Changes in Intrahepatic Lipids With Exercise

NCT02181270 | Completed

• 1 other identifier: IHEEX
• Study Type: interventional
• Target: 57
• Locations: 1 country
• Sites: 1

Brief Summary

Individuals with obesity and particular type 2 diabetes have abnormally high levels of fat in liver cells and are at increased risk for cardiovascular and liver-related mortality. Prior research has shown that caloric restriction, exercise, and behavior modification can help lower hepatic fat levels in these individuals. Additional research has also shown that exercise independent of weight loss can reduce hepatic fat content in obese humans. The current exercise guidelines do not specify what type or what intensity of exercise is required to induce such reductions in hepatic fat. Thus, the purpose for doing this study is to determine if there are differential effects on liver fat with 4 wk of high intensity intermittent exercise compared with continuous moderate exercise in obese individuals.

Conditions

Obese

Keywords

NAFLD; obesity; ck18; blood lipids; high intensity exercise training; individuals; >5% liver fat

Outcome Measures

Primary Outcomes (1)

• percent of intrahepatic fat as measured by magnetic resonance spectroscopy

  6 weeks

Secondary Outcomes (1)

• plasma cytokeratin 18 (ck18) units: (U/I)

  6 weeks

Other Outcomes (1)

• blood measures of blood lipids (triglycerides, cholesterol, high density lipoproteins (HDL) )

  6 weeks

Study Arms (2)

high intensity exercise

EXPERIMENTAL

High-intensity interval exercise (HIIE): Subjects will perform 5-10 minute warm-up (50% VO2peak). Subjects will then exercise at an exercise intensity that corresponds to 90% HRmax, for 4 minutes. This will be followed by 3 min of exercise at 55% HRmax. Four of these exercise intervals/recovery periods will be completed. The total exercise commitment will be \~45 minutes

Other: high intensity exercise

Continuous moderate exercise group

EXPERIMENTAL

Continuous moderate exercise group (CME): Subjects will perform a 5-10 minute warm-up at 50% VO2peak. Thereafter, the intensity of exercise will be increased to 70% VO2peak by increasing the speed and incline of the treadmill. Subjects will exercise at this intensity for 60 minutes.

Other: continuous moderate exercise

Interventions

high intensity exercise OTHER

Subjects will perform 5-10 minute warm-up (50% VO2peak). Subjects will then exercise at an exercise intensity that corresponds to 90% HRmax, for 4 minutes. This will be followed by 3 min of exercise at 55% HRmax. Four of these exercise intervals/recovery periods will be completed. The total exercise commitment will be \~45 minutes

high intensity exercise

continuous moderate exercise OTHER

Subjects will perform a 5-10 minute warm-up at 50% VO2peak. Thereafter, the intensity of exercise will be increased to 70% VO2peak by increasing the speed and incline of the treadmill. Subjects will exercise at this intensity for 60 minutes.

Continuous moderate exercise group

Eligibility Criteria

• Age: 21 Years - 60 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Overweight or obese with a body mass index between 30-45 kg/m2.
• No known cardiovascular, kidney, or liver disease.
• No extreme hypertension (\>160 mm Hg systolic and/or \> 100 mm Hg diastolic).
• Not being treated with exogenous insulin.
• No history of surgery for weight loss and weight stable for prior 3 months (weight change \< 3 kg).
• Non-exerciser (\< 20 minutes of exercise 2 days per week).
• Between 21-60 yr of age

You may not qualify if:

• History of alcohol use (\> 20 g/day for males and \> 10 g/day for females)
• Kidney or liver disease.
• Extreme hypertension \>160 mm Hg systolic and/or \> 100 mm Hg diastolic.
• Waist measurement greater than 60"
• Magnetic Resonance Spectroscopy scan with less than 5% of liver fat
• A history of surgery for weight loss.
• Exerciser (\>20 minutes of exercise at least 2 days per week)
• Pregnant or lactating
• \<21 or \>60 yr of age

Sponsors & Collaborators

• University of Missouri-Columbia: lead

Study Sites (1)

University of Missouri

Columbia, Missouri, 65211, United States

Location

Related Publications (1)

• Winn NC, Liu Y, Rector RS, Parks EJ, Ibdah JA, Kanaley JA. Energy-matched moderate and high intensity exercise training improves nonalcoholic fatty liver disease risk independent of changes in body mass or abdominal adiposity - A randomized trial. Metabolism. 2018 Jan;78:128-140. doi: 10.1016/j.metabol.2017.08.012. Epub 2017 Sep 20.

  PMID: 28941598 DERIVED

MeSH Terms

Conditions

Obesity; Non-alcoholic Fatty Liver Disease

Interventions

High-Intensity Interval Training

Condition Hierarchy (Ancestors)

Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Fatty Liver; Liver Diseases; Digestive System Diseases

Intervention Hierarchy (Ancestors)

Physical Conditioning, Human; Exercise; Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Jill Kanaley, PhD

  University of Missouri-Columbia

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: professor

Study Record Dates

• First Submitted: June 30, 2014
• First Posted: July 3, 2014
• Study Start: October 1, 2013
• Primary Completion: June 1, 2017
• Study Completion: June 1, 2017
• Last Updated: January 23, 2018

Record last verified: 2018-01

Locations

US (1)