Prevalence of Cerebral Micro-bleeds in Patients With Cerebrovascular Stroke

NCT03701412 | Unknown

• 1 other identifier: POCMIPWCVS
• Study Type: observational
• Target: 50
• Locations: 0 countries
• Sites: N/A

Brief Summary

Cerebral microbleed (CMB) refers to small, round dark-signal lesions detected by T2\*-weighted or gradient-echo (GRE) magnetic resonance imaging (MRI) ..CMBs were introduced to stroke physicians in the late 1990s and early 2000s after development of MRI techniques sensitive to paramagnetic effects The clinical significance of CMBs has been actively investigated, especially in the stroke field and more recently in studies on cognitive impairment, vascular dementia and later developement of cerebral hge ..Histological investigation has shown that CMBs are tiny foci containing hemosiderin-laden macrophages and abnormal microvessels . Clinical cases with frank symptoms caused by CMBs are uncommon, Because CMBs are manifestations of focal extravascular leakage of blood components, however, investigators have suggested that accumulation of CMBs reflects a bleeding-prone status in individuals with an elevated risk of cerebral hemorrhage. Clinical studies have found strong associations between CMBs and chronic hypertension and low cholesterol levels and between the proximity and volume of CMBs and those of subsequent intracerebral hemorrhage (ICH) . studies have found that CMBs are linked to subsequent hemorrhagic stroke in stroke survivors,and suggested that CMBs are related to antithrombotic-related hemorrhage.

Conditions

Cerebrovascular Stroke

Outcome Measures

Primary Outcomes (1)

• analyse Risk factors responsible for development of cerebral micro bleeds.

  All patients will undergo T2\*-weighted or gradient-echo (GRE) magnetic resonance imaging (MRI) for detection of micro bleeds

  1 year

Interventions

MRI RADIATION

MRI brain

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

patients fulfilling previous criteria will undergo T2\*-weighted or gradient-echo (GRE) magnetic resonance imaging (MRI) for detection of microbleeds,

You may qualify if:

• Patients diagnosed as ischemic CVS or Transient ischemic attack admitted to Assuit University Hospital or visiting outpatient clinic.
• Old stroke patients on double antiplatelet therapy for duration more than 3 months
• old stroke patients on anticoagulants.

You may not qualify if:

• Patients with blood diseases hepatic and renal patient. Patients with cerebral hemorrhage.

Sponsors & Collaborators

• Assiut University: lead

MeSH Terms

Conditions

Stroke

Condition Hierarchy (Ancestors)

Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: principle investigator

Study Record Dates

• First Submitted: October 8, 2018
• First Posted: October 10, 2018
• Study Start: January 1, 2019
• Primary Completion: January 1, 2020
• Study Completion: December 31, 2021
• Last Updated: November 14, 2018

Record last verified: 2018-11