POC Analysis of IO Blood Samples Within Critically Ill Patients

NCT03746496 | Completed DMC

• 1 other identifier: 1234567890
• Study Type: observational
• Target: 35
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to investigate whether point-of-care (POC) analysis of intraosseous (IO) blood samples from critically ill emergency patients are accurate enough for emergency decision making, in comparison with arterial point-of-care samples.

Conditions

Critically Ill

Keywords

intraosseous; blood gas analysis; emergency medicine; critically ill; point-of-care

Outcome Measures

Primary Outcomes (1)

• agreement between intraosseous (IO) and arterial POC analyses

  agreement analysed with Bland-Altman method from IO and arterial blood samples, which have been analysed with iSTAT point-of care analyser for following parameters: Hb, pH, BE, HCO3, pO2, pCO2, glucose, Na, K, iCa

  Samples are analysed immediately after the sample has been taken. Statistical analysis about the agreement performed when the whole data has been collected.

Study Arms (1)

pre-hospital emergency patients

Patient in a need of an IO-access. Patient in a need of point-of-care laboratory analysis. Over 18 years. Alive (no Cardiac arrest.)

Diagnostic Test: point-of-care laboratory analysis

Interventions

point-of-care laboratory analysis DIAGNOSTIC_TEST

POC analysis with i-STAT POC analyser from the intraosseous and arterial blood

pre-hospital emergency patients

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Emergency patients, which are met by the helicopter emergency unit during their normal tasks

You may qualify if:

• need for point-of-care analysis
• need for intraosseous access

You may not qualify if:

• cardiac arrest
• ability to understand the consent issues in Finnish, Swedish or English

Sponsors & Collaborators

• Helsinki University Central Hospital: lead
• FinnHEMS Oy: collaborator

Study Sites (1)

FinnHEMS10, Emergency Medicine and Services, Helsinki University Hospital

Vantaa, Finland

Location

Related Publications (5)

• Jousi M, Laukkanen-Nevala P, Nurmi J. Analysing blood from intraosseous access: a systematic review. Eur J Emerg Med. 2019 Apr;26(2):77-85. doi: 10.1097/MEJ.0000000000000569.

  PMID: 30124518 RESULT

• Jousi M, Saikko S, Nurmi J. Intraosseous blood samples for point-of-care analysis: agreement between intraosseous and arterial analyses. Scand J Trauma Resusc Emerg Med. 2017 Sep 11;25(1):92. doi: 10.1186/s13049-017-0435-4.

  PMID: 28893316 RESULT

• Backman S, Angerman-Haasmaa S, Jousi M, Siitonen S, Salmela K. ABO and D typing and alloantibody screening in marrow samples: relevance to intraosseous blood transfusion. Transfusion. 2018 Jun;58(6):1372-1376. doi: 10.1111/trf.14557. Epub 2018 Mar 1.

  PMID: 29492974 RESULT

• Tallman CI, Darracq M, Young M. Analysis of intraosseous blood samples using an EPOC point of care analyzer during resuscitation. Am J Emerg Med. 2017 Mar;35(3):499-501. doi: 10.1016/j.ajem.2016.12.005. Epub 2016 Dec 12.

  PMID: 27998615 RESULT

• Veldhoen ES, de Vooght KM, Slieker MG, Versluys AB, Turner NM. Analysis of bloodgas, electrolytes and glucose from intraosseous samples using an i-STAT((R)) point-of-care analyser. Resuscitation. 2014 Mar;85(3):359-63. doi: 10.1016/j.resuscitation.2013.12.002. Epub 2013 Dec 31.

  PMID: 24389357 RESULT

MeSH Terms

Conditions

Critical Illness

Condition Hierarchy (Ancestors)

Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Jouni Nurmi, M.D. Ph D

  University of Helsinki, Helsinki University hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Target Duration: 2 Months
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Docent

Study Record Dates

• First Submitted: September 27, 2018
• First Posted: November 19, 2018
• Study Start: May 3, 2017
• Primary Completion: January 29, 2019
• Study Completion: January 29, 2019
• Last Updated: March 8, 2019

Record last verified: 2019-03

Data Sharing

• IPD Sharing: Will not share

Locations

FI (1)