Does Tracheal Suction During Extubation in Intensive Care Unit Decrease Functional Residual Capacity

NCT03681626 | Completed

• 1 other identifier: 2015-A00846-43
• Study Type: interventional
• Target: 60
• Locations: 0 countries
• Sites: N/A

Brief Summary

Little is known about the procedure of extubation of patients admitted in Intensive Care Units (ICU). In particular, effects of tracheal suction during extubation have never been evaluated. Tracheal suction induces alveolar derecruitment in sedated patients under mechanical ventilation and is a major source of pain. The aim of this study was to evaluate the impact of tracheal suction during the extubation procedure of critically ill patients on the end-expiratory lung volume.

Conditions

Critically Ill; Extubation; Intensive Care Unit

Keywords

critically ill patient; extubation; tracheal suction; intensive care unit

Outcome Measures

Primary Outcomes (1)

• ΔEELI 15

  The primary endpoint was the end-expiratory lung impedance variation (ΔEELI) between immediately before extubation and 15 minutes after extubation (ΔEELI 15). It happened so 45 minutes after inclusion (30 minutes of extubation protocol and 15 minutes after extubation)

  15 minutes after extubation

Secondary Outcomes (10)

• ΔEELI H1

  60 minutes after extubation

• ΔEELI H2

  120 minutes after extubation

• Lowest oxygen saturation by pulse oximetry

  360 minutes after extubation

• Oxygen flow

  360 minutes after extubation

• arterial partial pressure of oxygen

  360 minutes after extubation

Study Arms (2)

tracheal suction

ACTIVE COMPARATOR

After a standardized protocol during the thirty minutes before extubation, extubation was performed with a standardized tracheal suction.

Procedure: tracheal suction

no tracheal suction

EXPERIMENTAL

After a standardized protocol during the thirty minutes before extubation, extubation was performed without tracheal suction.

Procedure: no tracheal suction

Interventions

no tracheal suction PROCEDURE

No tracheal suctioning during extubation

no tracheal suction

tracheal suction PROCEDURE

tracheal suctioning during extubation

tracheal suction

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• age of 18 years or more
• hospitalization in the surgical ICU (whatever the cause of hospitalization)
• under mechanical ventilation via a tracheal tube (oro or nasotracheal) for at least 24 hours
• satisfying general criteria for mechanical ventilation weaning (described by the French Language Resuscitation Society)
• having successfully completed a spontaneous breathing trial (among those described by the SRLF)
• physiotherapist available during the first hour after extubation

You may not qualify if:

• the presence of an electrical implantable medical device (pacemaker, automatic defibrillator, deep brain stimulation box)
• body mass index (BMI) \> 50
• pregnancy
• tracheal tube with subglottic suction channel
• technical impossibility of monitoring by electrical impedance tomography (chest plaster, undrained pneumothorax, ...).

Sponsors & Collaborators

• University Hospital, Rouen: lead

MeSH Terms

Conditions

Critical Illness

Condition Hierarchy (Ancestors)

Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Benoît VEBER, MD, PhD

  STUDY CHAIR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: SUPPORTIVE CARE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 6, 2018
• First Posted: September 24, 2018
• Study Start: October 27, 2015
• Primary Completion: August 31, 2016
• Study Completion: September 2, 2016
• Last Updated: September 24, 2018

Record last verified: 2018-09

Data Sharing

• IPD Sharing: Will not share