NCT03600883

Brief Summary

Evaluate the safety and tolerability of sotorasib in adult subjects with KRAS p.G12C mutant advanced solid tumors. Estimate the maximum tolerated dose (MTD) and/or a recommended phase 2 dose (RP2D) in adult subjects with KRAS p.G12C mutant advanced solid tumors.

Trial Health

98
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Strong global presence with extensive site network
Enrollment
713

participants targeted

Target at P75+ for phase_1

Timeline
Completed

Started Aug 2018

Longer than P75 for phase_1

Geographic Reach
15 countries

129 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

June 26, 2018

Completed
1 month until next milestone

First Posted

Study publicly available on registry

July 26, 2018

Completed
1 month until next milestone

Study Start

First participant enrolled

August 27, 2018

Completed
7.8 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

May 29, 2026

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

May 29, 2026

Completed
Last Updated

June 30, 2026

Status Verified

June 1, 2026

Enrollment Period

7.8 years

First QC Date

June 26, 2018

Last Update Submit

June 29, 2026

Conditions

Outcome Measures

Primary Outcomes (15)

  • Primary: Number of subjects with treatment-emergent adverse events

    Treatment-emergent adverse events will be a primary outcome measure for the following groups: * Phase 1 Dose Exploration Part 1 monotherapy * Phase 1 Dose Expansion Part 2 monotherapy * Phase 1 combination arm with sotorasib and anti PD-1/L1 * Phase 1 monotherapy treatment naïve advanced NSCLC * Phase 2 monotherapy dose comparison

    24 Months

  • Primary: Number of subjects with treatment-related adverse events

    Treatment-related adverse events will be a primary outcome measure for the following groups: * Phase 1 Dose Exploration Part 1 monotherapy * Phase 1 Dose Expansion Part 2 monotherapy * Phase 1 combination arm with sotorasib and anti PD-1/L1 * Phase 1 monotherapy treatment naïve advanced NSCLC

    24 Months

  • Primary: Number of subjects with grade ≥3 treatment-emergent adverse events

    Grade ≥3 treatment-emergent adverse events will be a primary outcome measure in the following group: \- Phase 2 monotherapy dose comparison

    24 Months

  • Primary: Number of subjects with serious adverse events

    Serious adverse events will be a primary outcome measure in the following group: \- Phase 2 monotherapy dose comparison

    24 Months

  • Primary: Number of subjects with adverse events of interest

    Adverse events of interest will be a primary outcome measure in the following group: \- Phase 2 monotherapy dose comparison

    24 Months

  • Primary: Number of subjects with clinically significant changes in vital signs

    Vital signs will be a primary outcome measure for the following groups: * Phase 1 Dose Exploration Part 1 monotherapy * Phase 1 Dose Expansion Part 2 monotherapy * Phase 1 combination arm with sotorasib and anti PD-1/L1 * Phase 1 monotherapy treatment naïve advanced NSCLC

    Baseline to 24 Months

  • Primary: Number of subjects with clinically significant changes in physical examination results

    Physical examinations will be a primary outcome measure for the following groups: * Phase 1 Dose Exploration Part 1 monotherapy * Phase 1 Dose Expansion Part 2 monotherapy * Phase 1 combination arm with sotorasib and anti PD-1/L1

    Baseline to 24 Months

  • Primary: Number of subjects with clinically significant changes on electrocardiograms (ECGs)

    ECGs will be a primary outcome measure for the following groups: * Phase 1 Dose Exploration Part 1 monotherapy * Phase 1 Dose Expansion Part 2 monotherapy * Phase 1 combination arm with sotorasib and anti PD-1/L1 * Phase 1 monotherapy treatment naïve advanced NSCLC

    Baseline to 24 Months

  • Primary: Number of subjects with clinically significant changes in clinical laboratory values

    Abnormal clinical laboratory values will be a primary outcome measure for the following groups: * Phase 1 Dose Exploration Part 1 monotherapy * Phase 1 Dose Expansion Part 2 monotherapy * Phase 1 combination arm with sotorasib and anti PD-1/L1 * Phase 1 monotherapy treatment naïve advanced NSCLC

    Baseline to 24 Months

  • Primary: Number of subjects with dose-limiting toxicities (DLTs)

    DLTs will be a primary outcome measure for the following groups: * Phase 1 Dose Exploration Part 1 monotherapy * Phase 1 Dose Expansion Part 2 monotherapy * Phase 1 combination arm with sotorasib and anti PD-1/L1 * Phase 1 monotherapy treatment naïve advanced NSCLC

    21 Days

  • Primary: Objective response rate (ORR) as assessed by RECIST 1.1 criteria

    ORR will be a primary outcome measure in the following group: * Phase 1 monotherapy treatment naïve advanced NSCLC * Phase 2 monotherapy * Phase 2 monotherapy dose comparison

    24 Months

  • Primary: Duration of response (DOR) as assessed by RECIST 1.1 criteria

    DOR will be a primary outcome measure in the following group: \- Phase 1 monotherapy treatment naïve advanced NSCLC

    24 Months

  • Primary: Disease control as assessed by RECIST 1.1 criteria

    Disease control will be a primary outcome measure in the following group: \- Phase 1 monotherapy treatment naïve advanced NSCLC

    24 Months

  • Primary: Duration of stable disease (SD) as assessed by RECIST 1.1 criteria

    Duration of SD will be a primary outcome measure in the following group: \- Phase 1 monotherapy treatment naïve advanced NSCLC

    24 Months

  • Primary: Time to response (TTR) as assessed by RECIST 1.1 criteria

    TTR will be a primary outcome measure in the following group: \- Phase 1 monotherapy treatment naïve advanced NSCLC

    24 Months

Secondary Outcomes (30)

  • Secondary: Plasma concentration (Cmax) of sotorasib

    15 Weeks

  • Secondary: Plasma concentration (Cmax) of midazolam

    16 Days

  • Secondary: Time to achieve Cmax (Tmax) of sotorasib

    15 Weeks

  • Secondary: Area under the plasma concentration-time curve (AUC) of sotorasib

    15 Weeks

  • Secondary: Area under the plasma concentration-time curve (AUC) of midazolam

    16 Days

  • +25 more secondary outcomes

Study Arms (6)

Phase 1 Dose Exploration Part 1 monotherapy

EXPERIMENTAL

Cohorts with food effect and alternative dosing regimens Enrollment into the dose exploration cohorts may be from any eligible solid tumor type. Dose escalation will begin with 2-4 subjects treated at the lowest planned dose level of 180 mg. If no DLT is observed, dose escalation will continue to the next planned dose cohort

Drug: sotorasib

Phase 1 Dose Expansion Part 2 monotherapy

EXPERIMENTAL

Upon completing the dose exploration part of the study, dose expansion may proceed with 3 groups consisting of subjects with KRAS p.G12C mutant advanced solid tumors. Dose expansion in these 3 groups may be done concurrently

Drug: sotorasib

Phase 1 combination arm with sotorasib and anti PD-1/L1

EXPERIMENTAL

Additional subjects will be enrolled into the combination arm with sotorasib in combination with an anti (PD-1/L1)

Drug: sotorasibDrug: Anti PD-1/L1

Phase 1 monotherapy treatment naive advanced NSCLC

EXPERIMENTAL

Separate cohort of part 1 dose expansion subjects to evaluate the safety and clinical activity of sotorasib administered orally once daily in subjects with previously untreated advanced non-small cell lung cancer (NSCLC). Drug-drug interaction will be evaluated in 6 of the subjects enrolled in the treatment naive cohort by adding Midazolam alone on Day -1 and in combination with sotorasib on Day 15 of Cycle 1, where each cycle is 21 days.

Drug: sotorasibDrug: Midazolam

Phase 2 monotherapy dose comparison

EXPERIMENTAL

Subjects with NSCLC will be enrolled in a dose comparison study evaluating safety and efficacy

Drug: sotorasib

Phase 1 Does escalation and Expansion monotherapy BID

EXPERIMENTAL

BID 2L+solid tumors (fed state)

Drug: sotorasib

Interventions

Administered as an intravenous (IV) infusion

Phase 1 combination arm with sotorasib and anti PD-1/L1

Administered as an oral hydrochloride (HCI) syrup

Phase 1 monotherapy treatment naive advanced NSCLC

Characterize the pharmacokinetics (PK) of sotorasib following administration as an oral Tablet formulation

Phase 1 Does escalation and Expansion monotherapy BIDPhase 1 Dose Expansion Part 2 monotherapyPhase 1 Dose Exploration Part 1 monotherapyPhase 1 combination arm with sotorasib and anti PD-1/L1Phase 1 monotherapy treatment naive advanced NSCLCPhase 2 monotherapy dose comparison

Eligibility Criteria

Age18 Years - 100 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Men or women greater than or equal to 18 years old.
  • Pathologically documented, locally-advanced or metastatic malignancy with, KRAS p.G12C mutation identified through molecular testing.

You may not qualify if:

  • Active brain metastases from non-brain tumors.
  • Myocardial infarction within 6 months of study day 1.
  • Gastrointestinal (GI) tract disease causing the inability to take oral medication.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (133)

City of Hope National Medical Center

Duarte, California, 91010, United States

Location

University of California Los Angeles

Los Angeles, California, 90095, United States

Location

University of California at SF

San Francisco, California, 94115, United States

Location

Sarcoma Oncology Research Center LLC

Santa Monica, California, 90403, United States

Location

Rocky Mountain Cancer Centers

Denver, Colorado, 80218, United States

Location

Sarah Cannon Research Institute at HealthONE

Denver, Colorado, 80218, United States

Location

Smilow Cancer Hospital at Yale New Haven

New Haven, Connecticut, 06510, United States

Location

Medical Oncology Hematology Consultants Helen F Graham Cancer Center

Newark, Delaware, 19713, United States

Location

University of Florida Health

Gainesville, Florida, 32610, United States

Location

AdventHealth Orlando Infusion Center

Orlando, Florida, 32804, United States

Location

Moffitt Cancer Center

Tampa, Florida, 33612, United States

Location

Winship Cancer Institute

Atlanta, Georgia, 30322, United States

Location

Indiana University

Indianapolis, Indiana, 46202, United States

Location

American Oncology Partners of Maryland, PA

Bethesda, Maryland, 20817, United States

Location

Massachusetts General Hospital

Boston, Massachusetts, 02114, United States

Location

Dana Farber Cancer Institute

Boston, Massachusetts, 02215, United States

Location

University of Michigan

Ann Arbor, Michigan, 48109, United States

Location

Henry Ford Health System

Detroit, Michigan, 48202, United States

Location

Washington University

St Louis, Missouri, 63110-1093, United States

Location

Roswell Park Cancer Institute

Buffalo, New York, 14263, United States

Location

Laura and Isaac Perlmutter Cancer Center at New York University Langone

New York, New York, 10016, United States

Location

Memorial Sloan Kettering Cancer Center

New York, New York, 10065, United States

Location

Duke University Medical Center, Morris Cancer Clinic

Durham, North Carolina, 27710, United States

Location

University Hospitals Cleveland Medical Center

Cleveland, Ohio, 44106, United States

Location

Cleveland Clinic

Cleveland, Ohio, 44195, United States

Location

University of Pennsylvania

Philadelphia, Pennsylvania, 19104, United States

Location

Fox Chase Cancer Center

Philadelphia, Pennsylvania, 19111, United States

Location

University of Pittsburgh Medical Center Cancer Pavillion

Pittsburgh, Pennsylvania, 15232, United States

Location

Gibbs Cancer Center and Research Institute - Spartanburg

Spartanburg, South Carolina, 29303, United States

Location

Vanderbilt University Ingram Cancer Center

Nashville, Tennessee, 37232, United States

Location

Texas Oncology - Austin Central

Austin, Texas, 78731, United States

Location

Texas Oncology - Baylor

Dallas, Texas, 75246, United States

Location

University of Texas Southwestern Medical Center

Dallas, Texas, 75390, United States

Location

University of Texas MD Anderson Cancer Center

Houston, Texas, 77030, United States

Location

Huntsman Cancer Institute

Salt Lake City, Utah, 84112, United States

Location

US Oncology Research Investigational Products Center

Fairfax, Virginia, 22031, United States

Location

Virginia Cancer Specialists PC

Fairfax, Virginia, 22031, United States

Location

Blue Ridge Cancer Care

Salem, Virginia, 24153, United States

Location

Seattle Cancer Care Alliance

Seattle, Washington, 98109, United States

Location

Scientia Clinical Research Ltd

Randwick, New South Wales, 2031, Australia

Location

Princess Alexandra Hospital

Woolloongabba, Queensland, 4102, Australia

Location

The Queen Elizabeth Hospital

Woodville South, South Australia, 5011, Australia

Location

Peter MacCallum Cancer Centre

Parkville, Victoria, 3050, Australia

Location

Medizinische Universitaet Graz

Graz, 8036, Austria

Location

Medizinische Universitaet Innsbruck

Innsbruck, 6020, Austria

Location

Universitaetsklinikum Krems

Krems, 3500, Austria

Location

Universitaetsklinikum Allgemeines Krankenhaus Wien

Vienna, 1090, Austria

Location

Krankenhaus Nord - Klinik Floridsdorf

Vienna, 1210, Austria

Location

Institut Jules Bordet

Brussels, B-1070, Belgium

Location

Grand Hopital de Charleroi

Charleroi, 6000, Belgium

Location

Universitair Ziekenhuis Antwerpen

Edegem, 2650, Belgium

Location

Ziekenhuis Oost-Limburg

Genk, 3600, Belgium

Location

Universitair Ziekenhuis Gent

Ghent, 9000, Belgium

Location

Jessa Ziekenhuis - Campus Virga Jesse

Hasselt, 3500, Belgium

Location

Universitair Ziekenhuis Leuven - Campus Gasthuisberg

Leuven, 3000, Belgium

Location

Centre Hospitalier Universitaire de Liege

Liège, 4000, Belgium

Location

AZ Delta Campus Rumbeke

Roeselare, 8800, Belgium

Location

Irmandade da Santa Casa de Misericordia de Porto Alegre, Nucleo de Novos Tratamentos em Cancer

Porto Alegre, Rio Grande do Sul, 90050-170, Brazil

Location

Hospital Sao Lucas da Pontificia Universidade Catolica do Rio Grande do Sul

Porto Alegre, Rio Grande do Sul, 90610-000, Brazil

Location

Hospital de Base de Sao Jose do Rio Preto

São José do Rio Preto, São Paulo, 15090-000, Brazil

Location

Sociedade Beneficente de Senhoras Hospital Sirio Libanes

São Paulo, São Paulo, 01308-050, Brazil

Location

Oncologia Rede D´Or

São Paulo, São Paulo, 04501-000, Brazil

Location

Instituto Coi

Rio de Janeiro, 20231-050, Brazil

Location

Tom Baker Cancer Centre

Calgary, Alberta, T2N 4N2, Canada

Location

Cross Cancer Institute

Edmonton, Alberta, T6G 1Z2, Canada

Location

London Regional Cancer Program, London Health Sciences Centre

London, Ontario, N6A 5W9, Canada

Location

The Ottawa Hospital Cancer Centre

Ottawa, Ontario, K1H 8L6, Canada

Location

Princess Margaret Cancer Centre

Toronto, Ontario, M5G 2M9, Canada

Location

McGill University Health Centre Glen Site

Montreal, Quebec, H4A 3J1, Canada

Location

Institut Bergonie

Bordeaux, 33076, France

Location

Centre Hospitalier Intercommunal de Créteil

Créteil, 94010, France

Location

Hopital de la Timone

Marseille, 13385, France

Location

Institut Curie

Paris, 75005, France

Location

Institut Claudius Regaud

Toulouse, 31059, France

Location

Gustave Roussy

Villejuif, 94805, France

Location

Universitatsklinikum Koln

Cologne, 50937, Germany

Location

Universitätsklinikum Essen

Essen, 45147, Germany

Location

Klinikum der Universität München Campus Grosshadern

München, 81377, Germany

Location

Henry Dunant Hospital Center

Athens, 11526, Greece

Location

Metropolitan Hospital

Athens, 18547, Greece

Location

University Hospital of Heraklion

Heraklion - Crete, 71500, Greece

Location

Theagenion Cancer Hospital

Thessaloniki, 54007, Greece

Location

Agios Loukas Clinic

Thessaloniki, 55236, Greece

Location

Semmelweis Egyetem

Budapest, 1083, Hungary

Location

Orszagos Koranyi Pulmonologiai Intezet

Budapest, 1121, Hungary

Location

Somogy Megyei Kaposi Mor Oktato Korhaz

Kaposvár, 7400, Hungary

Location

Fejer Megyei Szent Gyorgy Egyetemi Oktato Korhaz

Székesfehérvár, 8000, Hungary

Location

Szent Borbala Korhaz

Tatabánya, 2800, Hungary

Location

Tudogyogyintezet Torokbalint

Törökbálint, 2045, Hungary

Location

Aichi Cancer Center

Nagoya, Aichi-ken, 464-8681, Japan

Location

National Cancer Center Hospital East

Kashiwa-shi, Chiba, 277-8577, Japan

Location

National Hospital Organization Shikoku Cancer Center

Matsuyama, Ehime, 791-0280, Japan

Location

National Hospital Organization Kyushu Cancer Center

Fukuoka, Fukuoka, 811-1395, Japan

Location

National Hospital Organization Hokkaido Cancer Center

Sapporo, Hokkaido, 003-0804, Japan

Location

St Marianna University Hospital

Kawasaki-shi, Kanagawa, 216-8511, Japan

Location

Kanagawa Prefectural Hospital Organization Kanagawa Cancer Center

Yokohama, Kanagawa, 241-8515, Japan

Location

Sendai Kousei Hospital

Sendai, Miyagi, 980-0873, Japan

Location

Niigata Cancer Center Hospital

Niigata, Niigata, 951-8566, Japan

Location

Okayama University Hospital

Okayama, Okayama-ken, 700-8558, Japan

Location

Kansai Medical University Hospital

Hirakata-shi, Osaka, 573-1191, Japan

Location

Osaka International Cancer Institute

Osaka, Osaka, 541-8567, Japan

Location

Shizuoka Cancer Center

Sunto-gun, Shizuoka, 411-8777, Japan

Location

The Cancer Institute Hospital of Japanese Foundation for Cancer Research

Koto-ku, Tokyo, 135-8550, Japan

Location

Wakayama Medical University Hospital

Wakayama, Wakayama, 641-8510, Japan

Location

Fundacao Champalimaud

Lisbon, 1400-038, Portugal

Location

Centro Hospitalar Universitario de Lisboa Norte EPE - Hospital Pulido Valente

Lisbon, 1769-001, Portugal

Location

Unidade Local de Saude de Matosinhos, EPE - Hospital Pedro Hispano

Matosinhos Municipality, 4464-513, Portugal

Location

Centro Hospitalar Universitario do Porto EPE - Hospital de Santo Antonio

Porto, 4099-001, Portugal

Location

Hospital Cuf porto

Porto, 4100-180, Portugal

Location

Institutul Oncologic, Prof Dr Alexandru Trestioreanu

Bucharest, 022328, Romania

Location

Institutul Oncologic Prof Dr Ion Chiricuta Cluj-Napoca

Cluj-Napoca, 400015, Romania

Location

SC Medisprof SRL

Cluj-Napoca, 400641, Romania

Location

Centrul de Radioterapie Amethyst Cluj

Cluj-Napoca, 407280, Romania

Location

Centrul de Oncologie Sf Nectarie SRL

Craiova, 200347, Romania

Location

Institutul Regional de Oncologie Iasi

Iași, 700483, Romania

Location

Spitalul Municipal Ploiesti

Ploieşti, 100337, Romania

Location

SC Oncomed SRL

Timișoara, 300239, Romania

Location

National Cancer Center

Goyang-si Gyeonggi-do, 10408, South Korea

Location

Seoul National University Bundang Hospital

Seongnam-si, Gyeonggi-do, 13620, South Korea

Location

Seoul National University Hospital

Seoul, 03080, South Korea

Location

Severance Hospital Yonsei University Health System

Seoul, 03722, South Korea

Location

Asan Medical Center

Seoul, 05505, South Korea

Location

Samsung Medical Center

Seoul, 06351, South Korea

Location

The Catholic University of Korea Seoul St Marys Hospital

Seoul, 06591, South Korea

Location

Hospital Universitari Germans Trias i Pujol

Badalona, Catalonia, 08916, Spain

Location

Hospital General Universitario de Valencia

Valencia, Valencia, 46014, Spain

Location

Hospital General Universitario Gregorio Marañon

Madrid, 28009, Spain

Location

Clinica Universidad de Navarra

Madrid, 28027, Spain

Location

Fundacion Jimenez Diaz

Madrid, 28040, Spain

Location

Hospital Universitario Madrid Sanchinarro

Madrid, 28050, Spain

Location

Universitaetsspital Basel

Basel, 4031, Switzerland

Location

Hopitaux Universitaires de Geneve

Geneva, 1211, Switzerland

Location

Universitaetsspital Zuerich

Zurich, 8091, Switzerland

Location

Related Publications (12)

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  • Dy GK, Govindan R, Velcheti V, Falchook GS, Italiano A, Wolf J, Sacher AG, Takahashi T, Ramalingam SS, Dooms C, Kim DW, Addeo A, Desai J, Schuler M, Tomasini P, Hong DS, Lito P, Tran Q, Jones S, Anderson A, Hindoyan A, Snyder W, Skoulidis F, Li BT. Long-Term Outcomes and Molecular Correlates of Sotorasib Efficacy in Patients With Pretreated KRAS G12C-Mutated Non-Small-Cell Lung Cancer: 2-Year Analysis of CodeBreaK 100. J Clin Oncol. 2023 Jun 20;41(18):3311-3317. doi: 10.1200/JCO.22.02524. Epub 2023 Apr 25.

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    PMID: 38975874BACKGROUND
  • Hochmair MJ, Vermaelen K, Mountzios G, Carcereny E, Dooms C, Lee SH, Morocz E, Kato T, Ciuleanu TE, Dy GK, Parente B, O'Byrne KJ, Chu QS, Castro Junior G, Girard N, Snyder W, Tran Q, Kormany W, Houk B, Mehta B, Curioni-Fontecedro A. Sotorasib (960 mg or 240 mg) once daily in patients with previously treated KRAS G12C-mutated advanced NSCLC. Eur J Cancer. 2024 Sep;208:114204. doi: 10.1016/j.ejca.2024.114204. Epub 2024 Jul 5.

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  • Nagase M, Houk B, Vuu I, Cardona P, Dutta S, Lin CW. Population Pharmacokinetics of Sotorasib in Healthy Subjects and Advanced Solid Tumor Patients Harboring a KRASG12C Mutation from Phase 1 and Phase 2 Studies. AAPS J. 2025 Jan 13;27(1):26. doi: 10.1208/s12248-024-01013-6.

    PMID: 39806205BACKGROUND
  • Strickler JH, Satake H, George TJ, Yaeger R, Hollebecque A, Garrido-Laguna I, Schuler M, Burns TF, Coveler AL, Falchook GS, Vincent M, Sunakawa Y, Dahan L, Bajor D, Rha SY, Lemech C, Juric D, Rehn M, Ngarmchamnanrith G, Jafarinasabian P, Tran Q, Hong DS. Sotorasib in KRAS p.G12C-Mutated Advanced Pancreatic Cancer. N Engl J Med. 2023 Jan 5;388(1):33-43. doi: 10.1056/NEJMoa2208470. Epub 2022 Dec 21.

  • Lanman BA, Allen JR, Allen JG, Amegadzie AK, Ashton KS, Booker SK, Chen JJ, Chen N, Frohn MJ, Goodman G, Kopecky DJ, Liu L, Lopez P, Low JD, Ma V, Minatti AE, Nguyen TT, Nishimura N, Pickrell AJ, Reed AB, Shin Y, Siegmund AC, Tamayo NA, Tegley CM, Walton MC, Wang HL, Wurz RP, Xue M, Yang KC, Achanta P, Bartberger MD, Canon J, Hollis LS, McCarter JD, Mohr C, Rex K, Saiki AY, San Miguel T, Volak LP, Wang KH, Whittington DA, Zech SG, Lipford JR, Cee VJ. Discovery of a Covalent Inhibitor of KRASG12C (AMG 510) for the Treatment of Solid Tumors. J Med Chem. 2020 Jan 9;63(1):52-65. doi: 10.1021/acs.jmedchem.9b01180. Epub 2019 Dec 24.

Related Links

MeSH Terms

Interventions

sotorasibMidazolam

Intervention Hierarchy (Ancestors)

BenzodiazepinesBenzazepinesHeterocyclic Compounds, 2-RingHeterocyclic Compounds, Fused-RingHeterocyclic Compounds

Study Officials

  • MD

    Amgen

    STUDY DIRECTOR

Study Design

Study Type
interventional
Phase
phase 1
Allocation
RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
SEQUENTIAL
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR
Expanded Access
Yes

Study Record Dates

First Submitted

June 26, 2018

First Posted

July 26, 2018

Study Start

August 27, 2018

Primary Completion

May 29, 2026

Study Completion

May 29, 2026

Last Updated

June 30, 2026

Record last verified: 2026-06

Data Sharing

IPD Sharing
Will share

De-identified individual patient data for variables necessary to address the specific research question in an approved data sharing request

Shared Documents
STUDY PROTOCOL, SAP, ICF, CSR
Time Frame
Data sharing requests relating to this study will be considered beginning 18 months after the study has ended and either 1) the product and indication have been granted marketing authorization in both the US and Europe or 2) clinical development for the product and/or indication discontinues and the data will not be submitted to regulatory authorities. There is no end date for eligibility to submit a data sharing request for this study.
Access Criteria
Qualified researchers may submit a request containing the research objectives, the Amgen product(s) and Amgen study/studies in scope, endpoints/outcomes of interest, statistical analysis plan, data requirements, publication plan, and qualifications of the researcher(s). In general, Amgen does not grant external requests for individual patient data for the purpose of re-evaluating safety and efficacy issues already addressed in the product labelling. Requests are reviewed by a committee of internal advisors. If not approved, a Data Sharing Independent Review Panel will arbitrate and make the final decision. Upon approval, information necessary to address the research question will be provided under the terms of a data sharing agreement. This may include anonymized individual patient data and/or available supporting documents, containing fragments of analysis code where provided in analysis specifications. Further details are available at the URL below.
More information

Locations