Bone Marrow Cells in Myocardial Infarction
Effects of Autologous Bone Marrow Celss on Acute ST-Elevation Myocardial Infarction
1 other identifier
interventional
100
1 country
1
Brief Summary
This study is aimed to assess the effect of bone marrow cells on arrhythmia risk variables in patients with a acute myocardial infarction.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for phase_2
Started Jan 2005
Typical duration for phase_2
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
January 1, 2005
CompletedFirst Submitted
Initial submission to the registry
August 10, 2006
CompletedFirst Posted
Study publicly available on registry
August 15, 2006
CompletedPrimary Completion
Last participant's last visit for primary outcome
November 1, 2007
CompletedStudy Completion
Last participant's last visit for all outcomes
November 1, 2007
CompletedJanuary 9, 2008
December 1, 2007
2.8 years
August 10, 2006
December 27, 2007
Conditions
Keywords
Outcome Measures
Primary Outcomes (3)
Arrhythmia risk variables
left ventricular function
restenosis assessed by IVUS
Secondary Outcomes (1)
exercise tolerance
Interventions
Eligibility Criteria
You may qualify if:
- Acute ST-elevation myocardial infarction treated with thrombolytic therapy
You may not qualify if:
- Indication for rescue PCI, severe clinical heart failure, age \<18 years
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
University of Oulu
Oulu, 90220, Finland
Related Publications (3)
Miettinen JA, Salonen RJ, Niemela M, Kervinen K, Saily M, Koistinen P, Savolainen ER, Ukkonen H, Pietila M, Airaksinen KE, Knuuti J, Makikallio TH, Huikuri HV, Ylitalo KV. Effects of intracoronary infusion of bone marrow-derived stem cells on pulmonary artery pressure and diastolic function after myocardial infarction. Int J Cardiol. 2010 Dec 3;145(3):631-3. doi: 10.1016/j.ijcard.2010.09.064. Epub 2010 Oct 20. No abstract available.
PMID: 20961630DERIVEDMiettinen JA, Ylitalo K, Hedberg P, Jokelainen J, Kervinen K, Niemela M, Saily M, Koistinen P, Savolainen ER, Ukkonen H, Pietila M, Airaksinen KE, Knuuti J, Vuolteenaho O, Makikallio TH, Huikuri HV. Determinants of functional recovery after myocardial infarction of patients treated with bone marrow-derived stem cells after thrombolytic therapy. Heart. 2010 Mar;96(5):362-7. doi: 10.1136/hrt.2009.171694. Epub 2009 Nov 11.
PMID: 19910293DERIVEDHuikuri HV, Kervinen K, Niemela M, Ylitalo K, Saily M, Koistinen P, Savolainen ER, Ukkonen H, Pietila M, Airaksinen JK, Knuuti J, Makikallio TH; FINCELL Investigators. Effects of intracoronary injection of mononuclear bone marrow cells on left ventricular function, arrhythmia risk profile, and restenosis after thrombolytic therapy of acute myocardial infarction. Eur Heart J. 2008 Nov;29(22):2723-32. doi: 10.1093/eurheartj/ehn436. Epub 2008 Oct 9.
PMID: 18845667DERIVED
Study Officials
- PRINCIPAL INVESTIGATOR
Heikki V Huikuri, Professor
University of Oulu
Study Design
- Study Type
- interventional
- Phase
- phase 2
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
Study Record Dates
First Submitted
August 10, 2006
First Posted
August 15, 2006
Study Start
January 1, 2005
Primary Completion
November 1, 2007
Study Completion
November 1, 2007
Last Updated
January 9, 2008
Record last verified: 2007-12