Preoperative Pain and POCD in Elderly Patients
Preoperative Chronic Pain Increases the Risk of Early Postoperative Cognitive Dysfunction in Elderly Patients Undergoing Hip Joint Replacement Surgery: a Prospective Observational Cohort Study
1 other identifier
observational
100
1 country
2
Brief Summary
The purpose of this study is to investigate whether preoperative pain is the risk factor of POCD in elder patients.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started Jan 2018
Typical duration for all trials
2 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
December 26, 2017
CompletedFirst Posted
Study publicly available on registry
January 8, 2018
CompletedStudy Start
First participant enrolled
January 10, 2018
CompletedPrimary Completion
Last participant's last visit for primary outcome
March 31, 2020
CompletedStudy Completion
Last participant's last visit for all outcomes
March 31, 2020
CompletedMarch 10, 2020
March 1, 2020
2.2 years
December 26, 2017
March 8, 2020
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
POCD incidence 7 days (or before leaving hospital) after surgery
POCD incidence 7 days (or before leaving hospital) after surgery
7 days (or before leaving hospital)
Secondary Outcomes (1)
POCD incidence 2 months after surgery
2 months after surgery
Eligibility Criteria
Elderly patients underwent elective low limb surgery(hemiarthroplasty or total hip arthroplasty); Chronic pain duration \>3 months.
You may qualify if:
- Elder than 65 years old
- Speak Chinese Mandarin
- Those who will undergo major low limb surgery like hemiarthroplasty or total hip arthroplasty with general anesthesia.
- Signed the inform consent
- American Society of Anesthesiologists classification I to II
You may not qualify if:
- Existing cerebral disease, or have a history of neurological and psychiatric disease including Alzheimer Disease, stroke, epilepsy and psychosis
- Existing cognitive impairment as evidenced by Mini-Mental State Examination scores below 24
- Severe hearing or visual impairment
- Unwillingness to comply with the protocol or procedures
- Cannot communicate with Chinese Mandarin
- Serious pulmonary, heart , liver or renal insufficiency patients
- Had anesthesia or surgery within the past 30 days
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- RenJi Hospitallead
Study Sites (2)
Reni Hospital, Shanghai Jiao Tong University, School of Medicine
Shanghai, Shanghai Municipality, 200127, China
Shanghai Ren ji Hospital
Shanghai, Shanghai Municipality, 200127, China
Related Publications (1)
Huai X, Jiao Y, Gu X, Zhu H, Chen L, Fan Y, Yu W, Su D, Xie H. Preoperative Chronic Pain as a Risk Factor for Early Postoperative Cognitive Dysfunction in Elderly Patients Undergoing Hip Joint Replacement Surgery: A Prospective Observational Cohort Study. Front Neurosci. 2021 Dec 17;15:747362. doi: 10.3389/fnins.2021.747362. eCollection 2021.
PMID: 34975369DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- STUDY CHAIR
Weifeng Yu, MD
Anesthesiology Department Renji Hospital, Shanghai
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Dr.
Study Record Dates
First Submitted
December 26, 2017
First Posted
January 8, 2018
Study Start
January 10, 2018
Primary Completion
March 31, 2020
Study Completion
March 31, 2020
Last Updated
March 10, 2020
Record last verified: 2020-03