Success Metrics

Clinical Success Rate
78.6%

Based on 11 completed trials

Completion Rate
79%(11/14)
Active Trials
22(50%)
Results Posted
64%(7 trials)
Terminated
3(7%)

Phase Distribution

Ph phase_1
22
50%
Ph phase_3
4
9%
Ph early_phase_1
1
2%
Ph phase_2
15
34%

Phase Distribution

23

Early Stage

15

Mid Stage

4

Late Stage

Phase Distribution42 total trials
Early Phase 1First-in-human
1(2.4%)
Phase 1Safety & dosage
22(52.4%)
Phase 2Efficacy & side effects
15(35.7%)
Phase 3Large-scale testing
4(9.5%)

Highest Phase Reached

Phase 3

Trial Status & Enrollment

Completion Rate

61.1%

11 of 18 finished

Non-Completion Rate

38.9%

7 ended early

Currently Active

22

trials recruiting

Total Trials

44

all time

Status Distribution
Active(25)
Completed(11)
Terminated(7)
Other(1)

Detailed Status

Recruiting17
Completed11
Active, not recruiting5
Withdrawn4
Not yet recruiting3
Terminated3

Development Timeline

Analytics

Development Status

Total Trials
44
Active
22
Success Rate
78.6%
Most Advanced
Phase 3

Trials by Phase

Early Phase 11 (2.4%)
Phase 122 (52.4%)
Phase 215 (35.7%)
Phase 34 (9.5%)

Trials by Status

recruiting1739%
not_yet_recruiting37%
completed1125%
terminated37%
active_not_recruiting511%
unknown12%
withdrawn49%

Recent Activity

Clinical Trials (44)

Showing 20 of 44 trialsScroll for more
NCT05638295Phase 2

Testing the Use of AMG 510 (Sotorasib) and Panitumumab as a Targeted Treatment for KRAS G12C Mutant Solid Tumor Cancers (A ComboMATCH Treatment Trial)

Active Not Recruiting
NCT05564377Phase 2

Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial

Recruiting
NCT07563738Phase 1

A 2-part Phase 1/2 Open-label Trial on ODM-212

Recruiting
NCT05920356Phase 3

A Study Evaluating Sotorasib Platinum Doublet Combination Versus Pembrolizumab Platinum Doublet Combination as a Front-Line Therapy in Participants With Stage IV or Advanced Stage IIIB/C Nonsquamous Non-Small Cell Lung Cancers (CodeBreaK 202)

Recruiting
NCT05398094Phase 2

Clinical Trial of AMG510 in Stage III Unresectable NSCLC KRAS p.G12C Patients and Ineligible for Chemo-radiotherapy

Recruiting
NCT05198934Phase 3

Sotorasib and Panitumumab Versus Investigator's Choice for Participants With Kirsten Rat Sarcoma (KRAS) p.G12C Mutation

Completed
NCT06252649Phase 3

Study of Sotorasib, Panitumumab and FOLFIRI Versus FOLFIRI With or Without Bevacizumab-awwb in Treatment-naïve Participants With Metastatic Colorectal Cancer With KRAS p.G12C Mutation

Recruiting
NCT07543172Phase 2

CIMAvax-EGF With KRAS G12C Inhibitor for the Treatment of Advanced, KRAS G12C Mutated Non Small Cell Lung Cancer

Not Yet Recruiting
NCT06497556Phase 3

A Study Evaluating the Efficacy and Safety of Divarasib Versus Sotorasib or Adagrasib in Participants With Previously Treated KRAS G12C-positive Advanced or Metastatic Non-Small Cell Lung Cancer

Active Not Recruiting
NCT06333951Phase 1

Anvumetostat Alone or in Combination With Other Therapies in Subjects With Advanced Thoracic Tumors With Homozygous MTAP-deletion (Master Protocol) (MTAPESTRY 104).

Recruiting
NCT07012031Phase 1

Sotorasib in Combination With Trastuzumab Deruxtecan for the Treatment of Locally Advanced and Metastatic Non-small Cell Lung Cancer With a KRAS G12C Mutation

Recruiting
NCT07172919Phase 2

A Rollover Study Evaluating Sotorasib With or Without Panitumumab in Participants With KRAS p.G12C Mutation

Recruiting
NCT04892017Phase 1

Study of Inlexisertib (DCC-3116) in Participants With RAS/MAPK Pathway Mutant Solid Tumors

Terminated
NCT06582771Phase 2

A Study of Sotorasib in People With Non-Small Cell Lung Cancer

Recruiting
NCT06804824Phase 1

A First-in-Human (FIH) Study to Evaluate the Safety and Tolerability of VVD-159642 in Participants With Advanced Solid Tumors

Recruiting
NCT03600883Phase 1

A Phase 1/2, Study Evaluating the Safety, Tolerability, PK, and Efficacy of Sotorasib (AMG 510) in Subjects With Solid Tumors With a Specific KRAS Mutation (CodeBreaK 100)

Active Not Recruiting
NCT05845450Phase 2

Pre-operative Targeted Treatments in Molecularly Selected Resectable Colorectal Cancer (UNICORN)

Recruiting
NCT07318389Early Phase 1

ASCEND-CRC: Profiling and Targeting Dynamic Tumor Resistance in Patients With Metastatic Colorectal Cancer

Not Yet Recruiting
NCT06333678Phase 2

A Study Comparing Sotorasib With Durvalumab in People With Non-Small Cell Lung Cancer (NSCLC)

Completed
NCT05054725Phase 2

Combination Study of RMC-4630 and Sotorasib for NSCLC Subjects With KRASG12C Mutation After Failure of Prior Standard Therapies

Completed

Drug Details

Intervention Type
DRUG
Total Trials
44