Effect of Intravenous Metoprolol Combining RIC on Myocardial Protection in STEMI Patients
Combined Metoprolol and Remote Ischemic Conditioning in Cardioprotection of Anterior ST-segment Elevation Myocardial Infarction (METRICATION)
1 other identifier
interventional
1,206
1 country
16
Brief Summary
The main purpose of this study is to compare the myocardial protection effect of intravenous metoprolol combined with remote ischemic conditioning (RIC) and single treatment before reperfusion in Chinese patients with anterior STEMI. This study sought to find possible strategies to further improve myocardial protection in Chinese patients with anterior STEMI.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable
Started Nov 2017
Longer than P75 for not_applicable
16 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
November 28, 2017
CompletedFirst Submitted
Initial submission to the registry
May 17, 2018
CompletedFirst Posted
Study publicly available on registry
July 9, 2018
CompletedPrimary Completion
Last participant's last visit for primary outcome
August 31, 2020
CompletedStudy Completion
Last participant's last visit for all outcomes
August 30, 2021
CompletedNovember 4, 2021
October 1, 2021
2.8 years
May 17, 2018
October 27, 2021
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Myocardial infarct size
Estimating myocardial infarct size by area under CK, CK-MB curve
60 hours
Secondary Outcomes (4)
Major adverse cardiac and cerebrovascular events (MACCE)
1 year
Incidence of heart failure
1 year
myocardial infarct size measured by MRI (optional)
7 days after AMI
Safety endpoint: incidence of severe bradycardia or hypotension
24 hours
Study Arms (4)
Placebo group
PLACEBO COMPARATORPatients receive intravenous placebo injection.
Intravenous metoprolol group
EXPERIMENTALPatients receive intravenous metoprolol injection.
RIC group
EXPERIMENTALPatients receive RIC treatment.
Intravenous metoprolol and RIC group
EXPERIMENTALPatients receive intravenous metoprolol injection and RIC treatment.
Interventions
Patients receive intravenous Metoprolol injection
Patients receive Metoprolol \& RIC treatment
Eligibility Criteria
You may qualify if:
- ages 18 to 80 years;
- presenting within 12 h of symptoms onset, with anterior STEMI and planned for pPCI; anterior STEMI was defined as the occurrence of \>20 min of chest pain and ST-segment elevation (\>2 mm) in at least 2 contiguous precordial leads;
- sign informed consent;
You may not qualify if:
- systolic blood pressure \< 110mmHg;
- cardiogenic shock or with heart failure symptoms, Killip III\~IV;
- allergic history of metoprolol;
- history of asthma or the need for bronchodilators;
- PR interval \> 240ms, II\~III atrioventricular block；
- heart rate \< 60 beats/min;
- unable to consent;
- pregnancy and lactation women;
- life expectancy for diseases (i.e. cancer) \< 1 year.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Harbin Medical Universitylead
- Beijing Chao Yang Hospitalcollaborator
Study Sites (16)
Peking Univerisity People'Hospital
Beijing, Beijing Municipality, 100044, China
Beijing Chao-Yang Hospital, Capital Medical University
Beijing, Beijing Municipality, China
Guangdong general hospital
Guangzhou, Guangdong, China
Second hospital of hebei medical university
Shijiazhuang, Hebei, China
Daqing Oilfield General Hospital
Daqing, Heilongjiang, 163001, China
The first affiliated hospital of Zhengzhou medical university
Zhengzhou, Henan, China
Zhongda Hospital Southeast University
Nanjing, Jiangsu, 210009, China
The Second Affiliated Hospital of Nanchang University
Nanchang, Jiangxi, 330006, China
The Second Hospital of Jilin University
Changchun, Jilin, 130000, China
the second affiliated hospital of Dalian medical university
Dalian, Liaoning, China
Shenyang military district general hospital of the people's liberation army
Shenyang, Liaoning, China
The first affiliated hospital of military medical university
Xi’an, Shanxi, China
Third Military Medical University
Chongqing, Sichuan, China
The General Hospital of Tianjin Medical University
Tianjin, Tianjin Municipality, China
Tianjin Chest Hospital
Tianjin, Tianjin Municipality, China
The First Affiliated Hospital of Xinjiang Medical University
Ürümqi, Xinjiang, China
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- TREATMENT
- Intervention Model
- FACTORIAL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- director
Study Record Dates
First Submitted
May 17, 2018
First Posted
July 9, 2018
Study Start
November 28, 2017
Primary Completion
August 31, 2020
Study Completion
August 30, 2021
Last Updated
November 4, 2021
Record last verified: 2021-10