NCT03606603

Brief Summary

This is an observational, cross-sectional study to be conducted on the Nutrition Insights Day (NID), with retrospective review of patient medical charts. No prospective follow-up period is considered. This study aims to obtain a contemporary overview of the nutritional status, the use of EN and/or PN and the provision of calories and proteins in patients after major elective gastrointestinal surgery with existing malnutrition or at risk of hospital malnutrition in selected Asian countries.

Trial Health

93
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
590

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Mar 2019

Shorter than P25 for all trials

Geographic Reach
7 countries

89 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

July 23, 2018

Completed
8 days until next milestone

First Posted

Study publicly available on registry

July 31, 2018

Completed
8 months until next milestone

Study Start

First participant enrolled

March 15, 2019

Completed
3 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 18, 2019

Completed
10 days until next milestone

Study Completion

Last participant's last visit for all outcomes

June 28, 2019

Completed
Last Updated

July 5, 2019

Status Verified

July 1, 2019

Enrollment Period

3 months

First QC Date

July 23, 2018

Last Update Submit

July 2, 2019

Conditions

Keywords

nutritional statusmalnutritionenergy intakeprotein intakeICUsurgical wardhospitalenteral nutritionparenteral nutritionnutrition

Outcome Measures

Primary Outcomes (1)

  • Proportion of surgical patients with a caloric / protein deficit receiving EN and/or PN on the day before the NID in selected Asian countries.

    Caloric / protein deficit, i.e., difference between energy / protein target per day and actually administered energy/protein

    On the day before the Nutrition Insights Day (day -1)

Secondary Outcomes (4)

  • Absolute and relative caloric and protein balance

    On the day before the Nutrition Insights Day (day -1)

  • Distribution within subcategories of caloric / protein balance

    On the day before the Nutrition Insights Day (day -1)

  • Cumulative (absolute/ relative) caloric and protein balance

    On the day before the Nutrition Insights Day (day -1)

  • Categorical, absolute and relative caloric balance based on standardized target intake (sensitivity analysis)

    On the day before the Nutrition Insights Day (day -1)

Study Arms (1)

Surgical patients

Adult patients after elective major abdominal gastrointestinal surgery with pre-existing malnutrition or who are at significant risk for malnutrition or nutrition-related complications, with indications for nutritional support

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Adult patients after elective major abdominal gastrointestinal surgery with pre-existing malnutrition or who are at significant risk for malnutrition or nutrition-related complications, with indications for nutritional support

You may qualify if:

  • Adult patients after elective major abdominal gastrointestinal surgery \[i.e. elective major GI resections, partial or total, especially for cancer, including: esophagectomy, gastrectomy, enterectomy (small bowel resection), colectomy, hepatectomy, pancreatectomy, resections for gall bladder or bile duct cancer (cholangiocarcinoma)\] with pre-existing malnutrition or who are at significant risk for malnutrition or nutrition-related complications\*, with indications for nutritional support
  • Hospitalization on SICU or major surgical ward on the NID
  • Use of EN (nutritional intake provided via tube feeding) and/or PN for at least one day before the NID
  • If patient received oral nutrition (ON) or oral nutrition supplements (ONS) during the observational phase from day -5 to day -2, complete and reliable data of daily caloric and protein intake is available
  • Latest surgical intervention ≤ 10 days before NID

You may not qualify if:

  • Patients with burn injuries
  • Patients requiring postsurgical mechanical ventilation and sedation on the NID
  • Patients receiving ON and/or ONS at any quantity on the day before the NID
  • Patients requiring emergency procedures

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (89)

Manipal Hospital

Bangalore, India

Location

Bombay Hospital

Bombay, India

Location

Apollo Hospitals

Chennai, India

Location

SIMS (SRM Institutes for Medical Science)

Chennai, India

Location

G. Kuppuswamy Naidu Memorial Hospital

Coimbatore, India

Location

Max Super Speciality Hospital

Dehli, India

Location

Sir Ganga Ram Hospital

Dehli, India

Location

AMRI Hospital

Dhakuria, India

Location

Fortis Memorial Research Institute

Gūrgaon, India

Location

Medanta Medicity Hospital

Gūrgaon, India

Location

Care Hospital

Hyderabad, India

Location

Rukmani Birla Hospital, A Unit of CMRI

Jaipur, India

Location

Rukmani Birla Hospital

Jaipur, India

Location

Apollo Gleneagles Hospitals Ltd.

Kolkata, India

Location

Dayanand Medical College and Hospital

Ludhiana, India

Location

Fortis Hospital

Mohali, India

Location

Max Superspecialty Hospital

Mohali, India

Location

B. Y. L. Nair Charitable Hospital & Topiwala National Medical College

Mumbai, India

Location

S.L Raheja - A Fortis Associate Hospital

Mumbai, India

Location

BLK Super Specialty Hospital

New Delhi, India

Location

Jawaharlal Institute Of Post Graduate Medical Education Medical Education and Research (JIPMER)

Puducherry, India

Location

Deenanath Mangeshkar Hospital

Pune, India

Location

Ruby Hall Clinic

Pune, India

Location

Krishna Institute of Medical Sciences

Secunderabad, India

Location

Surat Institute of Digestive Sciences

Sūrat, India

Location

Geetanjali Medical College

Udaipur, India

Location

Christian Medical College & Hospital

Vellore, India

Location

Cipto Mangunkusumo Hospital

Jakarta, Indonesia

Location

Dharmais Cancer Center

Jakarta, Indonesia

Location

Rumah Sakit Persahabatan

Jakarta, Indonesia

Location

Siloam Hospitals Kebon Jeruk

Jeruk, Indonesia

Location

Kariadi Hospital

Semarang, Indonesia

Location

Telogorejo Hospital

Semarang, Indonesia

Location

Mitra Keluarga Waru Hospital

Waru, Indonesia

Location

Bethesda Hospital

Yogyakarta, Indonesia

Location

Sardjito Hospital

Yogyakarta, Indonesia

Location

Capitol University Medical Center

Cagayan de Oro, Philippines

Location

Cebu Doctors University Hospital

Cebu City, Philippines

Location

Perpetual Succour Hospital

Cebu City, Philippines

Location

De La Salle University Medical Center

Dasmariñas, Philippines

Location

Southern Philippines Medical Center

Davao City, Philippines

Location

Makati Medical Center

Makati City, Philippines

Location

Asian Hospital and Medical Center

Manila, Philippines

Location

Dr. Jose R.Reyes Memorial Medical Center

Manila, Philippines

Location

Manila Doctors Hospital

Manila, Philippines

Location

Philippine General Hospital

Manila, Philippines

Location

St. Luke's Medical Center Global City

Manila, Philippines

Location

University of Santo Tomas

Manila, Philippines

Location

The Medical City

Pasig, Philippines

Location

East Avenue Medical Center

Quezon City, Philippines

Location

National Kidney and Transplant Institute

Quezon City, Philippines

Location

Quirino Memorial Medical Center

Quezon City, Philippines

Location

St. Luke's Medical Center

Quezon City, Philippines

Location

Jose B.Lingad Memorial Regional Memorial Hspl

San Fernando City, Philippines

Location

Daegu Catholic University Medical Center

Daegu, South Korea

Location

Keimyung University Dongsan Hospital

Daegu, South Korea

Location

National Cancer Center

Goyang-si, South Korea

Location

Chungnam National University Hospital

Jungnam, South Korea

Location

Seoul National University Bundang Hospital

Seoul, South Korea

Location

Seoul National University Hospital

Seoul, South Korea

Location

Sungkunkwan University Samsung Medical Center

Seoul, South Korea

Location

The Catholic University of Korea, Seoul St. Mary's Hospital

Seoul, South Korea

Location

Ulsan University Hospital, Asan Medical Center

Ulsan, South Korea

Location

Changhua Christian Medical Foundation Changhua Christian Hospital

Chang-hua, Taiwan

Location

Chang Gung Memorial Hospital- Kaoshiung Branch

Kaohsiung City, Taiwan

Location

E-DA Hospital

Kaohsiung City, Taiwan

Location

Kaohsiung Veterans General Hospital

Kaohsiung City, Taiwan

Location

Chang Gung Memorial Hospital

Linkou District, Taiwan

Location

Chung Shan Medical University Hospital

Taichung, Taiwan

Location

Taichung Veterans General Hospital

Taichung, Taiwan

Location

National Taiwan University Hospital

Taipei, Taiwan

Location

Taipei Veterans General Hospital

Taipei, Taiwan

Location

Bhumibol Adulyadej Hospital

Bangkok, Thailand

Location

King Chulalongkorn Memorial Hospital

Bangkok, Thailand

Location

Rajavithi Hospital

Bangkok, Thailand

Location

Ramathibodi Hospital

Bangkok, Thailand

Location

Srinakarin Hospital

Bangkok, Thailand

Location

Thammasat University Hospital

Bangkok, Thailand

Location

Maharaj Nakorn Chiang Mai Hospital

Chiang Mai, Thailand

Location

Songkla Nakarin Hospital

Hat Yai, Thailand

Location

Siriraj Hospital

Phuket, Thailand

Location

Surin Hospital

Surin, Thailand

Location

108 Military Central Hospital

Hanoi, Vietnam

Location

Bach Mai Hospital

Hanoi, Vietnam

Location

Cho Ray Hospital

Ho Chi Minh City, Vietnam

Location

HCM city University Medical Center

Ho Chi Minh City, Vietnam

Location

People's Hospital 115

Ho Chi Minh City, Vietnam

Location

Thong Nhat Hospital

Ho Chi Minh City, Vietnam

Location

Hue Central Hospital

Huế, Vietnam

Location

Related Publications (13)

  • Detsky AS, McLaughlin JR, Baker JP, Johnston N, Whittaker S, Mendelson RA, Jeejeebhoy KN. What is subjective global assessment of nutritional status? JPEN J Parenter Enteral Nutr. 1987 Jan-Feb;11(1):8-13. doi: 10.1177/014860718701100108.

  • Higashiguchi T, Arai H, Claytor LH, Kuzuya M, Kotani J, Lee SD, Michel JP, Nogami T, Peng N. Taking action against malnutrition in Asian healthcare settings: an initiative of a Northeast Asia Study Group. Asia Pac J Clin Nutr. 2017 Mar;26(2):202-211. doi: 10.6133/apjcn.022016.04.

  • Ho JW, Wu AH, Lee MW, Lau SY, Lam PS, Lau WS, Kwok SS, Kwan RY, Lam CF, Tam CK, Lee SO. Malnutrition risk predicts surgical outcomes in patients undergoing gastrointestinal operations: Results of a prospective study. Clin Nutr. 2015 Aug;34(4):679-84. doi: 10.1016/j.clnu.2014.07.012. Epub 2014 Aug 1.

  • Jia ZY, Yang J, Tong DN, Peng JY, Zhang ZW, Liu WJ, Xia Y, Qin HL. Screening of nutritional risk and nutritional support in general surgery patients: a survey from Shanghai, China. Int Surg. 2015 May;100(5):841-8. doi: 10.9738/INTSURG-D-14-00245.1.

  • Kondrup J, Rasmussen HH, Hamberg O, Stanga Z; Ad Hoc ESPEN Working Group. Nutritional risk screening (NRS 2002): a new method based on an analysis of controlled clinical trials. Clin Nutr. 2003 Jun;22(3):321-36. doi: 10.1016/s0261-5614(02)00214-5.

  • Linthicum MT, Thornton Snider J, Vaithianathan R, Wu Y, LaVallee C, Lakdawalla DN, Benner JE, Philipson TJ. Economic burden of disease-associated malnutrition in China. Asia Pac J Public Health. 2015 May;27(4):407-17. doi: 10.1177/1010539514552702. Epub 2014 Oct 8.

  • Liu X, Xu P, Qiu H, Xu D, Li W, Zhan Y, Li Y, Chen Y, Zhou Z, Sun X. Preoperative Nutritional Deficiency Is a Useful Predictor of Postoperative Outcome in Patients Undergoing Curative Resection for Gastric Cancer. Transl Oncol. 2016 Dec;9(6):482-488. doi: 10.1016/j.tranon.2016.09.008. Epub 2016 Oct 24.

  • Nakahara S, Nguyen DH, Bui AT, Sugiyama M, Ichikawa M, Sakamoto T, Nakamura T. Perioperative nutrition management as an important component of surgical capacity in low- and middle-income countries. Trop Med Int Health. 2017 Jul;22(7):784-796. doi: 10.1111/tmi.12892. Epub 2017 Jun 13.

  • Norman K, Pichard C, Lochs H, Pirlich M. Prognostic impact of disease-related malnutrition. Clin Nutr. 2008 Feb;27(1):5-15. doi: 10.1016/j.clnu.2007.10.007. Epub 2007 Dec 3.

  • Sun Z, Kong XJ, Jing X, Deng RJ, Tian ZB. Nutritional Risk Screening 2002 as a Predictor of Postoperative Outcomes in Patients Undergoing Abdominal Surgery: A Systematic Review and Meta-Analysis of Prospective Cohort Studies. PLoS One. 2015 Jul 14;10(7):e0132857. doi: 10.1371/journal.pone.0132857. eCollection 2015.

  • Vallejo KP, Martinez CM, Matos Adames AA, Fuchs-Tarlovsky V, Nogales GCC, Paz RER, Perman MI, Correia MITD, Waitzberg DL. Current clinical nutrition practices in critically ill patients in Latin America: a multinational observational study. Crit Care. 2017 Aug 25;21(1):227. doi: 10.1186/s13054-017-1805-z.

  • Waitzberg DL, Caiaffa WT, Correia MI. Hospital malnutrition: the Brazilian national survey (IBRANUTRI): a study of 4000 patients. Nutrition. 2001 Jul-Aug;17(7-8):573-80. doi: 10.1016/s0899-9007(01)00573-1.

  • Zhong JX, Kang K, Shu XL. Effect of nutritional support on clinical outcomes in perioperative malnourished patients: a meta-analysis. Asia Pac J Clin Nutr. 2015;24(3):367-78. doi: 10.6133/apjcn.2015.24.3.20.

MeSH Terms

Conditions

MalnutritionProtein DeficiencyHyperphagia

Condition Hierarchy (Ancestors)

Nutrition DisordersNutritional and Metabolic DiseasesDeficiency DiseasesSigns and Symptoms, DigestiveSigns and SymptomsPathological Conditions, Signs and Symptoms

Study Officials

  • John F Stover, M.D.

    Fresenius Kabi

    STUDY CHAIR

Study Design

Study Type
observational
Observational Model
OTHER
Time Perspective
RETROSPECTIVE
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

July 23, 2018

First Posted

July 31, 2018

Study Start

March 15, 2019

Primary Completion

June 18, 2019

Study Completion

June 28, 2019

Last Updated

July 5, 2019

Record last verified: 2019-07

Data Sharing

IPD Sharing
Will not share

Locations