The Use of MRI Apparent Diffusion Coefficient Value (ADC Value) to Assess Liver Cirrhosis

NCT03456440 | Unknown

• 1 other identifier: ADC value and cirrhotic liver
• Study Type: observational
• Target: 30
• Locations: 0 countries
• Sites: N/A

Brief Summary

Hepatitis is known to induce severe liver diseases. The evaluation of the severity of liver cirrhosis is very important for the selection of appropriate treatment plan and the monitoring of patient response to treatment, accurate staging of liver fibrosis is critical because it determines the indication of antiviral treatment and prognosis of patients with chronic viral hepatitis, DWI is a particularly appealing method for the diagnosis of liver fibrosis because it is easy to implement and process, without the need for contrast agents. Apparent diffusion coefficient (ADC) has been shown to be a promising marker of fibrosis and cirrhosis.

Conditions

Hepatitis C

Outcome Measures

Primary Outcomes (1)

• changes of MRI ADC value to assess early liver cirrhosis.

  Hepatitis C patients With child pugh's classification A as Assessed by MRI ADC value changes.

  30 minutes

Study Arms (2)

hepatitis C child pugh's class A

patients are examined with MRI

Diagnostic Test: MRI

normal individuals

controls cases are examined with MRI

Diagnostic Test: MRI

Interventions

MRI DIAGNOSTIC_TEST

MRI scan of the patients liver with DWI and acquisition of ADC value.

hepatitis C child pugh's class A; normal individuals

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients will be recruited from outpatient clinic of radiology department of Assiut university hospital.

You may qualify if:

• Hepatitis C positive patients with Child-Pugh (A) classification.

You may not qualify if:

• Advanced liver cirrhosis with decompensated liver or patients with malignant hepatic focal lesions.
• Cases with proven structural abnormalities, history of liver disease or risk factors of liver disease will be excluded from healthy controls.

Sponsors & Collaborators

• Assiut University: lead

MeSH Terms

Conditions

Hepatitis C

Condition Hierarchy (Ancestors)

Blood-Borne Infections; Communicable Diseases; Infections; Hepatitis, Viral, Human; Virus Diseases; Flaviviridae Infections; RNA Virus Infections; Hepatitis; Liver Diseases; Digestive System Diseases

Study Officials

• sherif abd elal, MD

  Assiut university lecturer

  STUDY DIRECTOR

Central Study Contacts

magdy adel, MBBBCh

CONTACT

01147850388; j_no3man@hotmail.com

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: principal investigator

Study Record Dates

• First Submitted: February 23, 2018
• First Posted: March 7, 2018
• Study Start: April 1, 2019
• Primary Completion: March 1, 2020
• Study Completion: May 1, 2020
• Last Updated: March 7, 2018

Record last verified: 2018-03