NCT05047588|Completed
Added Sugar Intake, Sweet Taste Phenotypes and Biomarkers
SWBIO
Stable Isotope Biomarker for Added Sugar Intake and Sweet Taste Phenotypes in Mother-child Dyads
Loading search results
SWBIO
Stable Isotope Biomarker for Added Sugar Intake and Sweet Taste Phenotypes in Mother-child Dyads
Sponsor study identifier
observational
277
1 country
1
Study Start
August 29, 2019
Actual (reported)Primary Completion
November 9, 2021
Actual (reported)Study Completion
September 1, 2022
Actual (reported)The goals of this cross-sectional study on a racially diverse group of children (3-10y) and their mothers are to determine whether the relationship between sweet taste phenotypes differed among mother-daughter and mother-son dyads and to determine the predictive value of a hair biomarker (delta13C). Given the widespread overconsumption of added sugars, and the associated burden of disease, improving surveillance measures and developing strategies to reduce added sugar intake, especially among the youngest members of society, are public health priorities.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
September 1, 2022
Actual (reported)Click on a node to explore related trials.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
August 29, 2019
Actual (reported)August 13, 2021
Actual (reported)September 17, 2021
Actual (reported)November 9, 2021
Actual (reported)September 1, 2022
Actual (reported)Sweet taste preferences
Level of sucrose most preferred as determined by the Monell forced-choice tracking method \[range of sucrose solutions: 0.09 to 1.05 M\]
Through study completion, average 2 and a half years
Diet intake
Two days of dietary intake will be obtained by having mothers report all the foods and beverage eaten during past day using the Automated Self-Administered Recall System (ASA24). Mothers will complete for herself and her child on two separate days. From these data, we will obtain daily energy intake (kcal/d), sugar (g/d; kcal/d) intake
Through study completion, average 2 and a half years
PALS/ALS Liking surveys
Liking of different types of foods will by assessed by Preschool Adapted Liking Survey (PALS) for children \[range -100 (maximal dislike) to 100 (maximal like)\] and the Adult Liking Survey (ALS) for adults \[range -100 (maximal dislike) to 100 (maximal like)\]
Through study completion, average 2 and a half years
Hair Biomarker for added sugar intake
Three cm of each hair sample will undergo stable isotope ratio mass spectrometry that will yield the concentration of carbon-13 relative to carbon-12 (added sugar biomarker, which has been shown to be associated with added sugar intake in older children and adults. Each cm reflects the added sugar intake of one month.
After study completion, 2022
Anthropometry
Through study completion, average 2 and a half years
Eating Behavior constructs
Through study completion, average 2 and a half years
Waist-to-Hip ratio
Through study completion, average 2 and a half years
Healthy adults and children
Monell Chemical Senses Center
Philadelphia, Pennsylvania, 19104, United States
Smethers AD, Fisher JO, Carney EM, Coffman DL, Mennella JA. Carbon stable isotope values in hair are associated with added sugar intake in adults but not young children: a cross-sectional study. Am J Clin Nutr. 2025 Apr;121(4):900-909. doi: 10.1016/j.ajcnut.2025.02.013. Epub 2025 Feb 18.
Julie A Mennella, PhD
Monell Chemical Senses Center
Alissa D Smethers, RD PhD
Monell Chemical Senses Center
277 participants (actual enrollment reported by the registry).
First Submitted
August 13, 2021
First Posted
September 17, 2021
Study Start
August 29, 2019
Actual (reported)Contact the study team to confirm eligibility.
Primary Completion
November 9, 2021
Actual (reported)Study Completion
September 1, 2022
Actual (reported)Last Updated
February 3, 2023
Record last verified: 2023-02
Download the complete ClinicalTrials.gov record imported by Syfrah, including fields not shown in this page. The registry may contain a newer revision.
Source: ClinicalTrials.gov.
JSON downloads include source attribution and retrieval details alongside the unchanged original record or the separately normalized values.
Source retrieved: