NCT03638583

Brief Summary

The goal of the Alzheimer Prevention Trials (APT) Webstudy is to accelerate enrollment for Alzheimer's disease (AD) clinical trials by identifying and tracking individuals who may be at higher risk for developing AD dementia.

Trial Health

57
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
200,000

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Dec 2017

Longer than P75 for all trials

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

December 20, 2017

Completed
8 months until next milestone

First Submitted

Initial submission to the registry

August 16, 2018

Completed
4 days until next milestone

First Posted

Study publicly available on registry

August 20, 2018

Completed
7.7 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

April 30, 2026

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

April 30, 2026

Completed
Last Updated

July 16, 2025

Status Verified

July 1, 2025

Enrollment Period

8.4 years

First QC Date

August 16, 2018

Last Update Submit

July 11, 2025

Conditions

Alzheimer DiseaseDementia

Keywords

Alzheimer'sPreventionWeb-Based

Outcome Measures

Primary Outcomes (1)

  • Enrollment into Alzheimer's prevention research studies

    5 years

Secondary Outcomes (2)

  • Referral into prevention research studies

    5 years

  • Number of individuals enrolled into Alzheimer's prevention studies

    5 years

Eligibility Criteria

Age50 Years - 85 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Anyone who meets entry criteria is eligible to join the Webstudy. We anticipate 200,000 individuals will join.

You may qualify if:

  • male or female at least 50 years of age
  • no evidence of dementia
  • willing to participate in remote longitudinal cognitive testing and possible referral for biomarker assessment based on risk

You may not qualify if:

  • N/A. Anyone can register for the APT Webstudy, however, only individuals identified using the risk algorithm will be referred for in-person biomarker assessments.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Https://Www.Aptwebstudy.Org

San Diego, California, 92121, United States

RECRUITING

MeSH Terms

Conditions

Alzheimer DiseaseDementia

Condition Hierarchy (Ancestors)

Brain DiseasesCentral Nervous System DiseasesNervous System DiseasesTauopathiesNeurodegenerative DiseasesNeurocognitive DisordersMental Disorders

Study Officials

  • Paul Aisen, MD

    USC ATRI

    PRINCIPAL INVESTIGATOR

  • Reisa Sperling, MD

    Brigham and Women's Hospital

    PRINCIPAL INVESTIGATOR

  • Jeffrey Cummings, MD

    The Cleveland Clinic

    PRINCIPAL INVESTIGATOR

Central Study Contacts

APT Webstudy Team

CONTACT

858-877-3135info@aptwebstudy.org

Study Design

Study Type
observational
Observational Model
OTHER
Time Perspective
OTHER
Target Duration
5 Years
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Professor

Study Record Dates

First Submitted

August 16, 2018

First Posted

August 20, 2018

Study Start

December 20, 2017

Primary Completion

April 30, 2026

Study Completion

April 30, 2026

Last Updated

July 16, 2025

Record last verified: 2025-07

Data Sharing

IPD Sharing
Will not share

Locations

US(1)