NCT03746600

Brief Summary

While advances in medication have led to greatly improved outcomes for people living with HIV/AIDS, less than one-third of all people living with the disease are adherent enough to their medication to achieve viral suppression. Alcohol consumption has been shown to have a significant effect on HIV medication adherence, so the proposed research will aim to reduce alcohol use among people living with HIV/AIDS through a technology-driven intervention. This eight-session intervention will be delivered using a combination of videoconferencing, smart phones, and Bluetooth-enabled breathalyzers for monitoring of alcohol consumption, with an overall goal of reducing alcohol use, mitigating adherence issues, and achieving optimal prevention and treatment responses for people living with HIV/AIDS.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
50

participants targeted

Target at P25-P50 for not_applicable

Timeline
Completed

Started May 2020

Typical duration for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

September 24, 2018

Completed
2 months until next milestone

First Posted

Study publicly available on registry

November 19, 2018

Completed
1.5 years until next milestone

Study Start

First participant enrolled

May 23, 2020

Completed
3 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 7, 2023

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

June 7, 2023

Completed
1.2 years until next milestone

Results Posted

Study results publicly available

August 9, 2024

Completed
Last Updated

August 9, 2024

Status Verified

August 1, 2024

Enrollment Period

3 years

First QC Date

September 24, 2018

Results QC Date

June 5, 2024

Last Update Submit

August 7, 2024

Conditions

Keywords

HIV/AIDSAlcohol DrinkingMedication Adherence

Outcome Measures

Primary Outcomes (3)

  • Change in Problematic Alcohol Use

    Alcohol Use Disorders Identification Test-C (AUDIT-C): A validated, self-report instrument assessing problematic alcohol use. For this 3-item scale, scores range from 0-12. Higher values represent greater problematic alcohol use. Change= Week 8 score - Baseline score

    Baseline, 8-week post-test

  • Change in Daily Alcohol Consumption

    Single item asking how many days in the past month participants consumed alcohol. Responses range from 0-31. Change= Days reported at 8 weeks - Days reported at baseline

    Baseline (T1), Immediate follow-up at 8 weeks (T2)

  • Average Percent Change in Positive Breathalyzer Readings

    Participants completed up to 14 breathalyzer readings/week obtained by BACTrack mobile breathalyzer. This outcome compares average % of positive breathalyzer readings (breathalyzer values \> 0.00) per participant at Week 1 to Week 8. Numbers should be converted to percentages to aid in interpretation (e.g., -0.10 corresponds to a 10% decrease).

    Week 1 and Week 8 of the active intervention period

Secondary Outcomes (4)

  • Percent Change in HIV/AIDS Medication Adherence

    Baseline, 8-week post-test

  • Change in CD4 Count

    Baseline, 8-week post-test, 16-week follow-up

  • Change in Viral Load

    Baseline, 8-week post-test, 16-week follow-up

  • Percent Change in Daily HIV/AIDS Medication Adherence

    Week 1 and Week 8 of the active intervention period

Other Outcomes (6)

  • Change in Depressive Symptomology

    Baseline, 8-week post-test, 16-week follow-up

  • Change in Anxiety Symptoms

    Baseline, 8-week post-test, 16-week follow-up

  • Change in Self-Reported Quality of Life

    Baseline, 8-week post-test, 16-week follow-up

  • +3 more other outcomes

Study Arms (2)

Immediate Intervention Group

EXPERIMENTAL

Receives the eight-week intervention, "Project TRAC: Tracking and Reducing Alcohol Consumption," immediately upon enrollment. This intervention focuses on skill building and motivational enhancement for reducing alcohol consumption.

Behavioral: Project TRAC: Tracking and Reducing Alcohol Consumption

Waitlist Control Group

OTHER

Receives the "Project TRAC: Tracking and Reducing Alcohol Consumption" alcohol reduction intervention after an 8-week, assessment-only period. This 8-wek intervention focuses on skill building and motivational enhancement for reducing alcohol consumption.

Behavioral: Project TRAC: Tracking and Reducing Alcohol Consumption

Interventions

The TRAC intervention for people living with HIV/AIDS focuses on increasing motivation and building skills for avoiding triggers and managing situations that encourage alcohol consumption. It requires eight 30-minute sessions with a counselor using videoconferencing and mobile phones. In addition to receiving the eight sessions of intervention content, participants will complete smart phone-based self-monitoring of medication adherence and alcohol consumption, which will be discussed during intervention sessions.

Immediate Intervention GroupWaitlist Control Group

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • HIV-positive
  • years or older
  • At-risk drinker
  • Currently prescribed HIV medication
  • Current patient at the study recruitment site(s)

You may not qualify if:

  • Less than 18 years old
  • Non-English Speaking

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Atlanta Veterans Health Care System

Decatur, Georgia, 30033, United States

Location

Related Publications (1)

  • Lauckner C, Adatorwovor R, Taylor E, Sesenu F, Tanner T, Whitmire A, Marconi V, Kershaw T, Hansen N. The tracking and reducing alcohol consumption (TRAC) intervention for veterans living with HIV/AIDS: results from a pilot randomized waitlist-controlled trial. Addict Sci Clin Pract. 2025 Dec 3;21(1):1. doi: 10.1186/s13722-025-00631-5.

MeSH Terms

Conditions

Acquired Immunodeficiency SyndromeAlcohol DrinkingMedication Adherence

Interventions

EthanolEconomics

Condition Hierarchy (Ancestors)

HIV InfectionsBlood-Borne InfectionsCommunicable DiseasesInfectionsSexually Transmitted Diseases, ViralSexually Transmitted DiseasesLentivirus InfectionsRetroviridae InfectionsRNA Virus InfectionsVirus DiseasesSlow Virus DiseasesGenital DiseasesUrogenital DiseasesImmunologic Deficiency SyndromesImmune System DiseasesDrinking BehaviorBehaviorPatient CompliancePatient Acceptance of Health CareTreatment Adherence and ComplianceHealth Behavior

Intervention Hierarchy (Ancestors)

AlcoholsOrganic ChemicalsHealth Care Economics and Organizations

Results Point of Contact

Title
Carolyn Lauckner, PhD
Organization
University of Kentucky College of Medicine

Study Officials

  • Carolyn Lauckner, PhD

    University of Kentucky

    PRINCIPAL INVESTIGATOR

Publication Agreements

PI is Sponsor Employee
No
Restrictive Agreement
No

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
PARALLEL
Model Details: Randomized waitlist-controlled trial
Sponsor Type
OTHER
Responsible Party
SPONSOR INVESTIGATOR
PI Title
Assistant Professor

Study Record Dates

First Submitted

September 24, 2018

First Posted

November 19, 2018

Study Start

May 23, 2020

Primary Completion

June 7, 2023

Study Completion

June 7, 2023

Last Updated

August 9, 2024

Results First Posted

August 9, 2024

Record last verified: 2024-08

Data Sharing

IPD Sharing
Will not share

We will not share data due to: 1) the sensitive nature of the data (small sample size and information about HIV status of participants) and 2) the fact that these preliminary data will be used to inform a larger randomized controlled trial.

Locations