Study Stopped
lack of funding
lncRNA-based Nomogram to Assist Childhood Asthma Diagnosis
LncRNA and Predictive Model to Improve the Early Diagnosis of Childhood Asthma
1 other identifier
observational
N/A
0 countries
N/A
Brief Summary
Asthma is the most common chronic disease in children, however, underdiagnosis of childhood asthma is an important issue in asthma management. The lack of reliable and objective diagnostic indicators requires the development of rapid and accurate strategies for the early diagnosis of childhood asthma. Recent studies have found a correlation between long-chain non-coding RNA (lncRNA) expression and childhood asthma, suggesting that lncRNA may be a potential biomarker for asthma diagnosis.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
Started Dec 2021
Shorter than P25 for all trials
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
August 21, 2020
CompletedFirst Posted
Study publicly available on registry
August 25, 2020
CompletedStudy Start
First participant enrolled
December 31, 2021
CompletedPrimary Completion
Last participant's last visit for primary outcome
September 30, 2022
CompletedStudy Completion
Last participant's last visit for all outcomes
September 30, 2022
CompletedDecember 9, 2022
December 1, 2022
9 months
August 21, 2020
December 7, 2022
Conditions
Outcome Measures
Primary Outcomes (1)
rate of early diagnosis of childhood asthma
a diagnosis of transient wheeze or asthma was made by a pediatric pulmonologist. This classification was based on symptoms, use of asthma medication, and lung function features.
24 months
Study Arms (1)
It's just an observational study, no interventions
children with recurrent wheezing
Eligibility Criteria
Children with recurrent wheezing who apply to Department of Respiratory Medicine, Children's Hospital of Fudan University.
You may qualify if:
- children with recurrent wheezing
You may not qualify if:
- diagnosis of other chronic respiratory disease (e.g. cystic fibrosis, bronchopulmonary dysplasia, etc)
- immunodeficiency- acquired or congenital
- neuromuscular disease
- congenital heart disease
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Biospecimen
peripheral blood
Study Officials
- STUDY DIRECTOR
Liling Qian, PhD.
Children's Hospital of Fudan University
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
August 21, 2020
First Posted
August 25, 2020
Study Start
December 31, 2021
Primary Completion
September 30, 2022
Study Completion
September 30, 2022
Last Updated
December 9, 2022
Record last verified: 2022-12
Data Sharing
- IPD Sharing
- Will not share
The investigators do not currently have an individual participant data sharing plan. However, de-identified research data/documents may be shared in the future with other investigators who share similar research interests. Specimens and data will not be released without (1) PI written permission and (2) appropriate Institutional Review Board (IRB) approval. Data use and/or material transfer agreements will also be required as applicable to outside researchers.