TMS - Intracranial Electrodes
Investigating the Effects of Transcranial Magnetic Stimulation With Intracranial EEG in Humans
2 other identifiers
interventional
50
1 country
1
Brief Summary
This is a study looking at the effects of transcranial magnetic stimulation (TMS), a form of non-invasive brain stimulation (NIBS), on the human brain as recorded by intracranial electroencephalography in neurosurgical patients. NIBS will be applied in a targeted manner and brain responses will be recorded.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for not_applicable
Started Jul 2019
Longer than P75 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
October 8, 2018
CompletedFirst Posted
Study publicly available on registry
October 10, 2018
CompletedStudy Start
First participant enrolled
July 16, 2019
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 30, 2026
ExpectedStudy Completion
Last participant's last visit for all outcomes
July 30, 2026
June 12, 2025
May 1, 2025
7 years
October 8, 2018
June 10, 2025
Conditions
Outcome Measures
Primary Outcomes (1)
Change in brain activity assessed with intracranial EEG
Activity changes within seconds of the stimulation
Study Arms (1)
TMS in patients with intracranial electrodes
EXPERIMENTALWe will administer TMS to neurosurgical patients with intracranial electroencephalography in order to better understand the effects TMS has on the human brain. Participants will receive both active and sham stimulation at varying points during the study.
Interventions
NIBS is applied to the brain.
Eligibility Criteria
You may qualify if:
- Eligible subjects will include neurosurgery patients (age 18 and above) who have implantation of intracranial electrodes and undergo long term (about 2 weeks) EEG monitoring in order to decide candidacy for surgical resection of seizure foci. They must have the cognitive capacity to understand the risks and benefits fo the study and provide consent.
You may not qualify if:
- Those who are known to have neurological or psychiatric disorder other than primary disease for which patients have surgery will be excluded.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Aaron Boeslead
- Stanford Universitycollaborator
- National Institute of Mental Health (NIMH)collaborator
Study Sites (1)
University of Iowa
Iowa City, Iowa, 52242, United States
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Aaron Boes, MD, PhD
University of Iowa
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NA
- Masking
- NONE
- Masking Details
- Participant will receive active and sham stimulation at varying points during the study.
- Purpose
- BASIC SCIENCE
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR INVESTIGATOR
- PI Title
- Assistant Professor
Study Record Dates
First Submitted
October 8, 2018
First Posted
October 10, 2018
Study Start
July 16, 2019
Primary Completion (Estimated)
June 30, 2026
Study Completion (Estimated)
July 30, 2026
Last Updated
June 12, 2025
Record last verified: 2025-05
Data Sharing
- IPD Sharing
- Will not share