Relationship Between Chronic Periodontitis and Vitamin D and Calcium in Men

NCT02127346 | Completed DMC

• 1 other identifier: UDDS-Perio-04-2014
• Study Type: observational
• Target: 200
• Locations: 1 country
• Sites: 1

Brief Summary

Objective: The objective was to evaluate whether serum vitamin D and calcium concentrations are associated with chronic periodontitis in Syrian men Methods: This study designed as "Matched Case-Control Study".200 males will be enrolled in this study and will be divided into two groups. First group consist of 100 patients suffering from chronic periodontitis and no systemic diseases. Second group consist of 100 healthy volunteers. Serum vitamin D and calcium concentrations will be tested. Periodontal indexes include probing depth (PD), clinical attachment level (CAL), and bleeding on probing (BOP) will be taken. Data will be collected and analyzed.

Conditions

Chronic Periodontitis

Keywords

Chronic Periodontitis; Vitamin D concentration; Calcium concentration

Outcome Measures

Primary Outcomes (2)

• Serum Vitamin D concentration

  One time assessment, within 24 hours before delivering any treatment

• Serum Calcium concentration

  One time assessment, within 24 hours before delivering any treatment

Secondary Outcomes (3)

• Pocket Depth

  One time assessment once sample recruitment has completed and within 24 hours before delivering any treatment.

• Bleeding on Probing

  One time assessment once sample recruitment has completed and within 24 hours before delivering any treatment.

• Clinical Attachment Loss (CAL)

  One time assessment once sample recruitment has completed and within 24 hours before delivering any treatment.

Study Arms (2)

Chronic Periodontitis

1. Male patients 2. Patients are suffering from chronic periodontitis 3. Patients do not have any systemic diseases 4. Subjects should have 20 teeth at least 5. Age: 30 years or greater

Healthy Volunteers

1. Males 2. Healthy with no systemic diseases or periodontitis 3. 30 years old at least 4. 20 teeth are present at least

Eligibility Criteria

• Age: 30 Years - 50 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Patients who are referred to the Periodontics Department at University of Damascus Dental School (Damascus, Syria) will be recruited in this research project. Healthy volunteers will be invited to participate in this research.

You may qualify if:

• Male patients
• Patients are suffering from chronic periodontitis
• Patients do no have systemic diseases
• Patients should have 20 teeth at least
• year old at least
• Male individuals
• With no systemic diseases or periodontitis
• year old at least
• teeth at least for each participant

Sponsors & Collaborators

• Damascus University: lead

Study Sites (1)

Department of Periodontics, University of Damascus Dental School

Damascus, Rif-dimashq Governorate, DM20AM18, Syria

Location

Related Publications (7)

• Chapuy MC, Meunier PJ. [Calcium and vitamin D3, a prevention of femoral neck fractures in elderly women]. Presse Med. 1993 Apr 10;22(13):615-6. No abstract available. French.

  PMID: 8390053 BACKGROUND

• Crowle AJ, Ross EJ, May MH. Inhibition by 1,25(OH)2-vitamin D3 of the multiplication of virulent tubercle bacilli in cultured human macrophages. Infect Immun. 1987 Dec;55(12):2945-50. doi: 10.1128/iai.55.12.2945-2950.1987.

  PMID: 3119492 BACKGROUND

• Dennison DK, Van Dyke TE. The acute inflammatory response and the role of phagocytic cells in periodontal health and disease. Periodontol 2000. 1997 Jun;14:54-78. doi: 10.1111/j.1600-0757.1997.tb00192.x. No abstract available.

  PMID: 9567966 BACKGROUND

• Jeffcoat M. The association between osteoporosis and oral bone loss. J Periodontol. 2005 Nov;76(11 Suppl):2125-32. doi: 10.1902/jop.2005.76.11-S.2125.

  PMID: 16277585 BACKGROUND

• Kinane DF. Causation and pathogenesis of periodontal disease. Periodontol 2000. 2001;25:8-20. doi: 10.1034/j.1600-0757.2001.22250102.x. No abstract available.

  PMID: 11155179 BACKGROUND

• Liu H, Komai-Koma M, Xu D, Liew FY. Toll-like receptor 2 signaling modulates the functions of CD4+ CD25+ regulatory T cells. Proc Natl Acad Sci U S A. 2006 May 2;103(18):7048-53. doi: 10.1073/pnas.0601554103. Epub 2006 Apr 21.

  PMID: 16632602 BACKGROUND

• Ramanathan B, Davis EG, Ross CR, Blecha F. Cathelicidins: microbicidal activity, mechanisms of action, and roles in innate immunity. Microbes Infect. 2002 Mar;4(3):361-72. doi: 10.1016/s1286-4579(02)01549-6.

  PMID: 11909747 BACKGROUND

MeSH Terms

Conditions

Chronic Periodontitis

Condition Hierarchy (Ancestors)

Periodontitis; Periodontal Diseases; Mouth Diseases; Stomatognathic Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Mohammad Alharissi, DDS MSc

  PhD student, Department of Periodontics, University of Damascus Dental School, Damascus

  PRINCIPAL INVESTIGATOR

• Suleiman Dayoub, DDS MSc PhD

  Associate Professor of Periodontics, Department of Periodontics, University of Damascus Dental School, Damascus

  STUDY CHAIR

• Rowaida Saymeh, DDS MSc PhD

  Professor of Periodontics, Department of Periodontics, University of Damascus Dental School, Damascus

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 25, 2014
• First Posted: April 30, 2014
• Study Start: May 1, 2014
• Primary Completion: August 1, 2015
• Study Completion: October 1, 2015
• Last Updated: October 5, 2015

Record last verified: 2015-10

Locations

SY (1)