Home-Based HIT in Obese Individuals

NCT03557736 | Completed

• 1 other identifier: Home-HIT
• Study Type: interventional
• Target: 32
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to investigate the efficacy of a novel home-based high-intensity interval training (Home-HIT) intervention in obese individuals, with elevated cardiovascular disease (CVD) risk. It was hypothesised that Home-HIT would 1) have high adherence to the prescribed exercise intensity (compliance), 2) improve markers of CVD risk, and 3) lead to favourable skeletal muscle adaptations.

Conditions

Obese

Outcome Measures

Primary Outcomes (2)

• change in aerobic fitness

  change in maximal aerobic capacity following the training

  change in baseline aerobic fitness at 12 weeks

• Adherence and compliance to the exercise training intervention

  Session completion rate (adherence) and ability to meet target heart rates (compliance)

  adherance and compliance to the training over the 12 weeks

Secondary Outcomes (3)

• change in baseline FMD

  change in baseline FMD at 12 weeks

• change in vascular stiffness

  change in baseline vascular stiffness at 12 weeks

• change in body fat percentage

  chage in baseline body fat percentage at 12 weeks

Study Arms (3)

Home-HIT

EXPERIMENTAL

Home-based high-intensity interval training: participants performed 12 weeks of simple body weight exercises in a place of their own choosing 3x/week

Behavioral: Training mode

Home-MICT

EXPERIMENTAL

Home-based moderate-intensity interval training: participants performed 12 weeks of continuous exercise (running, swimming or cycling) in a place of their own choosing 3x/week

Behavioral: Training mode

Lab-HIT

EXPERIMENTAL

Laboratory-based high-intensity interval training: participants performed supervised cycle exercise under laboratory conditions 3x/week for 12 weeks

Behavioral: Training mode

Interventions

Training mode BEHAVIORAL

type of exercise training completed for 12 weeks

Home-HIT; Home-MICT; Lab-HIT

Eligibility Criteria

• Age: 18 Years - 55 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• obesity (BMI \>30 kg/m2)
• age 18-55

You may not qualify if:

• diagnosed CVD and other contraindications to participate in an exercise intervention
• BMI \<30 kg/m2

Sponsors & Collaborators

• Liverpool John Moores University: lead

Study Sites (1)

Liverpool John Moores University

Liverpool, Merseyside, L3 3AF, United Kingdom

Location

Related Publications (1)

• Scott SN, Shepherd SO, Hopkins N, Dawson EA, Strauss JA, Wright DJ, Cooper RG, Kumar P, Wagenmakers AJM, Cocks M. Home-hit improves muscle capillarisation and eNOS/NAD(P)Hoxidase protein ratio in obese individuals with elevated cardiovascular disease risk. J Physiol. 2019 Aug;597(16):4203-4225. doi: 10.1113/JP278062. Epub 2019 Jul 15.

  PMID: 31218680 DERIVED

MeSH Terms

Conditions

Obesity

Condition Hierarchy (Ancestors)

Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Dr Sam Shepherd

Study Record Dates

• First Submitted: May 9, 2018
• First Posted: June 15, 2018
• Study Start: March 9, 2015
• Primary Completion: July 15, 2017
• Study Completion: January 30, 2018
• Last Updated: June 15, 2018

Record last verified: 2018-06

Data Sharing

• IPD Sharing: Will not share

Locations

GB (1)