionmortalityevidence-based careMyocardial Ischaemia National Audit ProjectST-elevation myocardial infarction

Outcome Measures

Primary Outcomes (1)

  • All cause mortality

    one year

Secondary Outcomes (1)

  • All cause mortality

    six months

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

The study population comprised of 232,353 in hospital survivors of ST-elevation myocardial infarction recorded in the Myocardial Ischaemia National Audit Project registry between 2004 and June 2013.

You may qualify if:

  • aged 18 years or more
  • patients hospitalised with ST-elevation myocardial infarction

You may not qualify if:

  • patients hospitalised with phenotypes other than ST-elevation myocardial infarction

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Related Publications (1)

  • Dondo TB, Hall M, Munyombwe T, Wilkinson C, Yadegarfar ME, Timmis A, Batin PD, Jernberg T, Fox KA, Gale CP. A nationwide causal mediation analysis of survival following ST-elevation myocardial infarction. Heart. 2020 May;106(10):765-771. doi: 10.1136/heartjnl-2019-315760. Epub 2019 Nov 15.

    PMID: 31732655DERIVED

MeSH Terms

Conditions

ST Elevation Myocardial Infarction

Condition Hierarchy (Ancestors)

Myocardial InfarctionMyocardial IschemiaHeart DiseasesCardiovascular DiseasesVascular DiseasesInfarctionIschemiaPathologic ProcessesPathological Conditions, Signs and SymptomsNecrosis

Study Officials

  • Chris P Gale, FRCP

    University of Leeds

    PRINCIPAL INVESTIGATOR

  • Tatendashe B Dondo, PhD

    University of Leeds

    PRINCIPAL INVESTIGATOR

  • Marlous Hall, PhD

    University of Leeds

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Target Duration
7 Years
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Postdoctoral medical statistician

Study Record Dates

First Submitted

November 20, 2018

First Posted

November 21, 2018

Study Start

January 1, 2004

Primary Completion

June 30, 2013

Study Completion

June 30, 2013

Last Updated

November 21, 2018

Record last verified: 2018-11

Data Sharing

IPD Sharing
Will not share