Impact of Inulin on Production of Phenolic Acids From Tomato Onion and Lovage Soup

NCT03577145 | Completed DMC

• 1 other identifier: BB/MO27724/1-2
• Study Type: interventional
• Target: 15
• Locations: 1 country
• Sites: 1

Brief Summary

This is an acute human bioavailability study in self-reported healthy participants aged 20-70 years old. The investigators hypothesize that combination of polyphenolics from a soup rich in rutin and quercitin and the non-digestible carbohydrate (NDC) inulin will increase the production of phenolic acids by bacteria in the human colon and these will be detected in urine. Participants will attend for three arms in a randomized order: Tomato, onion and lovage soup (high polyphenol food), Inulin (NDC) or Mixture of tomato, onion and lovage soup and inulin. During each feeding study, urine, blood and stool samples will be collected at regular intervals for the duration of 24 hrs after consumption of test food. Participants will be asked to follow a low polyphenol diet for 2 days prior to the feeding study.

Conditions

Healthy Adults

Keywords

Bioavailability; Polyphenols; Dietary fibre; Phenolic acids

Outcome Measures

Primary Outcomes (1)

• Phenolic acids bioavailability

  Urine excretion of phenolic acids (µg) will be measured with GC-MS

  0-24 hrs

Secondary Outcomes (4)

• Glycaemic measurements

  0-8 hrs

• Appetite hormones measurements

  0-8 hrs

• Mouth to caecum transit time

  0-8 hrs

• Gastric emptying time

  0-6 hrs

Study Arms (3)

Tomato, onion & lovage soup with inulin

EXPERIMENTAL

One dose of tomato (300g), onion (100g) \& lovage (20g) with 10g inulin will be given to subjects in the form of a soup

Dietary Supplement: Tomato, onion & lovage soup with inulin

Tomato, onion & lovage soup

EXPERIMENTAL

One dose of tomato (300g), onion (100g) \& lovage (20g) will be given to subjects in the form of a soup

Dietary Supplement: Tomato, onion & lovage soup

Inulin

EXPERIMENTAL

One dose of 10g inulin will be given to subjects in the form of a drink

Dietary Supplement: Inulin

Interventions

Tomato, onion & lovage soup with inulin DIETARY_SUPPLEMENT

Source of polyphenols and non digestible carbohydrate

Tomato, onion & lovage soup with inulin

Tomato, onion & lovage soup DIETARY_SUPPLEMENT

Source of polyphenols

Tomato, onion & lovage soup

Inulin DIETARY_SUPPLEMENT

Source of non digestible carbohydrate

Inulin

Eligibility Criteria

• Age: 20 Years - 70 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Self-reported healthy adults

You may not qualify if:

• Antibiotic use within the last 3 months
• Identified gastro-intestinal diseases
• On prescribed medication other than the contraceptive pill
• Pregnant or breastfeeding.
• Diagnosed as anaemic
• Allergic to paracetamol or any food

Sponsors & Collaborators

• University of Glasgow: lead
• Scottish Universities Environmental Research Centre: collaborator

Study Sites (1)

School of Medicine, Nursing and Dentistry, College of MVLS, University of Glasgow

Glasgow, Lanarkshire, G31 2ER, United Kingdom

Location

Related Publications (3)

• Russell W, Duthie G. Plant secondary metabolites and gut health: the case for phenolic acids. Proc Nutr Soc. 2011 Aug;70(3):389-96. doi: 10.1017/S0029665111000152.

  PMID: 21781364 BACKGROUND

• Roowi S, Mullen W, Edwards CA, Crozier A. Yoghurt impacts on the excretion of phenolic acids derived from colonic breakdown of orange juice flavanones in humans. Mol Nutr Food Res. 2009 May;53 Suppl 1:S68-75. doi: 10.1002/mnfr.200800287.

  PMID: 19415668 BACKGROUND

• Tamura M, Nakagawa H, Tsushida T, Hirayama K, Itoh K. Effect of pectin enhancement on plasma quercetin and fecal flora in rutin-supplemented mice. J Food Sci. 2007 Nov;72(9):S648-51. doi: 10.1111/j.1750-3841.2007.00557.x.

  PMID: 18034749 BACKGROUND

MeSH Terms

Interventions

Inulin

Intervention Hierarchy (Ancestors)

Starch; Glucans; Biopolymers; Polymers; Macromolecular Substances; Dietary Carbohydrates; Carbohydrates; Fructans; Polysaccharides

Study Officials

• Christine Edwards, PhD

  University of Glasgow

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Model Details: Acute human bioavailability studies with a cross-over design. Subjects will be given a soup or drink in one of three combinations 1. Tomato onion and lovage soup 2. Inulin 3. Mixture of tomato onion and lovage soup with inulin

Study Record Dates

• First Submitted: December 19, 2017
• First Posted: July 5, 2018
• Study Start: July 27, 2017
• Primary Completion: December 31, 2018
• Study Completion: December 31, 2018
• Last Updated: January 18, 2019

Record last verified: 2019-01

Locations

GB (1)