More Relaxation by Deep Breath on Methacholine

NCT03696602 | Completed

• 1 other identifier: enf4327
• Study Type: observational
• Target: 78
• Locations: 0 countries
• Sites: N/A

Brief Summary

Deep inhalation (DI) dilates normal airway precontracted with methacholine. The fact that this effect is diminished or absent in asthma could be explained by the presence of bronchial inflammation. The hypothesis tested was that DI induces more relaxation in methacholine induced bronchoconstriction-solely determined by the smooth muscle contraction-than in exercise induced bronchoconstriction, which is contributed to by both smooth muscle contraction and airway wall inflammation.

Conditions

Childhood Asthma

Keywords

airway smooth muscle, asthma, bronchial test, lung function

Outcome Measures

Primary Outcomes (1)

• Grs change between before deep breath and after deep breath in exercise and metacholine groups

  GrsDI represents Grs measured after deep breath reported to Grs before deep breath (bronchial provocation test)

  through study completion, an average of 1 hour

Study Arms (2)

test with methacholine

Diagnostic Test: bronchial provocation test

test with exercise

Diagnostic Test: bronchial provocation test

Interventions

bronchial provocation test DIAGNOSTIC_TEST

test with exercise; test with methacholine

Eligibility Criteria

• Age: 6 Years - 14 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17)
• Sampling Method: Probability Sample

Study Population

Seventy-three asthmatic children (48 boys) were selected, 37 underwent exercise challenge and 36 methacholine.

You may qualify if:

• Children referred to the lung function department by their pediatric pulmonologist.
• Asthma defined by a complaint of wheezing, cough and dyspnoea.
• Positive response to methacholine or exercise challenge.
• Bronchodilator medications discontinued at least 12 h prior to the testing
• Provocation allowed when the child had been free of respiratory symptoms for at least 2 weeks and baseline FEV1 larger than 70% pred.

You may not qualify if:

• \- Other respiratory diseases than asthma

Sponsors & Collaborators

• Central Hospital, Nancy, France: lead

MeSH Terms

Conditions

Asthma

Interventions

Bronchial Provocation Tests

Condition Hierarchy (Ancestors)

Bronchial Diseases; Respiratory Tract Diseases; Lung Diseases, Obstructive; Lung Diseases; Respiratory Hypersensitivity; Hypersensitivity, Immediate; Hypersensitivity; Immune System Diseases

Intervention Hierarchy (Ancestors)

Respiratory Function Tests; Diagnostic Techniques, Respiratory System; Diagnostic Techniques and Procedures; Diagnosis

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 21, 2018
• First Posted: October 4, 2018
• Study Start: July 1, 2006
• Primary Completion: June 30, 2016
• Study Completion: September 30, 2016
• Last Updated: October 4, 2018

Record last verified: 2018-09