Finding the Right Words in Neurogenic Communication Disorders

NCT03568760 | Completed

• 1 other identifier: 2016-01275
• Study Type: interventional
• Target: 17
• Locations: 1 country
• Sites: 1

Brief Summary

Every year thousands of persons suffer from brain damage resulting in anomia, that is, word finding difficulties affecting their ability to talk to other people. Anomia may be a result of stroke or of progressive neurological diseases such as Parkinson's disease or multiple sclerosis (MS). Word retrieval is dependent on a complex system of different neural networks and to name objects and activities can be affected to different degrees. The present project explores different aspects of naming ability in altogether 90 persons that has anomia related to stroke or to Parkinson's disease or MS. Furthermore, the communicative strategies and resources used by conversation partners in everyday conversational interaction and in care situations, affected by anomia are studied. Finally, the project includes a study of the effectiveness of a word finding training program based on stimulation of semantic and phonological networks in the brain, involved in the production of words. There is a lack of research on effects on communication from anomia in Parkinson's disease and MS and there is no research on anomia that investigates both object and action naming using a material adapted to the Swedish language. In the project quantitative and qualitative methods are used to explore and describe how persons with different neurogenic communication disorders can use different resources and communicative strategies to express themselves.

Conditions

Anomia; Stroke; Aphasia; Parkinson Disease; Multiple Sclerosis

Keywords

Anomia

Outcome Measures

Primary Outcomes (1)

• Naming ability in the Object & Action Naming Battery

  A measure of change in ability to name forty pictures consisting of simple black and white drawings. There is a 20-second time limit for response for each picture. Number of correct objects and activities will be calculated separately (range 0-20) as well as summarized (range 0-40)

  At baseline before start of intervention and after 21 days, at completion the intervention program

Secondary Outcomes (11)

• Sustained change in naming ability in the Object & Action Naming Battery

  At a twelve week follow up after the completion of the intervention

• Naming of 20 individually chosen training words

  At baseline before start of intervention and after 21 days, at completion the intervention program

• Sustained change in naming of 20 individually chosen training words

  At a twelve week follow up after the completion of the intervention

• The Communication Outcome After Stroke (COAST) scale

  At baseline before start of intervention and after 21 days, at completion the intervention program

• Sustained change in the Communication Outcome After Stroke (COAST) scale

  At a twelve week follow up after the completion of the intervention

Study Arms (2)

SFA treatment

EXPERIMENTAL

Semantic feature analysis

Behavioral: Semantic feature analysis

Comprehension training

PLACEBO COMPARATOR

Comprehension training

Behavioral: Comprehension training

Interventions

Semantic feature analysis BEHAVIORAL

Confrontation naming training and training in doing circumlocutions

SFA treatment

Comprehension training BEHAVIORAL

Reading and hearing comprehension

Comprehension training

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Subjective experience of word finding difficulties
• Diagnosed left hemisphere stroke or Parkinson's disease or MS
• With correction, sufficient hearing and vision to be able to participate in the assessment
• Participants with stroke at least six months post-onset and documented location of injury.

You may not qualify if:

• Mother tongue other than Swedish
• Moderately or severely impaired comprehension
• Other neurological injury or disease
• Moderate-severe apraxia of speech or dysarthria
• Fatigue or impaired attention deficit which prevents participating in intensive training

Sponsors & Collaborators

• Göteborg University: lead
• The Swedish Research Council: collaborator
• Swedish Council for Working Life and Social Research: collaborator

Study Sites (1)

University of Gothenburg

Gothenburg, Västra Göraland, 405 30, Sweden

Location

Related Publications (4)

• Tallberg IM, Ivachova E, Jones Tinghag K, Ostberg P. Swedish norms for word fluency tests: FAS, animals and verbs. Scand J Psychol. 2008 Oct;49(5):479-85. doi: 10.1111/j.1467-9450.2008.00653.x. Epub 2008 Apr 29.

  PMID: 18452499 BACKGROUND

• Long A, Hesketh A, Paszek G, Booth M, Bowen A. Development of a reliable self-report outcome measure for pragmatic trials of communication therapy following stroke: the Communication Outcome after Stroke (COAST) scale. Clin Rehabil. 2008 Dec;22(12):1083-94. doi: 10.1177/0269215508090091.

  PMID: 19052247 BACKGROUND

• Baylor C, Yorkston K, Eadie T, Kim J, Chung H, Amtmann D. The Communicative Participation Item Bank (CPIB): item bank calibration and development of a disorder-generic short form. J Speech Lang Hear Res. 2013 Aug;56(4):1190-208. doi: 10.1044/1092-4388(2012/12-0140). Epub 2013 Jul 1.

  PMID: 23816661 BACKGROUND

• Hilari K, Lamping DL, Smith SC, Northcott S, Lamb A, Marshall J. Psychometric properties of the Stroke and Aphasia Quality of Life Scale (SAQOL-39) in a generic stroke population. Clin Rehabil. 2009 Jun;23(6):544-57. doi: 10.1177/0269215508101729. Epub 2009 May 15.

  PMID: 19447841 BACKGROUND

MeSH Terms

Conditions

Anomia; Stroke; Aphasia; Parkinson Disease; Multiple Sclerosis

Condition Hierarchy (Ancestors)

Language Disorders; Communication Disorders; Neurobehavioral Manifestations; Neurologic Manifestations; Nervous System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases; Speech Disorders; Parkinsonian Disorders; Basal Ganglia Diseases; Movement Disorders; Synucleinopathies; Neurodegenerative Diseases; Demyelinating Autoimmune Diseases, CNS; Autoimmune Diseases of the Nervous System; Demyelinating Diseases; Autoimmune Diseases; Immune System Diseases

Study Officials

• Charlotta Saldert

  Inst of Neurosci & Physiology, Speech & Language Pathology Unit University of Gothenburg

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Masking Details: The results are assessed by independent assessors blinded to when the data is obtained and from which group.
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 21, 2018
• First Posted: June 26, 2018
• Study Start: January 1, 2016
• Primary Completion: December 31, 2021
• Study Completion: December 31, 2021
• Last Updated: March 16, 2022

Record last verified: 2022-03

Data Sharing

• IPD Sharing: Will not share

Locations

SE (1)