Exercise and Pain in Non-Hispanic Blacks and Whites

NCT03609957 | Withdrawn DMC

• 1 other identifier: R01HL141205
• Study Type: interventional
• Target: N/A
• Locations: 1 country
• Sites: 1

Brief Summary

Non-Hispanic Blacks tend to report higher levels of pain, experience pain more frequently, and be under-treated for pain compared to non-Hispanic Whites. Acute (single session) exercise is known to be effective at reducing pain but it is unknown what effect chronic exercise training has on pain responses. The broad goal of this study is to determine whether regular exercise training is more effective at reducing pain responses in non-Hispanic Blacks compared to non-Hispanic Whites. The investigators are interested in comparing regular aerobic exercise training versus high-intensity interval training.

Conditions

Pain, Acute; Pain, Neuropathic; Analgesia; Aerobic Exercise; Exercise Training

Outcome Measures

Primary Outcomes (1)

• Change in skin blood flow response to local heating

  Vasodilation in response to painful and non-painful heating of the skin

  Baseline (prior to intervention or control) and at the conclusion of the 5-week intervention or control. The post-intervention assessment will be performed no later than 3-5 days after completion of the 5-week intervention or control.

Study Arms (3)

Aerobic Exercise Training

EXPERIMENTAL

Moderate intensity (75% heart rate reserve) cycling exercise for 32 minutes, 3 days per week for 5 weeks

Other: Aerobic Exercise Training

Interval Training

EXPERIMENTAL

High intensity (95% heart rate reserve) cycling exercise for 20 minutes, 3 days per week for 5 weeks

Other: Interval Training

Control

NO INTERVENTION

Control (no exercise intervention) group

Interventions

Aerobic Exercise Training OTHER

Traditional, continuous aerobic exercise (cycling) at a moderate intensity

Aerobic Exercise Training

Interval Training OTHER

High-intensity interval exercise consisting of short bursts of exercise interspersed with rest periods

Interval Training

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Healthy
• Normotensive
• Identify as non-Hispanic Black or non-Hispanic White
• Healthy enough to participate in regular exercise
• Not taking any medications other than birth control

You may not qualify if:

• Heart disease (high blood pressure, previous stroke or heart attack)
• Type 1 or 2 diabetes
• History of cancer treated with chemotherapy
• History of nerve damage
• History of chronic pain
• Current smoker/tobacco user or quit less than 1 year ago
• Skin disorders (psoriasis, etc.)
• Pregnant
• Taking any medications other than birth control

Sponsors & Collaborators

• Georgia State University: lead

Study Sites (1)

Georgia State University

Atlanta, Georgia, 30303, United States

Location

Related Publications (44)

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MeSH Terms

Conditions

Acute Pain; Neuralgia; Agnosia

Interventions

High-Intensity Interval Training

Condition Hierarchy (Ancestors)

Pain; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Peripheral Nervous System Diseases; Neuromuscular Diseases; Nervous System Diseases; Perceptual Disorders; Neurobehavioral Manifestations

Intervention Hierarchy (Ancestors)

Physical Conditioning, Human; Exercise; Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Brett J Wong, Ph.D.

  Georgia State University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: FACTORIAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: July 11, 2018
• First Posted: August 1, 2018
• Study Start: February 1, 2019
• Primary Completion: December 1, 2019
• Study Completion: December 1, 2019
• Last Updated: December 11, 2018

Record last verified: 2018-12

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)