NCT03625414|Completed
Tissue Alterations in Aggressive and Chronic Periodontitis
Comparison of the Physiologic and Biochemical Alterations in the Healthy and Affected Sites of Chronic and Aggressive Periodontitis Patients
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Comparison of the Physiologic and Biochemical Alterations in the Healthy and Affected Sites of Chronic and Aggressive Periodontitis Patients
Sponsor study identifier
observational
45
1 country
1
Study Start
February 1, 2017
Actual (reported)Primary Completion
February 1, 2018
Actual (reported)Study Completion
June 1, 2018
Actual (reported)Present study intended to compare diseased and healthy sites in chronic and aggressive periodontitis with healthy individuals. The investigators suggest that even unaffected healthy sites of both chronic and aggressive periodontitis patients exhibit subclinical inflammation and tissue destruction with decreased fibroblast cell counts and increased inflammatory cell counts. Investigators also suggest that a possible mechanism which might play a role in the disease progression might occur via a disbalance between matrix metalloproteinases and their inhibitors, and increased hypoxia in diseased sites.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
June 1, 2018
Actual (reported)Click on a node to explore related trials.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
February 1, 2017
Actual (reported)February 1, 2018
Actual (reported)June 1, 2018
Actual (reported)August 7, 2018
Actual (reported)August 10, 2018
Actual (reported)Fibroblast and total inflammatory cell counts
Fibroblast and total inflammatory cell counts in the groups were determined in a standardized 1000 micrometer square area with histomorphometric evaluation.
Biopsies were obtained a day after initial examinations, histological analysis were performed 2 weeks after.
Immunohistochemical staining
Biopsies were obtained a day after initial examinations, histological analysis were performed 2 weeks after
Gingival biopsies of healthy individuals who had no systemic or oral disease or condition.
Chronic periodontitis patients had teeth affected from destruction and some teeth were unaffected. Gingival biopsies of chronic periodontitis patients were taken from sites which were not affected by periodontal destruction.
Chronic periodontitis patients had teeth affected from destruction and some teeth were unaffected. Gingival biopsies of chronic periodontitis patients were taken from sites which were affected by periodontal destruction.
Like chronic periodontitis, aggressive periodontitis patients had also teeth affected by destruction and some teeth were unaffected. Gingival biopsies of aggressive periodontitis patients were taken from sites which were not affected by the periodontal destruction.
Like chronic periodontitis, aggressive periodontitis patients had also teeth affected by destruction and some teeth were unaffected. Gingival biopsies of aggressive periodontitis patients were taken from sites which were affected by the periodontal destruction.
Healthy individuals, chronic periodontitis patients, and localized aggressive periodontitis patients older than 30 years old and younger than 45 years old were enrolled. The age was specifically chosen because aging changes periodontal and gingival tissues independently of other variables. Any possible factor which might alter connective tissue metabolism were excluded.
Gaziosmanpasa University Faculty of Dentistry
Tokat Province, 60100, Turkey (Türkiye)
Gingival biopsies around teeth either affected by periodontal destruction or unaffected. And gingival biopsies of healthy individuals were also obtained.
HATİCE BALCI YÜCE, PhD
Gaziosmanpasa University
45 participants (actual enrollment reported by the registry).
First Submitted
August 7, 2018
First Posted
August 10, 2018
Study Start
February 1, 2017
Actual (reported)Hyaluronic Acid With Scaling & Root Planing In Chronic Periodontitis Patients With Diabetes Mellitus Type 2
Contact the study team to confirm eligibility.
Primary Completion
February 1, 2018
Actual (reported)Study Completion
June 1, 2018
Actual (reported)Last Updated
August 13, 2018
Record last verified: 2018-08
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Source: ClinicalTrials.gov.
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