NCT03631498|Completed
Apoptotic Changes in Gingiva Caused by Smoking
Apoptosis and Tissue Destruction in Gingival Tissues of Smoker and Non-smoker Periodontitis Patients
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Apoptosis and Tissue Destruction in Gingival Tissues of Smoker and Non-smoker Periodontitis Patients
Sponsor study identifier
observational
60
1 country
1
Study Start
January 10, 2017
Actual (reported)Primary Completion
January 10, 2018
Actual (reported)Study Completion
April 10, 2018
Actual (reported)Smoking is a major environmental risk factor associated with common forms of human chronic periodontitis. The aim of the present study was to evaluate apoptotic tissue alterations and tissue destruction in smoker and non-smoker chronic periodontitis patients and healthy individuals. The investigators of the study suggest that smoking decrease tissue quality and increase inflammation level in gingival tissues in both healthy individuals and periodontitis patients. One possible mechanism for this is suggested to be increased apoptosis.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
April 10, 2018
Actual (reported)Click on a node to explore related trials.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
January 10, 2017
Actual (reported)January 10, 2018
Actual (reported)April 10, 2018
Actual (reported)August 13, 2018
Actual (reported)August 15, 2018
Actual (reported)Fibroblast and total inflammatory cell counts
Fibroblast and total inflammatory cell counts in the groups were determined in a standardized 1000 micrometer square area with histomorphometric evaluation.
Biopsies were obtained a day after initial examinations, histological analysis were performed 2 weeks after.
Apoptotic markers
Biopsies were obtained a day after initial examinations, histological analysis were performed 2 weeks after
Hypoxia and tissue destruction markers
Biopsies were obtained a day after initial examinations, histological analysis were performed 2 weeks after
Gingival biopsies of healthy individuals who were never-smokers and had no systemic or oral disease or condition.
Gingival biopsies of periodontitis patients who were never-smokers and had no systemic disease or condition.
Gingival biopsies of healthy individuals who were smokers but no systemic or oral disease or condition.
Gingival biopsies of periodontitis patients who were smokers but no systemic disease or condition.
Healthy individuals who were either smokers or non-smokers, chronic periodontitis patients who were either smokers or non-smokers older than 30 years old and younger than 50 years old were enrolled. The age was specifically chosen because aging changes periodontal and gingival tissues independently of other variables. Any possible factor which might alter connective tissue metabolism were excluded.
Gaziosmanpasa University Faculty of Dentistry
Tokat Province, 60100, Turkey (Türkiye)
Gingival tissue biopsy samples
HATİCE BALCI YÜCE, PhD
Gaziosmanpasa University
60 participants (actual enrollment reported by the registry).
First Submitted
August 13, 2018
First Posted
August 15, 2018
Study Start
January 10, 2017
Actual (reported)Alterations in Subgingival Microbiota and Hypoxia in Occlusal Trauma
Contact the study team to confirm eligibility.
Primary Completion
January 10, 2018
Actual (reported)Study Completion
April 10, 2018
Actual (reported)Last Updated
August 16, 2018
Record last verified: 2018-08
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Source: ClinicalTrials.gov.
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