Defining the Genetic Etiology of Alzheimer's Disease in the Faroe Islands

NCT03628404 | Unknown

• 1 other identifier: AD
• Study Type: observational
• Target: 1,000
• Locations: 1 country
• Sites: 1

Brief Summary

The investigators established the Faroese Alzheimer's Cohort with the aim to unravel genetic and environmental factors that influence the risk and/or susceptibility of Alzheimers disease (AD). It is believed the Faroese population represents a unique opportunity due to its characteristics as a geographic, environmental and genetic isolate with a homogeneous genetic background and founder effects. It has an 'engaged' population with superbly detailed genealogy going 400 years back, unfettered patient access to health care, traditionally high participation rates in research and low probability of losing subjects to follow-up, and presents a unique opportunity to more readily identify genetic and environmental factors involved in AD. The specific aims of this project are:

1. 1.Enrolment of patients with AD, incl.1st degree family members of selected familial patients and age and gender matched control subjects.
2. 2.Detailed genealogical investigation of patients with Alzheimer's disease
3. 3.Identify genes influencing risk and/or susceptibility of AD in the Faroese population

Conditions

Alzheimer Disease; Dementia

Keywords

Alzheimer disease; Dementia; Faroe Islands; Isolated population; Environmental exposure

Outcome Measures

Primary Outcomes (1)

• Sequenom iPLEX genotyping and exome sequencing to identify and characterize genetic contributions to etiology of Alzheimer disease and other dementias

  Genetic cause of disease

  At baseline

Secondary Outcomes (7)

• Influence of polychlorinated biphenyl exposure on the risk of AD

  At baseline

• Influence of perfluorinated alkylated substance exposure on the risk of AD

  At baseline

• Influence of mercury exposure on the risk of AD

  At baseline

• MMSE

  At baseline

• ACE

  At baseline

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

This is a population based study conducted in the Faroe Islands, a small island population with approximately 50.000 inhabitants. Individuals diagnosed with dementia are being recruited from the only Dementia Clinic on the islands. Family members are also recruited. Control subjects are randomly selected from the Faroese Population Registry, matched by sex and age to the cases. Te

You may qualify if:

• diagnosis of dementia (cases)
• Age and gender matched to cases (controls)
• Close relatives to an individual with dementia (family members)

You may not qualify if:

• Sign of dementia assessed by MMSE (controls)

Sponsors & Collaborators

• Faroese Hospital System: lead

Study Sites (1)

The Faroses Hospital System

Tórshavn, 100, Faroe Islands

RECRUITING

Biospecimen

Retention: SAMPLES WITH DNA

Whole blood, serum, plasma and buffy coat

MeSH Terms

Conditions

Alzheimer Disease; Dementia

Condition Hierarchy (Ancestors)

Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Tauopathies; Neurodegenerative Diseases; Neurocognitive Disorders; Mental Disorders

Central Study Contacts

Maria Skaalum Petersen, PhD

CONTACT

00298216695; maria@health.fo

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: OTHER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate professor

Study Record Dates

• First Submitted: August 6, 2018
• First Posted: August 14, 2018
• Study Start: September 1, 2015
• Primary Completion: January 1, 2025
• Study Completion: January 1, 2025
• Last Updated: March 17, 2022

Record last verified: 2022-03

Locations

FA (1)