Effects of Variable Load Exercise on Aging Atrophy

NCT03690258 | Unknown DMC

• 1 other identifier: ARRS: Z7-9420
• Study Type: interventional
• Target: 30
• Locations: 1 country
• Sites: 2

Brief Summary

The primary aim of this research proposal is to examine whether this novel training program approach is capable to tackle excessive loss in muscle mass, function and contractile capacity with aging. Previous investigations have universally shown a dramatic loss in type II muscle fibers, while certain countermeasures in their follow-up studies were generally ineffective and limited to attenuate this phenomenon. Probably, they failed to meet recruitment threshold of larger motor units and subsequently innervate type II muscle fibers. Furthermore, previous investigations also failed to provide any data on specific blood markers that may provide additional insight into muscle fiber loss with aging. Muscle fibers type II play a crucial role in the human ability to produce as much as force as possible over a limited time-frame (e.g. 100-200 ms) to counteract unexpected perturbations during stair climbing for example and thus avoiding falls. Therefore, this data collection would be noteworthy in particular, especially for this population due to health-related outcomes and healthy aging process. Since age-related decline is accelerated already after short bouts of physical inactivity, with small recovery potential, any attempt to counteract age-related and disuse-related decline have high clinical significance. Based on the findings, data collected may aid in development of safety guidelines and protocols aimed at reducing health risks in this specific population. Importantly, in case the aforementioned hypotheses are confirmed, present findings may offer important information to the healthcare system, especially for reducing economic burden.

Conditions

Sarcopenia; Hypertension; Muscle Atrophy

Keywords

muscle function; muscle fibers; systolic blood pressure

Outcome Measures

Primary Outcomes (2)

• Continuous blood pressure monitoring via photopletismograpy (via Finometer) and non-invasive hemodynamics assessment

  Non-pharmacological intervention (exercise intervention); To address motor unit recruitment pattern with pre-post intervention data collection scheme.

  12-24 months

• Non invasive surface electromyography (HD EMG, in mV) during MVC (maximal voluntary contraction, Nm), Peak oxygen uptake assessment (VO2; ml kg min-1)

  Pulmonary ventilation and oxygen uptake at rest and during cycling. All data will be collected via a portable system (K5 RQ, Cosmed, Rome, Italy)

  12-24 months

Secondary Outcomes (1)

• Endothelial function (via non invasive flow mediated dilatation technique

  12-24 months

Study Arms (2)

Variable load exercise

EXPERIMENTAL

Variable load intervention (The nHANCE-squat ultimate - iso-inertial load, with power output in watts performed 3 x per week) will being performed to determine whether this training approach is an effective countermeasure to attenuate for rapid declines in muscle power, function, contractile capacity that typically originate from aging and muscle disuse. Since age-related decline is accelerated already after short bouts of physical inactivity, with small recovery potential, any attempt to counteract age-related and disuse-related decline have high clinical significance. Based on the findings, we could develop safety guidelines and protocols aimed at reducing health risks in seniors. Data available at: http://nhance.se/

Device: Variable load exercise

Variable load intervention

EXPERIMENTAL

This study is being conducted to determine whether this variable load (The nHANC dead lift - eccentric overload performed 3 x per week for 4-6 weeks) intervention is an effective countermeasure to modulate blood pressure in seniors. Since age-related incline in resting blood pressure (hypertension) is accelerated already after short bouts of physical inactivity, any attempt to counteract age-related and disuse-related decline have high clinical significance. In addition, we aim to examine endothelial function via non-invasive flow mediated dilatation (FMD) technique. Based on the findings, we could develop safety guidelines and protocols aimed at reducing health risks in this specific population. Importantly, in case present hypotheses are confirmed, this may offer important information to the healthcare system, especially for reducing economic burden.

Device: Variable load exercise

Interventions

Variable load exercise DEVICE

This study is being conducted to determine whether variable load training approach (nHANCE™ squat - more data available at http://nhance.se/) is an effective countermeasure to attenuate for rapid declines in muscle power, function, that typically originate from aging and muscle disuse. Since age-related decline is accelerated already after short bouts of physical inactivity, with small recovery potential, any attempt to counteract age-related and disuse-related decline have high clinical significance. Based on the findings, safety guidelines and protocols could be developed aimed at reducing health risks in seniors. Importantly, in case present hypotheses are confirmed, this may offer important information to the healthcare system.

Variable load exercise; Variable load intervention

Eligibility Criteria

• Age: 50 Years - 75 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Both genders will be included;
• signed informed consent and doctor's permission;
• Age \>50 years;
• BMI \<30 kg/m2,
• At least 30 minutes of daily moderate-to-vigorous physical activity during (including five days of monitoring prior to any data collection).

You may not qualify if:

• Severe cardiovascular diseases;
• hypertension prevalence (\>140/90 mm Hg).
• history of severe musculoskeletal and neurological disorders/injuries;
• history of severe neurological disorders;
• supplement or drug consumption that may interfere with training outcomes;
• alcohol consumption and smoking;
• use of walking aids;
• Data collection risks include potential transient discomfort from the venipuncture blood sampling and muscle soreness originating from experimental training protocols. The participants will get valuable information on how their muscles adapt following systematic training protocols.

Sponsors & Collaborators

• University Hospital of Split: lead
• Slovenian Research Agency: collaborator

Study Sites (2)

University of Primorska

Koper, 6000, Slovenia

NOT YET RECRUITING

ZRS Koper

Koper, 6000, Slovenia

RECRUITING

Related Publications (1)

• Zubac D, Obad A, Ivancev V, Valic Z. Acute flywheel exercise does not impair the brachial artery vasodilation in healthy men of varying aerobic fitness. Blood Press Monit. 2021 Jun 1;26(3):215-223. doi: 10.1097/MBP.0000000000000523.

  PMID: 33590994 DERIVED

Related Links

• Related Info

MeSH Terms

Conditions

Sarcopenia; Hypertension; Muscular Atrophy

Condition Hierarchy (Ancestors)

Neuromuscular Manifestations; Neurologic Manifestations; Nervous System Diseases; Atrophy; Pathological Conditions, Anatomical; Pathological Conditions, Signs and Symptoms; Signs and Symptoms; Vascular Diseases; Cardiovascular Diseases

Study Officials

• Rado Pisot, PhD

  Science and Research Center Koper, Institute for Kinesiology Research

  STUDY DIRECTOR

Central Study Contacts

Patricia Kompara, Msc

CONTACT

+386 5 663 77 08; patricia.kompara@zrs-kp.si

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: INVESTIGATOR
• Masking Details: Researches collecting data will be blinded of participant allocation.
• Purpose: PREVENTION
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: PhD

Model Details: Variable load exercise, non-pharmacological intervention

Study Record Dates

• First Submitted: September 25, 2018
• First Posted: October 1, 2018
• Study Start: July 5, 2019
• Primary Completion: March 30, 2020
• Study Completion: July 30, 2020
• Last Updated: September 26, 2019

Record last verified: 2019-09

Data Sharing

• IPD Sharing: Will not share

Locations

SL (2)