HES and NICOR Data Linkage for Cardiac Failure Population Analysis

NCT03733665 | Unknown

• 1 other identifier: DARS-NIC-174209-R8G8N-v0
• Study Type: observational
• Target: 80,000
• Locations: 1 country
• Sites: 1

Brief Summary

This study is a population-based, patient-level analysis of heart failure in England over a 5-year period using a dataset created by linking HES and NICOR databases. Our analyses will look into the re-occurrence of hospitalisation after the initial diagnosis of heart failure, the influence of population factors on risk of re-hospitalisation, and the resultant cost implications in an NHS environment.

Conditions

Heart Failure; Registries; Patient Readmission

Keywords

Hospital Episode Statistics; HES; National Institute for Cardiovascular Outcomes Research; NICOR; National Heart Failure Audit

Outcome Measures

Primary Outcomes (1)

• Readmission

  Any repeat hospitalisation for heart failure

  2012-2017

Study Arms (1)

Heart failure patients

All patients in NICOR's National Heart Failure Audit will be matched to those in NHS Digital's HES database who have a 4-character primary diagnosis of I50.0-I50.9.

Other: Patients admitted to hospital

Interventions

Patients admitted to hospital OTHER

Data is captured in HES for all patient interactions with the NHS (each episode) in England. All patients admitted for heart failure have data captured in the National Heart Failure Audit.

Heart failure patients

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Acute decompensated heart failure (ADHF) is a sudden worsening of the signs and symptoms of heart failure, which typically includes difficulty breathing (dyspnoea) and leg oedema. ADHF is a common and potentially serious cause of acute respiratory distress. Treatment of ADHF consists of reducing the excess fluid retention with diuretics along with improving heart function with pharmacological treatment. Although pharmacological treatments exist for heart failure patients with reduced ejection fraction (ACE inhibitors, beta-blockers), a substantial fraction of patients exhibit preserved ejection fraction where treatment consists solely of management of comorbidities and symptoms.

You may qualify if:

• patients \>17 years old
• individual patient data appears on both HES and NICOR databases
• character primary diagnosis codes I50.0-I50.9

You may not qualify if:

• patient requests withdrawal from analyses

Sponsors & Collaborators

• King's College London: lead

Study Sites (1)

King's College London

London, United Kingdom

Location

Related Links

• Privacy notice and patient notification information

MeSH Terms

Conditions

Heart Failure

Condition Hierarchy (Ancestors)

Heart Diseases; Cardiovascular Diseases

Study Officials

• Anastasia Chalkidou

  King's College London

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: OTHER
• Target Duration: 5 Years
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 6, 2018
• First Posted: November 7, 2018
• Study Start: November 6, 2018
• Primary Completion: October 31, 2020
• Study Completion: December 31, 2020
• Last Updated: February 20, 2020

Record last verified: 2020-02

Data Sharing

• IPD Sharing: Will not share

Locations

GB (1)