Inflammation in Vascular Disease
REBEL
The Role of Inflammation in Vascular Disease (Inflammationens Roll i kärlsjukdom)
1 other identifier
observational
170
1 country
1
Brief Summary
Increasing evidence suggests that systemic low-grade inflammation may be a driving force of cardiometabolic complications, such as vascular dysfunction, atherosclerosis and ischemic heart disease. Thus, we will investigate the role of inflammation in cardiovascular disease.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started Sep 2019
Longer than P75 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
November 5, 2018
CompletedFirst Posted
Study publicly available on registry
November 6, 2018
CompletedStudy Start
First participant enrolled
September 2, 2019
CompletedPrimary Completion
Last participant's last visit for primary outcome
February 1, 2026
CompletedStudy Completion
Last participant's last visit for all outcomes
February 1, 2027
ExpectedMay 6, 2025
May 1, 2025
6.4 years
November 5, 2018
May 5, 2025
Conditions
Outcome Measures
Primary Outcomes (1)
Inflammatory status
The inflammatory status will be studied in patients with atherosclerotic disease.
2019-2024
Study Arms (2)
Control patients
Control patients (n=20): In individuals undergoing vascular surgery that is not associated with vascular disease (e.g. knee replacement surgery, trauma, etc), a piece of healthy vessel must sometimes be removed in order to facilitate the surgical process. The vessel biopsies from this group will be categorized as "healthy vessels" in our study.
Study patients
Study patients (n=150): In individuals undergoing vascular surgery associated with peripheral arterial diseases, aneurysm and/or other manifestations of atherosclerosis, vascular tissue is sometimes excised to facilitate the surgery. Biopsies from these individuals will be categorized as "vessels with vascular dysfunction".
Eligibility Criteria
Consecutive patients planned for vascular reconstruction surgery at our center.
You may qualify if:
- Patient is planned to undergo vascular surgery.
- Signed informed consent has been obtained from the patient.
You may not qualify if:
- Patient has difficulty to understand information.
- Patients under 18 years of age.
- Patients participating in any drug-related study.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
University of Gothenburg
Gothenburg, Vastragotaland, 40530, Sweden
Biospecimen
Vascular tissue.
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- STUDY DIRECTOR
Jan Boren, MD, PhD
The University of Gothenburg
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
November 5, 2018
First Posted
November 6, 2018
Study Start
September 2, 2019
Primary Completion
February 1, 2026
Study Completion (Estimated)
February 1, 2027
Last Updated
May 6, 2025
Record last verified: 2025-05