Fungal Infections in Patients With Hematological Malignancies

NCT03650439 | Unknown

• 1 other identifier: fungal infections
• Study Type: observational
• Target: 50
• Locations: 0 countries
• Sites: N/A

Brief Summary

\* Report the prevalence of fungal infections among patients with hematological malignancies in South Egypt Cancer Institute. \* Detect the most endemic fungal pathogen isolated from patients with hematological malignancies in South Egypt Cancer Institute. \*Antifungal susceptibility testing which guide the optimal approach to treat fungal infections. \* detection of resistant gene expression by real time PCR. \* Fungal genome sequencing analysis to determine the genetic back ground upon which mutation and resistance occur.

Conditions

Fungal Infection

Outcome Measures

Primary Outcomes (1)

• identification of endemic fungal pathogen in patients with hematological malignancies south Egypt cancer institute.

  Detect the most endemic fungal pathogen isolated from clinical sampels of patients with hematological malignancies in South Egypt Cancer Institute.

  one year study

Interventions

culture on Sabouraud's Dextrose Agar (SDA) DIAGNOSTIC_TEST

• Clinical samples will be cultured onto Sabouraud's Dextrose Agar (SDA) plates supplemented with chloramphenicol. the culture was incubated at 25 C° and at 37° C (for yeasts and moulds isolation )

Also known as: E test

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

study design that is intended to include adult patients with fungal infections as acomplication in hematologicayl malignant patients who would be recruited from South Egypt Cancer Institute outpatient clinic or inpatient ward

You may qualify if:

• Immunocompromised adult patient with hematological malignancy , risky to fungal infection as
• patients receiving cytotoxic or immunosuppressive therapy. Patients with prolonged and deep neutropenia.
• patients exposed to prolonged use of antibiotic , prolonged Foley catheter drainage peripheral I.V catheters, corticosteroid use
• patients have presentations of fungal infection such as pulmonary infections ( pneumonia , sinusitis). and disseminated infection manifested commonly as skin lesions or soft tissue involvement .

You may not qualify if:

• Non hematologicaly malignant patients .
• Any contraindication regarding procedure as:
• Local infection or distorted anatomy at the potential puncture site (eg, from previous surgical interventions,congenital or acquired malformations, or burns)
• Severe peripheral vascular disease of the limb involved

Sponsors & Collaborators

• Assiut University: lead

MeSH Terms

Conditions

Mycoses

Condition Hierarchy (Ancestors)

Bacterial Infections and Mycoses; Infections

Central Study Contacts

fatma adel

CONTACT

00201065703188; fatmahaseib@gmail.com

Khalid Mohammed

CONTACT

00201118508060; khaledhassanein70@aun.edu.eg

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Doctor

Study Record Dates

• First Submitted: August 26, 2018
• First Posted: August 28, 2018
• Study Start: October 1, 2018
• Primary Completion: September 30, 2019
• Study Completion: October 31, 2019
• Last Updated: August 28, 2018

Record last verified: 2018-08