Prevalence of Deficiency of Vitamin D in Critically Ill Patients

NCT03639584 | Completed

• 1 other identifier: 201805087RINB
• Study Type: observational
• Target: 662
• Locations: 1 country
• Sites: 1

Brief Summary

Vitamin D has been shown to related to clinical outcomes in critically ill patients. The object of this study is to investigate the prevalence of Vitamin D deficiency in critically ill patients with various length of ICU stay .

Conditions

Vitamin D Deficiency; Critical Illness

Keywords

Vitamin D Deficiency; Critical Illness

Outcome Measures

Primary Outcomes (1)

• The prevalence of Vitamin D deficiency

  Investigate the prevalence of vitamin D deficiency among groups

  1 day at enrollment

Secondary Outcomes (5)

• Difference of mortality on 28th and 90th day in group 2

  90 days

• Difference of mortality on 28th and 90th day in group 3, 4, and 5

  90 days

• Serial changes of serum vitamin D levels in group 2

  28 days

• Difference of 28-day ventialtor-free days

  28 days

• Difference of 28-day ICU-free days

  28 days

Study Arms (5)

Group 1

Patients admitted to ICU less than 48 hours and the anticipated stay is less than 5 days. Take blood sample on the day of enrollment.

Group 2

Patients admitted to ICU less than 48 hours and the anticipated stay is longer than 5 days. Take blood sample on the day of enrollment, 7th, 14th, 21st, and 28th. Stop blood sample once exit.

Group 3

Patients admitted to ICU 3\~7 days. Take blood sample on the day of enrollment.

Group 4

Patients admitted to ICU 8\~14 days. Take blood sample on the day of enrollment.

Group 5

Patients admitted to ICU 15\~28 days. Take blood sample on the day of enrollment.

Eligibility Criteria

• Age: 20 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

This is a multi-center, cross-sectional study involving four medical center in Taipei, Taiwan, which are National Taiwan University Hospital (NTUH), Far Eastern Memorial Hospital (FEMH), MacKay Memorial Hospital (MMH), and Taipei Medical University Hospital (TMUH). The target population is all the ICU patients, divided into four groups according to the length of ICU stay. The serum level of vit D, ICU event such as infection, ventilator dependency is to be recorded.

You may qualify if:

• All ICU patients

You may not qualify if:

• , Less than 20 years 2, BMI \< 18 kg/m\^2 3, Had large dose vit D within previous four weeks (over 3000 IU per day) 4, ICU admission within previous three months 5, Have disease affecting vit D level, calcium metabolism, bone metabolism such as parathyroid disease, Rickets, liver cirrhosis child C 6, Communication difficulty

Sponsors & Collaborators

• National Taiwan University Hospital: lead

Study Sites (1)

National Taiwan University Hospital

Taipei, 100, Taiwan

Location

Related Publications (1)

• Kuo YT, Kuo LK, Chen CW, Yuan KC, Fu CH, Chiu CT, Yeh YC, Liu JH, Shih MC. Score-based prediction model for severe vitamin D deficiency in patients with critical illness: development and validation. Crit Care. 2022 Dec 21;26(1):394. doi: 10.1186/s13054-022-04274-9.

  PMID: 36544226 DERIVED

Biospecimen

Retention: SAMPLES WITHOUT DNA

blood sample

MeSH Terms

Conditions

Vitamin D Deficiency; Critical Illness

Condition Hierarchy (Ancestors)

Avitaminosis; Deficiency Diseases; Malnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Chung-Wei Chen, MD

  Far Eastern Memorial Hospital

  PRINCIPAL INVESTIGATOR

• Li-Kuo Kuo, MD

  Mackay Memorial Hospital

  PRINCIPAL INVESTIGATOR

• Kuo-Ching Yuan, MD

  Taipei Medical University Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 14, 2018
• First Posted: August 21, 2018
• Study Start: August 23, 2018
• Primary Completion: July 30, 2020
• Study Completion: November 30, 2020
• Last Updated: April 22, 2021

Record last verified: 2021-04

Locations

TW (1)