NCT03544684

Brief Summary

This study aims to compare the effect of a bout of high-intensity interval training (HIT) with a bout of moderate-intensity continuous training (MICT) on glucose concentrations over the subsequent 24h period.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
14

participants targeted

Target at below P25 for not_applicable

Timeline
Completed

Started Mar 2015

Typical duration for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

March 9, 2015

Completed
2.6 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

October 10, 2017

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

October 10, 2017

Completed
7 months until next milestone

First Submitted

Initial submission to the registry

May 9, 2018

Completed
26 days until next milestone

First Posted

Study publicly available on registry

June 4, 2018

Completed
Last Updated

June 11, 2018

Status Verified

June 1, 2018

Enrollment Period

2.6 years

First QC Date

May 9, 2018

Last Update Submit

June 7, 2018

Conditions

Type1diabetes

Outcome Measures

Primary Outcomes (1)

  • 24 hour glycaemic profile

    Continuous glucose monitoring will be used to assess the effects of an acute bout of fasted high intensity interval training or moderate intensity continuous training on 24 hour glycaemic profile.

    24 hours

Study Arms (3)

Control day with no exercise

EXPERIMENTAL

glycaemic profile will be assessed using continuous glucose monitors following a single 24-hour period in which participants performed no exercise

Behavioral: Effects of the type of exercise on blood glucose concentrations

High intensity interval training (HIT)

EXPERIMENTAL

glycaemic profile will be assessed using continuous glucose monitors following a 24-hour period whereby participants performed a single bout of high-intensity interval training (HIT) in the morning under fasted conditions

Behavioral: Effects of the type of exercise on blood glucose concentrations

moderate intensity continuous training (MICT)

EXPERIMENTAL

glycaemic profile will be assessed using continuous glucose monitors following a 24-hour period whereby participants performed a single bout of moderate-intensity continuous training (MICT) in the morning under fasted conditions

Behavioral: Effects of the type of exercise on blood glucose concentrations

Interventions

Effects of the type of exercise on blood glucose concentrationsBEHAVIORAL

glucose concentrations were assessed over the 24 hour periods following no exercise, a single bout of high intensity interval training and a single bout of moderate intensity continuous training

Control day with no exerciseHigh intensity interval training (HIT)moderate intensity continuous training (MICT)

Eligibility Criteria

Age18 Years - 55 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • duration of type 1 diabetes \>6 months
  • basal bolus regimen
  • no significant history of hyper- or hypoglycaemia (determined from medical history

You may not qualify if:

  • duration of type 1 diabetes \<6 months,
  • insulin pump therapy
  • significant history of hyper- or hypoglycaemia (determined from medical history)
  • obesity (BMI \>30 kg∙m-2)
  • pregnancy or planning pregnancy, uncontrolled hypertension (\>180/100 mmHg)
  • angina
  • autonomic neuropathy
  • taking any medication that affects heart rate
  • major surgery planned within 6 weeks of the study
  • severe nonproliferative and
  • unstable proliferative retinopathy

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Liverpool John Moores University

Liverpool, Merseyside, L3 3AF, United Kingdom

Location

Related Publications (2)

  • Scott SN, Cocks M, Andrews RC, Narendran P, Purewal TS, Cuthbertson DJ, Wagenmakers AJM, Shepherd SO. High-Intensity Interval Training Improves Aerobic Capacity Without a Detrimental Decline in Blood Glucose in People With Type 1 Diabetes. J Clin Endocrinol Metab. 2019 Feb 1;104(2):604-612. doi: 10.1210/jc.2018-01309.

    PMID: 30281094DERIVED

  • Scott SN, Cocks M, Andrews RC, Narendran P, Purewal TS, Cuthbertson DJ, Wagenmakers AJM, Shepherd SO. Fasted High-Intensity Interval and Moderate-Intensity Exercise Do Not Lead to Detrimental 24-Hour Blood Glucose Profiles. J Clin Endocrinol Metab. 2019 Jan 1;104(1):111-117. doi: 10.1210/jc.2018-01308.

    PMID: 30252054DERIVED

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
BASIC SCIENCE
Intervention Model
CROSSOVER
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Lecturer/Senior Lecturer, Principle Investigator

Study Record Dates

First Submitted

May 9, 2018

First Posted

June 4, 2018

Study Start

March 9, 2015

Primary Completion

October 10, 2017

Study Completion

October 10, 2017

Last Updated

June 11, 2018

Record last verified: 2018-06

Data Sharing

IPD Sharing
Will not share

There is no plan to make individual data available to others

Locations

GB(1)