Role of MRI Diffusion in Differentiation Between Benign and Malignant Bony Lesions

NCT03463291 | Unknown

• 1 other identifier: MRIBMBL
• Study Type: observational
• Target: 50
• Locations: 0 countries
• Sites: N/A

Brief Summary

Bone tumors are categorized according to their tissue of origin into cartilagenous, osteogenic, fibrogenic, fibrohistiocytic, haematopoietic, vascular, and lipogenic tumors. Magnetic resonance imaging (MRI) is now indispensable for the preoperative workup and therapeutic follow-up of patients with musculoskeletal tumors. The application of DW-MRI in bone marrow is today an established examination technique that provides a unique contrast and that can help in the detection of bone-marrow pathologies and the differentiation of benign and malignant bone-marrow lesions. Diffusion MRI provides quantitative and qualitative assessments of tissue cellularity and cell-membrane integrity. It is widely used for tumour detection, characterisation, and monitoring during treatment. Diffusion MRI supplies functional information that complements the structural evaluation. In combination with standard structural MRI parameters, the ADC value improves tumour characterization. Diffusion MRI can also be used to monitor tumours during chemotherapy. Tumour necrosis results in loss of cell membrane integrity and in expansion of the extracellular compartment, leading to greater water-molecule diffusion with an increase in the ADC value.

Conditions

Efficacy of MRI Diffusion in Differentiation Between Benign and Malignant Bony Lesions

Outcome Measures

Primary Outcomes (1)

• The ADC value of MRI diffusion in benign and malignant bony lesions ( considering ADC value <1.2 ..malignant while ADC>1.2 ..benign)

  1 day

Study Arms (1)

Study group

All patients with bony lesions

Device: MRI

Interventions

MRI DEVICE

* T1 weighted image. * Fast spin-echoT2 weighted image. * Short inversion recovery (STIR). * T1-fat suppressed images. * Diffusion weighted sequences with different b values 0-1000 s/mm2 with qualitative assessments by the different b values as well as quantitative assessment by measurement of the ADC values.

Study group

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients will be recruited outpatient clinic of Assiut General hospital and Assiut university hospital.

You may qualify if:

• All patients with bony lesions will be included in the study.

You may not qualify if:

• Patient with cardiac pacemaker.
• Patients with metallic prosthesis in the region of examination.
• Patients with claustrophobia.
• Patient with recent history of surgical or imagining guided biopsy from the bony lesion.

Sponsors & Collaborators

• Assiut University: lead

Central Study Contacts

Amr M Attia

CONTACT

+201270092886; hexen_22us@yahoo.com

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: principal investigator

Study Record Dates

• First Submitted: March 6, 2018
• First Posted: March 13, 2018
• Study Start: May 1, 2018
• Primary Completion: May 1, 2020
• Study Completion: July 1, 2020
• Last Updated: March 13, 2018

Record last verified: 2018-03