Navigated Repetitive Transcranial Magnetic Stimulation in Improving Motor Rehabilitation in Participants With Brain Tumors

NCT03606161 | Active Not Recruiting

• 2 other identifiers: 2018-0269NCI-2018-01476
• Study Type: interventional
• Target: 32
• Locations: 1 country
• Sites: 1

Brief Summary

This trial studies how well navigated repetitive transcranial magnetic stimulation works in improving motor rehabilitation in participants with brain tumors. Navigated repetitive transcranial magnetic stimulation may help improve patients' lost motor function after surgery.

Conditions

Brain Neoplasm

Outcome Measures

Primary Outcomes (1)

• Intervention adherence

  Will be defined as a participant as completing at least 70% of the (i.e., seven out of 10) treatment sessions. Feasibility will be defined as: 1) at least 70% of the participants adhere to the treatment. Patients will have to finish all 10 trains in each navigated repetitive transcranial magnetic stimulation (nrTMS) run in order to be considered complete; 2) at least 37% of the eligible patients (at a rate of approximately 3/8 per month) enroll in the study.

  Up to 3 months

Other Outcomes (2)

• Motor recovery

  Up to 3 months

• Changes in cortical activity

  Baseline up to 3 months

Study Arms (1)

Supportive care (nrTMS)

EXPERIMENTAL

Between 1-7 days after standard of care surgery, participants undergo 10 nrTMS sessions over 30 minutes each over 3 weeks.

Other: Questionnaire Administration; Procedure: Transcranial Magnetic Stimulation

Interventions

Questionnaire Administration OTHER

Ancillary studies

Supportive care (nrTMS)

Transcranial Magnetic Stimulation PROCEDURE

Undergo nrTMS

Also known as: TMS

Supportive care (nrTMS)

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients with brain tumors associated with the motor cortex
• Understand and read English, sign a written informed consent, and be willing to follow protocol requirements
• Eastern Cooperative Oncology Group (ECOG) performance status of 0-2
• Motor impairment must be related to the surgical procedure or the tumor itself (in the opinion of the treating physician)
• Patients who are within 7 days of brain tumor resection associated with the motor cortex
• Eligibility for the nrTMS treatment will be based on motor ability and will be determined postoperatively by the surgeon

You may not qualify if:

• Patients who are taking any antipsychotic medications
• Patients who have ever been diagnosed with bipolar disorder or schizophrenia
• Patients with a history of stroke

Sponsors & Collaborators

• M.D. Anderson Cancer Center: lead
• National Cancer Institute (NCI): collaborator

Study Sites (1)

M D Anderson Cancer Center

Houston, Texas, 77030, United States

Location

Related Links

• M D Anderson Cancer Center

MeSH Terms

Conditions

Brain Neoplasms

Interventions

Transcranial Magnetic Stimulation

Condition Hierarchy (Ancestors)

Central Nervous System Neoplasms; Nervous System Neoplasms; Neoplasms by Site; Neoplasms; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases

Intervention Hierarchy (Ancestors)

Magnetic Field Therapy; Therapeutics

Study Officials

• Sarah Prinsloo

  M.D. Anderson Cancer Center

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: SUPPORTIVE CARE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 20, 2018
• First Posted: July 30, 2018
• Study Start: August 23, 2018
• Primary Completion (Estimated): December 31, 2027
• Study Completion (Estimated): December 31, 2027
• Last Updated: February 19, 2026

Record last verified: 2026-02

Locations

US (1)