Stroke-like Migraine Attacks After Radiation Treatment (SMART) Syndrome Language Intervention

NCT03662295 | Completed

• 1 other identifier: SMART
• Study Type: observational
• Target: 1
• Locations: 1 country
• Sites: 1

Brief Summary

Stroke-like migraine attacks after radiation therapy-also known as SMART syndrome-constitute a rare condition typically characterized by headache, seizures, vision abnormalities, hemiparesis, and aphasia. The condition usually resolves within a few days or weeks of onset with no residual impairments. However, resolution in some cases extends over a period of months rather than weeks and may be incomplete. The purpose of this case report is to provide an in-depth description of the progression of changes in cognitive and language functioning for a person exhibiting SMART syndrome characterized by slow recovery.

Conditions

Migraine Disorders; Aphasia

Keywords

Cognitive Impairment

Outcome Measures

Primary Outcomes (1)

• Standardized assessment

  Aphasia Quotient of the Western Aphasia Battery - Revised

  Change from baseline at 6 months

Secondary Outcomes (2)

• Spoken picture description

  Change from baseline at 6 weeks, 10 weeks, 14 weeks, 20 weeks, and 26 weeks

• Written picture description

  Change from baseline at 6 weeks, 10 weeks, 14 weeks, 20 weeks, and 26 weeks

Interventions

Language treatment BEHAVIORAL

Individual speech-language therapy sessions totaling 1.5 to 2.5 hours five days per week. Intervention activities include performing oral and written confrontation and responsive naming, writing single words to dictation, reading single words and sentences aloud, and generating written and spoken picture descriptions.

Eligibility Criteria

• Age: 19 Years - 65 Years
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

One adult with SMART syndrome will participate in this study. The person will have cognitive and language deficits typical of those exhibited by people with SMART syndrome. Given the rarity of the disorder, only one participant is anticipated.

You may qualify if:

• exhibit cognitive and language deficits secondary to SMART syndrome
• be a former or current client of Quality Living, Inc., Omaha, Nebraska
• be a native speaker of English

Sponsors & Collaborators

• Quality Living, Inc.: lead

Study Sites (1)

Quality Living, Inc.

Omaha, Nebraska, 68104, United States

Location

MeSH Terms

Conditions

Migraine Disorders; Aphasia; Cognitive Dysfunction

Condition Hierarchy (Ancestors)

Headache Disorders, Primary; Headache Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Speech Disorders; Language Disorders; Communication Disorders; Neurobehavioral Manifestations; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Cognition Disorders; Neurocognitive Disorders; Mental Disorders

Study Officials

• Karen Hux, Ph.D.

  Quality Living, Inc., Omaha, Nebraska

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Director of Research

Study Record Dates

• First Submitted: September 3, 2018
• First Posted: September 7, 2018
• Study Start: September 3, 2018
• Primary Completion: November 13, 2019
• Study Completion: November 13, 2019
• Last Updated: March 10, 2021

Record last verified: 2021-03

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)