Effect of Location of Tetanic Stimuli on Photoplethysmogram
1 other identifier
interventional
12
1 country
1
Brief Summary
The effect of the location of tetanic stimulus on photoplethysmography signals will be studies in patients under general anesthesia.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable
Started Sep 2018
Shorter than P25 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
August 24, 2018
CompletedFirst Posted
Study publicly available on registry
August 27, 2018
CompletedStudy Start
First participant enrolled
September 1, 2018
CompletedPrimary Completion
Last participant's last visit for primary outcome
November 30, 2018
CompletedStudy Completion
Last participant's last visit for all outcomes
November 30, 2018
CompletedResults Posted
Study results publicly available
April 30, 2020
CompletedMay 22, 2020
May 1, 2020
3 months
August 24, 2018
March 7, 2020
May 9, 2020
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Photoplethysmography (PPG)
Change in the PPG signal in response to tetanic stimulus. A tetanic stimulus will cause vasoconstriction which can be recorded as a decrease in PPG AC/DC. The outcome measure is the maximum decrease in AC/DC from baseline. Maximum decrease happens typically in 30-60 seconds after the stimulus. Thus, data was collected immediately before (baseline) and for 2 min after the stimulus. After the stimulus AC/DC values return to baseline in a few minutes. Baseline AC/DC measures a relative state of blood vessel tone. In anesthetized patients the AC/DC values can range from close to 0 to above 10. The higher the value, the more vasodilated the subject is.
1-2 minutes
Study Arms (1)
intervention
EXPERIMENTALall participants receive the same intervention
Interventions
5 second 100 Hz 70 mA tetanic stimulus will be applied to three different locations in a random order
Eligibility Criteria
You may qualify if:
- Surgical patients general anesthesia able to consent in english
You may not qualify if:
- regional anesthesia unable to consent in english under 18 yrs of age
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
University of California San Francisco
San Francisco, California, 94122, United States
Related Publications (1)
Talke P, Talke I. Effect of the Location of Tetanic Stimulation on Autonomic Responses: A Randomized Cross-Over Pilot Study. J Pain Res. 2024 Jan 9;17:209-217. doi: 10.2147/JPR.S443058. eCollection 2024.
PMID: 38223663DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Results Point of Contact
- Title
- Pekka Talke
- Organization
- UCalifornia San Francisco
Publication Agreements
- PI is Sponsor Employee
- No
- Restrictive Agreement
- No
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NA
- Masking
- NONE
- Purpose
- DIAGNOSTIC
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- MD
Study Record Dates
First Submitted
August 24, 2018
First Posted
August 27, 2018
Study Start
September 1, 2018
Primary Completion
November 30, 2018
Study Completion
November 30, 2018
Last Updated
May 22, 2020
Results First Posted
April 30, 2020
Record last verified: 2020-05
Data Sharing
- IPD Sharing
- Will not share