Diffusion Tensor Imaging of Myelopathy

NCT03665935 | Unknown

• 1 other identifier: DTI in myelopathy
• Study Type: observational
• Target: 70
• Locations: 0 countries
• Sites: N/A

Brief Summary

Myelopathy describes any neurologic deficit related to the spinal cord. Myelopathy is caused by various pathological states of the human spinal cord, including tumors, inflammatory lesions, spinal cord compression and degenerative myelopathy. Clinically, the diagnosis of myelopathy depends on localization of the neurologic finding to the spinal cord, rather than the brain or peripheral nervous system and then to a particular segment of the spinal cord. Magnetic resonance imaging (MRI) plays an essential role in the diagnosis and follow-up of the lesions of the spinal cord using conventional MRI T1- and T2-weighted sequences. Sometimes a studied spinal cord may appear normal on conventional MRI even though patients have symptoms of myelopathy causing a discrepancy between MRI findings and clinical findings. Diffusion tensor imaging (DTI) is an advanced non-invasive MR imaging technique which assesses the microstructural integrity of nerve fiber tracts.

Conditions

Myelopathy

Outcome Measures

Primary Outcomes (1)

• To determine the usefulness of diffusion tensor imaging (DTI) and fiber tracking in evaluation of myelopathy.

  assessing white matter tract affection in various disease and damage involving the spinal cord using the DTI indices, quantitatively using ADC and FA measurement and qualitatively using tractogram to assess spinal cord lesions and compare the results to conventional MRI sequences

  one year

Eligibility Criteria

• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

A 70 patient with myelopathy will be included in the study. the study will be performed at radiology department in Assiut University Hospital. Using Magnetic Resonance imaging device 1.5 tesla scanners. First imaging the spine by acquiring the conventional sequences and second the diffusion tensor sequence.

You may qualify if:

• Clinical symptoms of myelopathy

You may not qualify if:

• Previous spine surgery
• Spine radiation therapy
• Cerebral palsy
• Contraindication to MR imaging.

Sponsors & Collaborators

• Assiut University: lead

Related Publications (1)

• Kamble RB, Venkataramana NK, Naik AL, Rao SV. Diffusion tensor imaging in spinal cord injury. Indian J Radiol Imaging. 2011 Jul;21(3):221-4. doi: 10.4103/0971-3026.85372.

  PMID: 22013299 BACKGROUND

MeSH Terms

Conditions

Spinal Cord Diseases

Condition Hierarchy (Ancestors)

Central Nervous System Diseases; Nervous System Diseases

Study Officials

• Mona Gouda, ass lecturer

  Assiut University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Abd El-Karem Hasan, professor

CONTACT

01224652032; abdelkarem_5555@yahoo.com

Mohamed Zidan, A.professor

CONTACT

01001121365; mzidan74@yahoo.com

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: principle investigator

Study Record Dates

• First Submitted: September 6, 2018
• First Posted: September 11, 2018
• Study Start: September 1, 2018
• Primary Completion: September 1, 2019
• Study Completion: December 1, 2019
• Last Updated: September 11, 2018

Record last verified: 2018-09