NCT02786654

Brief Summary

The aim of the study is to investigate the association between the use of β blockers and mortality among hospital survivors of acute myocardial infarction without heart failure.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
179,810

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Jan 2007

Longer than P75 for all trials

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 1, 2007

Completed
6.4 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 1, 2013

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

June 1, 2013

Completed
3 years until next milestone

First Submitted

Initial submission to the registry

May 26, 2016

Completed
6 days until next milestone

First Posted

Study publicly available on registry

June 1, 2016

Completed
Last Updated

June 18, 2019

Status Verified

June 1, 2019

Enrollment Period

6.4 years

First QC Date

May 26, 2016

Last Update Submit

June 14, 2019

Conditions

Acute Myocardial Infarction

Keywords

Acute myocardial infarctionmortalityevidence-based careMyocardial Ischaemia National Audit Projectβ blockers

Outcome Measures

Primary Outcomes (1)

  • All cause mortality

    1 year

Secondary Outcomes (2)

  • All cause mortality

    6 months

  • All cause mortality

    30 days

Eligibility Criteria

Age18 Years - 100 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

The study population comprised of 179,810 in hospital survivors of acute myocardial infarction without heart failure recorded in the Myocardial Ischaemia National Audit Project registry between 2007 and June 2013

You may qualify if:

  • acute myocardial infarction patients only
  • aged 18 to 100 years

You may not qualify if:

  • other final diagnosis besides acute myocardial infarction
  • died in-hospital
  • patients with missing mortality data
  • aged \> 100
  • patients with previous acute myocardial infarction or angina
  • patients who have received coronary interventions before
  • patients with heart failure
  • patients with β blocker prior use
  • patients contraindicated for β blocker use
  • patients with use of a loop diuretic

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

University of Leeds

Leeds, LS2 9JT, United Kingdom

Location

Related Publications (1)

  • Dondo TB, Hall M, West RM, Jernberg T, Lindahl B, Bueno H, Danchin N, Deanfield JE, Hemingway H, Fox KAA, Timmis AD, Gale CP. beta-Blockers and Mortality After Acute Myocardial Infarction in Patients Without Heart Failure or Ventricular Dysfunction. J Am Coll Cardiol. 2017 Jun 6;69(22):2710-2720. doi: 10.1016/j.jacc.2017.03.578.

    PMID: 28571635BACKGROUND

Study Officials

  • Chris P Gale, FRCP

    University of Leeds

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Target Duration
6 Years
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Research assistant

Study Record Dates

First Submitted

May 26, 2016

First Posted

June 1, 2016

Study Start

January 1, 2007

Primary Completion

June 1, 2013

Study Completion

June 1, 2013

Last Updated

June 18, 2019

Record last verified: 2019-06

Data Sharing

IPD Sharing
Will not share

Locations

GB(1)