HIT in People With Type 1 Diabetes

NCT03545841 | Completed

• 1 other identifier: T1D_PARTB
• Study Type: interventional
• Target: 14
• Locations: 1 country
• Sites: 1

Brief Summary

Few people with type 1 diabetes achieve exercise guidelines and many programmes designed to increase physical activity have failed. High-intensity interval training (HIT) has been shown to be a time-efficient alternative to traditional moderate-intensity continuous training (MICT) in various groups without type 1 diabetes. A single bout of HIT does not increase the risk of hypoglycaemia in people with type 1 diabetes. This study aimed to assess whether HIT a safe, effective and time-efficient training strategy to improve cardio-metabolic health and reduce the risk of hypoglycaemia in people with type 1 diabetes.

Conditions

Type1diabetes

Outcome Measures

Primary Outcomes (1)

• Maximal aerobic capacity

  Maximal aerobic capacity test pre and post 6-week training intervention

  change in baseline maximal aerobic capacity at 6 weeks

Secondary Outcomes (1)

• Vascular stiffness

  change in baseline vascular stiffness at 6 weeks

Study Arms (2)

HIT training

EXPERIMENTAL

6 weeks of high-intensity interval training (HIT)

Other: HIT

Moderate intensity training

EXPERIMENTAL

6 weeks of moderate-intensity continuous training (MICT)

Other: MICT

Interventions

HIT OTHER

Participants completed 6 weeks of HIT

HIT training

MICT OTHER

Participants completed 6 weeks of MICT

Moderate intensity training

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• duration of type 1 diabetes \>6 months
• basal bolus regimen
• no significant history of hyper- or hypoglycaemia (determined from medical history)

You may not qualify if:

• duration of type 1 diabetes \<6 months,
• insulin pump therapy
• significant history of hyper- or hypoglycaemia (determined from medical history)
• obesity (BMI \>30 kg∙m-2)
• pregnancy or planning pregnancy
• uncontrolled hypertension (\>180/100 mmHg)
• angina, autonomic neuropathy
• taking any medication that affects heart rate
• major surgery planned within 6 weeks of the study
• severe nonproliferative
• unstable proliferative retinopathy

Sponsors & Collaborators

• Liverpool John Moores University: lead

Study Sites (1)

Liverpool John Moores University

Liverpool, Merseyside, L3 3AF, United Kingdom

Location

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Dr Sam Shepherd, Principle Investigator

Study Record Dates

• First Submitted: May 9, 2018
• First Posted: June 4, 2018
• Study Start: March 9, 2015
• Primary Completion: October 10, 2017
• Study Completion: October 10, 2017
• Last Updated: June 4, 2018

Record last verified: 2018-06

Data Sharing

• IPD Sharing: Will not share

Locations

GB (1)