Motoric Cognitive Risk and Depression

NCT03679221 | Active Not Recruiting

• 1 other identifier: 2019-1501
• Study Type: observational
• Target: 30,000
• Locations: 1 country
• Sites: 1

Brief Summary

The overall objective of the proposal is to examine the association between depression and the newly reported "motoric cognitive risk" (MCR) syndrome, which is a pre-dementia syndrome combining subjective cognitive complaint (i.e.; memory complaint) with objective slow gait speed, in the Canadian population, with the baseline assessment of the Canadian Longitudinal Study on Aging (CLSA). The Canadian and global population are continuously aging. Moreover, the number of individuals affected by dementia is on the rise. One good predictor of dementia is Motoric Cognitive Risk (MCR) syndrome. MCR syndrome is a highly prevalent, newly defined syndrome that combines slow gait and subjective cognitive complaint. Depression is also highly prevalent in the older population and can affect both cognition and gait. Thus, an overlap between MCR and depression is possible. Yet few studies have examined the association between MCR and depression, thus emphasizing the importance of further investigating this association. This project encompasses determining the association of MCR syndrome with depression in the Canadian context as a step to better understand MCR syndrome in Canada.

Conditions

Depression; Geriatrics; Neurocognitive Disorders

Outcome Measures

Primary Outcomes (1)

• Subjective cognitive complaint

  elicited from the 60-minute interview telephone questionnaire item Chronic Conditions Tracking (CTT\_19 CCT\_MEMPB\_TRM) done in CLSA study

  1 hour

Secondary Outcomes (1)

• Slow gait speed

  1 day

Study Arms (4)

Group 45-54 years old

divided in two subgroups: individuals with and without cardio-vascular risk factors and diseases

Other: Data collection

Group 54-64 years old

divided in two subgroups: individuals with and without cardio-vascular risk factors and diseases

Other: Data collection

Group 65-74 years old

divided in two subgroups: individuals with and without cardio-vascular risk factors and diseases

Other: Data collection

Group 75-85 years old

divided in two subgroups: individuals with and without cardio-vascular risk factors and diseases

Other: Data collection

Interventions

Data collection OTHER

telephone interview questionnaire, in-home face-to-face interview, and data from the Collection Site

Group 45-54 years old; Group 54-64 years old; Group 65-74 years old; Group 75-85 years old

Eligibility Criteria

• Age: 45 Years - 85 Years
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Individuals eligible for this study will be the participants of the CLSA

You may qualify if:

• be participant of the comprehensive CLSA

You may not qualify if:

• dementia,
• mobility disability,
• no information about cognitive complaint,
• no measure of walking speed

Sponsors & Collaborators

• Jewish General Hospital: lead

Study Sites (1)

Jewish General Hospital

Montreal, Quebec, H3T 1E2, Canada

Location

MeSH Terms

Conditions

Depression; Neurocognitive Disorders

Interventions

Data Collection

Condition Hierarchy (Ancestors)

Behavioral Symptoms; Behavior; Mental Disorders

Intervention Hierarchy (Ancestors)

Epidemiologic Methods; Investigative Techniques; Health Care Evaluation Mechanisms; Quality of Health Care; Health Care Quality, Access, and Evaluation; Public Health; Environment and Public Health

Study Officials

• Olivier Beauchet, MD

  Jewish General Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor of Geriatrics

Study Record Dates

• First Submitted: September 18, 2018
• First Posted: September 20, 2018
• Study Start: July 24, 2019
• Primary Completion: October 31, 2024
• Study Completion: December 1, 2025
• Last Updated: February 23, 2024

Record last verified: 2024-02

Locations

CA (1)