Combined Diagnosis of CT and Exosome in Early Lung Cancer
1 other identifier
observational
80
0 countries
N/A
Brief Summary
This experiment has now collected 50 cases, all through CT chest scans and blood exosome detection. Twenty-two patients underwent surgical treatment and 14 tissue specimens were examined for cancer and paracancerous tissue exosomesWe found that exosomal micor-A was highly expressed in early stage lung cancer tissues and was significantly higher than paracancerous tissues. The micor-A in the adjacent tissues was significantly higher than that in peripheral blood exosomes
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started May 2018
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
May 18, 2018
CompletedStudy Start
First participant enrolled
May 20, 2018
CompletedFirst Posted
Study publicly available on registry
May 31, 2018
CompletedPrimary Completion
Last participant's last visit for primary outcome
May 30, 2019
CompletedStudy Completion
Last participant's last visit for all outcomes
June 30, 2019
CompletedMay 31, 2018
May 1, 2018
1 year
May 18, 2018
May 18, 2018
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
exosome in cancer tissue and para cancerous tissue
exosomal micor-A was highly expressed in early stage lung cancer tissues
one year
Study Arms (17)
Age
Sex
triglyceride
Lipoprotein
CT
Target Reconstruction
micorRNA-A Plasma exocrine
micorRNA-A Paracancerous tiusse
pathologic diagnosis
hemolysis
ct-DNA
micorRNA-A in plasma
Sample quality control
positive
negative
micorRNA-R in plasma
micorRNA-R in Plasma exocrine
Surgery
Interventions
After surgical treatment, pathological specimens were extracted to obtain pathological results
Eligibility Criteria
From November 2017 to June 2019, there were nodules on the lungs, both men and women, and patients of the same age who had CT target reconstruction and miRNA and ctDNA detection at the same time had complete follow-up data.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Study Design
- Study Type
- observational
- Observational Model
- OTHER
- Time Perspective
- OTHER
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Combined diagnosis of CT and exosome in early lung cancer
Study Record Dates
First Submitted
May 18, 2018
First Posted
May 31, 2018
Study Start
May 20, 2018
Primary Completion
May 30, 2019
Study Completion
June 30, 2019
Last Updated
May 31, 2018
Record last verified: 2018-05