A Systematic Investigation of Phonetic Complexity Effects on Articulatory Motor Performance in Progressive Dysarthria
Understanding Communication and Cognitive Impairments in Neurodegenerative Disorders
2 other identifiers
interventional
100
1 country
2
Brief Summary
The goal is to improve the fundamental knowledge about articulatory motor performance in people with Lou Gehrig's disease (also known as ALS) and Parkinson's disease (PD), in order to develop more sensitive assessments for progressive speech loss, which may lead to the improved timing of speech therapies.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for not_applicable
Started Jul 2017
Longer than P75 for not_applicable
2 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
July 15, 2017
CompletedFirst Submitted
Initial submission to the registry
July 10, 2018
CompletedFirst Posted
Study publicly available on registry
August 2, 2018
CompletedPrimary Completion
Last participant's last visit for primary outcome
February 28, 2022
CompletedStudy Completion
Last participant's last visit for all outcomes
February 28, 2022
CompletedMay 17, 2022
May 1, 2022
4.6 years
July 10, 2018
May 16, 2022
Conditions
Keywords
Outcome Measures
Primary Outcomes (5)
Peak movement speed
Peak speed (millimeters/second) for each articulatory marker is the maximum value of the first-order derivative of each marker's Euclidean distance time-history.
Up to 3 months after enrollment
Range of movement
The convex hull represents the smallest convex set containing all the points in the 3D motion path.
Up to 3 months after enrollment
Duration
Word duration (seconds) is the time between onset and offset of movement for each word.
Up to 3 months after enrollment
Spatiotemporal movement variability (STI)
STI is the most widely used metric to capture movement pattern variability during speech. To determine STI, the pattern of articulatory movements and the variability of that pattern over several repetitions of an utterance are examined.
Up to 3 months after enrollment
Inter-articulator coordination
Spatiotemporal coupling relations between articulators will be derived from vertical movements of the articulators using a covariance measure.
Up to 3 months after enrollment
Study Arms (1)
Phonetic complexity effects
OTHERConduct a comprehensive kinematic assessment using state-of-the art 3D speech tracking technology on individuals with ALS and PD as well as healthy talkers to identify articulatory motor disturbances as a function of phonetic complexity and dysarthria severity. Phonetic complexity will be experimentally manipulated using the consonant and vowel complexity classification system proposed by Kent (1992) that takes into account the underlying articulatory motor adjustments required to produce various speech sounds.
Interventions
Use of 3D electromagnetic articulography to examine phonetic complexity effects of single word stimuli at the articulatory kinematic level in talkers each with preclinical, mild, and moderate dysarthria, relative to healthy controls.
Eligibility Criteria
You may qualify if:
- May or may not have a neurological impairment.
- Age range of 19-90 years.
- Male or female.
- Provide written consent before any study specific procedures are performed.
- Have ability to comply with basic instructions.
- Monolingual English speaker.
- Have ability to partake in a 90 minute data collection.
You may not qualify if:
- Any speech, language, cognition, or hearing impairment prior to diagnosis of a neurodegenerative disease.
- Anyone not appropriate for study participation, as deemed by the principal investigator.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (2)
University of Kansas Medical Center
Fairway, Kansas, 66205, United States
University of Missouri-Columbia
Columbia, Missouri, 65211, United States
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Mili Kuruvilla-Dugdale, PhD
University of Missouri-Columbia
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NA
- Masking
- NONE
- Purpose
- BASIC SCIENCE
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Assistant Professor
Study Record Dates
First Submitted
July 10, 2018
First Posted
August 2, 2018
Study Start
July 15, 2017
Primary Completion
February 28, 2022
Study Completion
February 28, 2022
Last Updated
May 17, 2022
Record last verified: 2022-05
Data Sharing
- IPD Sharing
- Will share
- Shared Documents
- STUDY PROTOCOL, SAP
- Time Frame
- Data will be ensured as soon as the study starts and even after the study ends.
- Access Criteria
- Data will only be shared for research purposes.
The data collected during this study, especially from people with ALS, cannot be easily duplicated so it will be readily shared with other researchers conducting motor speech research. In addition, few investigators have access to tongue tracking technology; therefore, making the tongue kinematic data available will allow other investigators to answer pertinent questions related to speech decline in progressive dysarthrias. Both the raw data and processed data will be made available to interested investigators but will be devoid of identifiers in order to protect the privacy of the participants. Data documentation such as descriptors and units will also be shared to prevent misinterpretation or confusion. Besides the data itself, the PI is willing to share the stimuli as requested by other investigators.