Assessment of Response to the Conventional Periodontal Treatment Based on the Blood Group Phenotypes.

NCT03644901 | Completed DMC

• 1 other identifier: UDDS-Perio-03-2018
• Study Type: observational
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this study is to find out if one blood group phenotype is more responsive than the others to the nonsurgical periodontal treatment.

Conditions

Chronic Periodontitis

Outcome Measures

Primary Outcomes (1)

• Change in relative attachment level.

  the relative attachment level measures the length form the base of the periodontal pocket to a stent

  measures will be taken at baseline and after two months from treatment.

Secondary Outcomes (3)

• Change in periodontal probing depth.

  measures will be taken at baseline and after two months from treatment.

• Change in gingival index

  index will be taken at baseline and after two months from treatment.

• Change in plaque Index

  index will be taken at baseline and after two months from treatment.

Study Arms (4)

Patients whose blood type is A

Applying nonsurgical periodontal treatment (scaling and root planning).

Procedure: nonsurgical periodontal treatment

Patients whose blood type is B

Applying nonsurgical periodontal treatment (scaling and root planning).

Procedure: nonsurgical periodontal treatment

Patients whose blood type is AB

Applying nonsurgical periodontal treatment (scaling and root planning).

Procedure: nonsurgical periodontal treatment

Patients whose blood type is O

Applying nonsurgical periodontal treatment (scaling and root planning).

Procedure: nonsurgical periodontal treatment

Interventions

nonsurgical periodontal treatment PROCEDURE

patients will undergo nonsurgical periodontal treatment to reduce the relative attachment level and improve the probing depth. An initial session will be conducted to remove supra gingival plaque and calculus. another appointment is set to perform full moth scalling and root planing.

Also known as: Conventional periodontal treatment, scalling and root planing

Patients whose blood type is A; Patients whose blood type is AB; Patients whose blood type is B; Patients whose blood type is O

Eligibility Criteria

• Age: 20 Years - 60 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)
• Sampling Method: Probability Sample

Study Population

Patients suffering from chronic periodontitis

You may qualify if:

• systematically healthy.
• have at least 20 teeth excluding the third molars.
• had not received any periodontal treatment or antibiotic therapy for dental or medical reason 6 month prior to the study.
• diagnosed with generalized chronic periodontitis (\>30% of the sites have probing depth ≥4), and a minimum of six teeth with probing depth of 5-6 mm.

You may not qualify if:

• smokers and alcoholics.
• pregnancy.
• history of a systematic disease such as diabetes, leukemia, epilepsy.
• participants who are unable to perform routine oral hygiene.
• use of orthodontic appliances.
• participants who are unable to perform routine oral hygiene.

Sponsors & Collaborators

• Damascus University: lead

Study Sites (1)

Department of Periodontics

Damascus, DM20AM18, Syria

Location

Related Publications (5)

• Pai GP, Dayakar MM, Shaila M, Dayakar A. Correlation between "ABO" blood group phenotypes and periodontal disease: Prevalence in south Kanara district, Karnataka state, India. J Indian Soc Periodontol. 2012 Oct;16(4):519-23. doi: 10.4103/0972-124X.106892.

  PMID: 23493096 BACKGROUND

• Demir T, Tezel A, Orbak R, Eltas A, Kara C, Kavrut F. The Effect of ABO Blood Types on Periodontal Status. Eur J Dent. 2007 Jul;1(3):139-43.

  PMID: 19212557 BACKGROUND

• Gautam A, Mittal N, Singh TB, Srivastava R, Verma PK. Correlation of ABO Blood Group Phenotype and Rhesus Factor with Periodontal Disease: An Observational Study. Contemp Clin Dent. 2017 Apr-Jun;8(2):253-258. doi: 10.4103/ccd.ccd_307_17.

  PMID: 28839412 BACKGROUND

• Wang W, Liu L, Wang Z, Wei M, He Q, Ling T, Cao Z, Zhang Y, Wang Q, Shi M. Impact of ABO blood group on the prognosis of patients undergoing surgery for esophageal cancer. BMC Surg. 2015 Sep 29;15:106. doi: 10.1186/s12893-015-0094-1.

  PMID: 26420728 BACKGROUND

• Yu Q, Wang L, Zhang S, Feng T, Li L, Chen B, Chen M. The role of ABO blood groups in Crohn's disease and in monitoring response to infliximab treatment. Blood Transfus. 2016 Sep;14(5):460-4. doi: 10.2450/2016.0199-15. Epub 2016 Feb 24.

  PMID: 27136434 BACKGROUND

MeSH Terms

Conditions

Chronic Periodontitis

Interventions

Root Planing

Condition Hierarchy (Ancestors)

Periodontitis; Periodontal Diseases; Mouth Diseases; Stomatognathic Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Dental Scaling; Dental Prophylaxis; Periodontics; Dentistry; Subgingival Curettage; Preventive Dentistry

Study Officials

• Mohammad Ammar Kouky, DDS MSc

  PhD Student in Periododontics, University of Damascus Dental School, Damascus

  PRINCIPAL INVESTIGATOR

• Mohammad Monzer Alsabbagh, DDS MSc PhD

  Associate Professor of Periodontics, University of Damascus Dental School, Damascus, Syria

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 2, 2018
• First Posted: August 23, 2018
• Study Start: January 15, 2018
• Primary Completion: October 1, 2018
• Study Completion: March 10, 2019
• Last Updated: March 13, 2019

Record last verified: 2019-03

Data Sharing

• IPD Sharing: Will not share

Locations

SY (1)