Systemic Fungal Infections in ICU Patients

NCT03292224 | Unknown

• 1 other identifier: SFI in ICU Patients
• Study Type: observational
• Target: 100
• Locations: 0 countries
• Sites: N/A

Brief Summary

This study aims to :

1. 1.Diagnosis of Systemic fungal infections in ICU patients.
2. 2.Detection the most common fungal species in ICU.
3. 3.Detection of in vitro antifungal sensitivity pattern

Conditions

Fungal Infection

Outcome Measures

Primary Outcomes (1)

• Positive cultures of collected specimens from patients in ICU with suspected SFI.

  samples (blood ,urine and sputum) will be taken under complete aseptic precautions in sterile containers and carried immediately for culturing on sabouraud dextrose agar .Positive cultures help in early diagnosis of systemic fungal infections

  2weeks

Interventions

- Microscopic examination and culture of collected specimens DIAGNOSTIC_TEST

1. Unstained wet mount with 10%-20% KOH. 2. Wet mounts stained with: * Lactophenol cotton blue. * India ink * Gram stain Culturing on Sabouraud´s dextrose agar .

Also known as: • Complete blood picture and Chest radiography.

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

This study will include patients who will be admitted to intensive care unit in Assiut University Hospital regardless to age and sex.

You may qualify if:

• Suppressed immunity such as: (patients with malignancy under chemotherapy, prolonged use of corticosteroids.………etc)
• Manifestations of chest infection e.g.cough, Haemoptysis, dyspnea and chest discomfort.
• Persistent fever resistant to antibiotic therapy.
• Urinary manifestations resistant to antibiotic therapy.

You may not qualify if:

• Patients who received antifungal therapy within 3 days prior to sample collection.
• Patients refused to participate in the study.

Sponsors & Collaborators

• Assiut University: lead

Related Publications (4)

• Jensen J, Guinea J, Torres-Narbona M, Munoz P, Pelaez T, Bouza E. Post-surgical invasive aspergillosis: an uncommon and under-appreciated entity. J Infect. 2010 Feb;60(2):162-7. doi: 10.1016/j.jinf.2009.11.005. Epub 2009 Nov 20.

  PMID: 19932132 BACKGROUND

• Leleu G, Aegerter P, Guidet B; College des Utilisateurs de Base de Donnees en Reanimation. Systemic candidiasis in intensive care units: a multicenter, matched-cohort study. J Crit Care. 2002 Sep;17(3):168-75. doi: 10.1053/jcrc.2002.35815.

  PMID: 12297992 BACKGROUND

• Pappas PG, Kauffman CA, Andes DR, Clancy CJ, Marr KA, Ostrosky-Zeichner L, Reboli AC, Schuster MG, Vazquez JA, Walsh TJ, Zaoutis TE, Sobel JD. Clinical Practice Guideline for the Management of Candidiasis: 2016 Update by the Infectious Diseases Society of America. Clin Infect Dis. 2016 Feb 15;62(4):e1-50. doi: 10.1093/cid/civ933. Epub 2015 Dec 16.

  PMID: 26679628 BACKGROUND

• O'Keefe SJ, Sender PM, Clark CG, James WP. Proceedings: The dynamics of protein metabolism following operative trauma. Clin Sci Mol Med. 1974 Sep;47(3):15P. doi: 10.1042/cs047015pa. No abstract available.

  PMID: 4419464 BACKGROUND

MeSH Terms

Conditions

Mycoses

Interventions

Microscopy; Diagnostic Imaging

Condition Hierarchy (Ancestors)

Bacterial Infections and Mycoses; Infections

Intervention Hierarchy (Ancestors)

Diagnostic Techniques and Procedures; Diagnosis; Investigative Techniques

Central Study Contacts

Mohamed zakaria, Dr

CONTACT

01001983060; m-z-abokrisha@yahoo.com

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Target Duration: 2 Weeks
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Resident Doctor

Study Record Dates

• First Submitted: August 29, 2017
• First Posted: September 25, 2017
• Study Start: September 28, 2017
• Primary Completion: September 1, 2018
• Study Completion: October 15, 2019
• Last Updated: September 25, 2017

Record last verified: 2017-09