The Effect of Vinegar Consumption on Visceral Fat and Blood Glucose Concentration

NCT03577834 | Completed

• 1 other identifier: vinegar_visceral_fat
• Study Type: interventional
• Target: 102
• Locations: 0 countries
• Sites: N/A

Brief Summary

The purpose of this study is to test the potential ability of vinegar to significantly decrease visceral fat in healthy adults with "central obesity". During the 8-week trial, participants will either consume a low-dose vinegar pill (control treatment) or a vinegar drink twice per day. Research Aim and Hypothesis H1 Daily vinegar consumption will be associated with loss in visceral fat (as measured by DXA) after 8 weeks compared to the placebo treatment (low-vinegar pill) in a group of healthy adults with "central obesity". H2 Daily vinegar consumption will be associated with a decrease in abdominal circumference after 8 weeks compared to the placebo treatment (low-vinegar pill) in a group of healthy adults with "central obesity".

Conditions

Visceral Obesity; Tooth Erosion; Insulin Resistance

Keywords

randomized clinical trial; vinegar; adiposity; insulin resistance

Outcome Measures

Primary Outcomes (1)

• visceral adiposity

  visceral fat as measured by DXA

  change after 8 weeks of treatment

Secondary Outcomes (2)

• tooth erosion

  change after 8 weeks of treatment

• insulin resistance

  change after 8 weeks of treatment

Study Arms (2)

Liquid vinegar

EXPERIMENTAL

Participants in this arm were instructed to drink 2 tablespoons of red wine vinegar (provided) mixed with water twice each day for weeks 1 to 8 of the trial.

Dietary Supplement: liquid vinegar

Vinegar pill

PLACEBO COMPARATOR

Participants in the control group were instructed to take one vinegar pill (provided) each day for weeks 1-8 of the trial.

Dietary Supplement: vinegar pill

Interventions

liquid vinegar DIETARY_SUPPLEMENT

6% red wine vinegar (2 tablespoons providing 1.7 g acetic acid)

Also known as: VIN

Liquid vinegar

vinegar pill DIETARY_SUPPLEMENT

Apple Cider Vinegar Tablets (1 tablet providing 0.0225 g acetic acid)

Also known as: CON

Vinegar pill

Eligibility Criteria

• Age: 18 Years - 45 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Nonsmoking
• Not pregnant or lactating if female
• No active disease state or medication use affecting blood glucose or cholesterol (additionally, individuals on digoxin or diuretics will be excluded but other medications in use \>3 months will be allowed)
• No food restrictions or special diet
• BMI range: 22-35
• Waist circumference \>34 (women) and \>39 (males)
• Sedentary (exercising \< 3 days/week)

You may not qualify if:

• Unwilling to take a vinegar supplement daily for 8 week or follow other aspects of study protocol
• Recent abdominal surgery or condition causing abdominal discomfort/distention (such as acid reflux, ascites, pancreatitis, diverticulitis/diverticulosis, Crohn's disease, and/or irritable bowel syndrome)

Sponsors & Collaborators

• Carol Johnston: lead

Related Publications (1)

• Anderson S, Gonzalez LA, Jasbi P, Johnston CS. Evidence That Daily Vinegar Ingestion May Contribute to Erosive Tooth Wear in Adults. J Med Food. 2021 Aug;24(8):894-896. doi: 10.1089/jmf.2020.0108. Epub 2020 Dec 9.

  PMID: 33297831 DERIVED

MeSH Terms

Conditions

Obesity, Abdominal; Tooth Erosion; Insulin Resistance; Obesity

Interventions

Acetic Acid

Condition Hierarchy (Ancestors)

Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Tooth Demineralization; Tooth Diseases; Stomatognathic Diseases; Tooth Wear; Hyperinsulinism; Glucose Metabolism Disorders; Metabolic Diseases

Intervention Hierarchy (Ancestors)

Acetates; Acids, Acyclic; Carboxylic Acids; Organic Chemicals; Fatty Acids, Volatile; Fatty Acids; Lipids

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Masking Details: All participants will receive 'vinegar' either in liquid form (active) or pill (not active as acetic acid concentration is below threshold of effect). Investigators measuring outcome variables (visceral fat, tooth enamel, and blood indices) are blinded to treatment assignment.
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Professor and Associated Director

Model Details: Qualifying participants will be stratified by gender, age, weight, and waist circumference, then randomized into two groups: the intervention group, vinegar drinks (VIN) or the control group, vinegar pills (CON).

Study Record Dates

• First Submitted: June 25, 2018
• First Posted: July 5, 2018
• Study Start: January 5, 2017
• Primary Completion: August 15, 2018
• Study Completion: August 15, 2018
• Last Updated: August 28, 2019

Record last verified: 2019-08