NCT03627351|Completed
Sensory Evaluation of the Taste of Pediatric Medicines
MEDTASTE
Taste of Medicines for Children: Genetic Variation and Medical Adherence (Aim 1)
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MEDTASTE
Taste of Medicines for Children: Genetic Variation and Medical Adherence (Aim 1)
Sponsor study identifier
Secondary identifiers
NIH
observational
154
1 country
1
Study Start
September 1, 2018
Actual (reported)Primary Completion
July 16, 2021
Actual (reported)Study Completion
March 1, 2024
Actual (reported)The investigators will conduct a systematic study of the sensory perception of a diverse set of commonly used pediatric liquid medications and excipients in tandem with an equally complete genetic analysis of the adult sensory panelists to investigate the relationship between genetic variation and individual differences in the perceived flavor (taste, smell, irritation) of pediatric medicines. The flavor of each medicine and excipient will be measured individually using both cognitively demanding methods unsuitable for young children and simpler measures validated for use by children. Salivary DNA samples will be collected to carry out genome wide association study (GWAS).
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
March 1, 2024
Actual (reported)Click on a node to explore related trials.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
July 9, 2018
Actual (reported)August 13, 2018
Actual (reported)September 1, 2018
Actual (reported)July 16, 2021
Actual (reported)March 1, 2024
Actual (reported)Flavor ratings (using general labelled magnitude scale, gLMS) of pediatric medicines and excipients
Flavor ratings of each pediatric medicine and excipient as assessed by the general labelled magnitude scale \[gLMS\]; each medicine and each excipient is rated individually; range 0 \[minimum, no flavor\] to 100 \[maximum; strongest flavor rating\]
Through study completion, an average of 3 years
Palatability ratings (using hedonic general labelled magnitude scale, hedonic gLMS) of the flavor of pediatric medicines and excipients
Ratings of the palatabillity of the flavor of each medicine and excipient, as assessed by the hedonic general labelled magnitude scale; each medicine and each excipient is rated individually, range: -100 \[minimum palatability rating\] to 0 \[neither like nor dislike\] to 100 \[maximum /strongest imaginable palatability ratings\]
Through study completion, an average of 3 years
Detect genetic associations (GWAS) with flavor and palatability ratings of pediatric medicines
To detect genetic associations with taste and palatability ratings phenotypes of each medicine
After study completion, 2021-2022
Hedonic ratings (using 5 face scale) of the flavor of pediatric medicines
Through study completion, an average of 3 years
Group of healthy women and men
Healthy men and women between the ages of 18 and 55 years
Monell Chemical Senses Center
Philadelphia, Pennsylvania, 19104, United States
Mennella JA, Mathew PS, Lowenthal ED. Use of Adult Sensory Panel to Study Individual Differences in the Palatability of a Pediatric HIV Treatment Drug. Clin Ther. 2017 Oct;39(10):2038-2048. doi: 10.1016/j.clinthera.2017.08.012. Epub 2017 Sep 18.
Mennella JA, Spector AC, Reed DR, Coldwell SE. The bad taste of medicines: overview of basic research on bitter taste. Clin Ther. 2013 Aug;35(8):1225-46. doi: 10.1016/j.clinthera.2013.06.007. Epub 2013 Jul 22.
Identification of genetic polymorphisms in DNA from saliva samples collected at baseline that are associated with variation in flavor and palatability ratings of pediatric medicines through genome wide association study of adult panelists
Julie A. Mennella, PhD
Monell Chemical Senses Center
Elizabeth Lowenthal, MD
Children's Hospital of Philadelphia
154 participants (actual enrollment reported by the registry).
First Submitted
July 9, 2018
First Posted
August 13, 2018
Study Start
September 1, 2018
Actual (reported)Variation in Urine Electrolytes, pH and Specific Gravity Throughout the Day
Contact the study team to confirm eligibility.
Kalva JJ, Sims CA, Puentes LA, Snyder DJ, Bartoshuk LM. Comparison of the hedonic general Labeled Magnitude Scale with the hedonic 9-point scale. J Food Sci. 2014 Feb;79(2):S238-45. doi: 10.1111/1750-3841.12342. Epub 2014 Jan 14.
Snyder DJ, Prescott J, Bartoshuk LM. Modern psychophysics and the assessment of human oral sensation. Adv Otorhinolaryngol. 2006;63:221-241. doi: 10.1159/000093762.
Bobowski N, Mennella JA. Personal Variation in Preference for Sweetness: Effects of Age and Obesity. Child Obes. 2017 Oct;13(5):369-376. doi: 10.1089/chi.2017.0023. Epub 2017 May 12.
Bobowski N, Reed DR, Mennella JA. Variation in the TAS2R31 bitter taste receptor gene relates to liking for the nonnutritive sweetener Acesulfame-K among children and adults. Sci Rep. 2016 Dec 14;6:39135. doi: 10.1038/srep39135.
Kan M, Saraiva LR, Hwang LD, Lowenthal ED, Himes BE, Mennella JA. Genome-wide association study of the taste and hedonic ratings of the low-calorie sweetener acesulfame potassium. Sci Rep. 2025 Jul 1;15(1):22121. doi: 10.1038/s41598-025-05739-x.
Primary Completion
July 16, 2021
Actual (reported)Study Completion
March 1, 2024
Actual (reported)Last Updated
March 4, 2024
Record last verified: 2024-03
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