Influence of Mango Intake of Skin Health in Postmenopausal Women

NCT03590756 | Completed

• 1 other identifier: 1185928
• Study Type: interventional
• Target: 36
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to investigate the effects on 16 weeks of mango intake on skin health in postmenopausal women. Half of the participants will receive 85g portions of mangoes while the other half receive 250g portions of mangos. Participants will be instructed to consume the specific portion 4 times a week, for a total duration of 16 weeks.

Conditions

Wrinkle; Skin Red

Keywords

Skin Health; Skin Wrinkle; Skin Redness; Carotenoid; Mango

Outcome Measures

Primary Outcomes (2)

• Skin Wrinkle Depth and Redness

  Using a skin camera from BrighTex Bio-Photonics to measure change in skin wrinkle depth and redness within a period of 16 weeks.

  0, 8, and 16 week

• Skin carotenoid

  Using a skin photometer (Veggie Meter) to measure change in skin carotenoid within a period of 16 weeks.

  0, 4, 8, 12, and 16 weeks

Secondary Outcomes (2)

• Sebum

  0, 8, 16, weeks

• Plasma carotenoid

  0, 8, 16 weeks.

Study Arms (2)

High mango group

EXPERIMENTAL

250g (1.5 cup) of mango intake per day, 4 days a week for 16 weeks

Other: 16 weeks mango intake

Low mango group

OTHER

85g (0.5 cup) of mango intake per day, 4 days a week for 16 weeks

Other: 16 weeks mango intake

Interventions

16 weeks mango intake OTHER

Participants will be provided fresh frozen Ataulfo mangoes.

High mango group; Low mango group

Eligibility Criteria

• Age: 50 Years - 70 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Postmenopausal
• Fitzpatrick skin type I and II
• BMI 18.5 - 35.0 kg/m2
• Normal blood levels in the comprehensive metabolic panel, or values slightly out of range as approved by the study physician

You may not qualify if:

• Allergic to mangoes
• Fruit consumption of 2 or more cups per day
• Vegetable consumption of 3 or more cups per day for females
• Fruit juice consumption of more than 1 cup per day
• Self-reported malabsorption
• Currently taking regular prescription drugs i.e. statins, thyroid, anti-inflammatory drugs
• Had any medical or cosmetic procedures such as laser resurfacing or plastic surgery to the face within the last 6 months, including botulinum toxin, dermal fillers, collagen or other similar cosmetic procedure
• Autoimmune photosensitive condition or known genetic condition with a deficiency in collagen production (such as Ehler-Danlos)
• Smoking (current smoker, smoked within the past year, former smokers with greater than a 20 pack-year history of smoking within the past 20 years.
• Indications of substance or alcohol abuse
• Unwillingness to discontinue high antioxidant supplements during washout and interventions

Sponsors & Collaborators

• University of California, Davis: lead
• National Mango Board: collaborator

Study Sites (1)

Ragle Human Nutrition Research Center

Davis, California, 95616, United States

Location

MeSH Terms

Conditions

Erythema

Condition Hierarchy (Ancestors)

Skin Diseases; Skin and Connective Tissue Diseases; Skin Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 3, 2018
• First Posted: July 18, 2018
• Study Start: July 17, 2018
• Primary Completion: May 31, 2019
• Study Completion: May 31, 2019
• Last Updated: October 14, 2019

Record last verified: 2019-10

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)