A Study to Explore Clinical Characteristics and Prognoses of N2 Patients With Non-small Cell Lung Cancer
A Multi-centre Real-world Non-interventional Observational Study to Explore Clinical Characteristics of Lymph Skip Metastases and Prognoses of N2 Patients With Non-small Cell Lung Cancer
1 other identifier
observational
2,653
1 country
9
Brief Summary
A study to compare patient survivals in the N2 patients with non-small cell lung cancer in the subgroups of lymph skip metastases and non-skip metastases
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Dec 2017
Shorter than P25 for all trials
9 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
December 1, 2017
CompletedFirst Submitted
Initial submission to the registry
February 5, 2018
CompletedFirst Posted
Study publicly available on registry
February 12, 2018
CompletedPrimary Completion
Last participant's last visit for primary outcome
March 30, 2018
CompletedStudy Completion
Last participant's last visit for all outcomes
March 30, 2018
CompletedMay 21, 2018
May 1, 2018
4 months
February 5, 2018
May 18, 2018
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Difference in overall survival (OS)
OS difference in the subgroups of N2 patients with lymph skip metastases and non-skip metastases
2014 - 2017
Secondary Outcomes (1)
Percentage of N2 patients with lymph skip metastases
2014 - 2017
Other Outcomes (2)
Difference in overall survival (OS) (in the subgroups of patients)
2014 - 2017
Hazard factors of overall survival
2014 - 2017
Study Arms (1)
N2 non-small cell lung cancer
Chinese patients with N2 non-small cell lung cancer
Interventions
Eligibility Criteria
Pathologically diagnosed Chinese NSCLC patients with chest surgeries and lymphadenectomy
You may qualify if:
- Patients with surgeries from 2014 to 2017;
- Pathologically diagnosed patients with non-small cell lung cancer;
- Age \> 18 years old;
- Patients with chest surgeries before hospitalization;
- Patients with N2 lymph nodes (+) after surgeries who received lymphadenectomy (Group 10 and 11 lymph nodes);
You may not qualify if:
- \- Patients with radiotherapies, chemotherapies and biological therapies for tumors
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Tianjin Chest Hospitallead
- LinkDoc Technology (Beijing) Co. Ltd.collaborator
Study Sites (9)
China-Japan Friendship Hospital
Beijing, Beijing Municipality, 100029, China
China People's Liberation Army Hospital
Beijing, Beijing Municipality, 100853, China
Henan Cancer Hospital
Zhengzhou, Henan, 450008, China
Tongji Hospital Affiliated to Huaxi Technology University
Wuhan, Hubei, 430030, China
Jiangsu Cancer Hospital
Nanjing, Jiangsu, 210009, China
Shanghai Chest Hospital
Shanghai, Shanghai Municipality, 200030, China
Xi'an Tangdu Hospital
Xi'an, Shanghai Municipality, 710000, China
Huaxi Hospital Affiliate to Sichuan University
Chengdu, Sichuan, 610041, China
First Hospital Affiliated to Zhejiang University
Hangzhou, Zhejiang, 310003, China
Related Publications (1)
Li X, Li X, Fu X, Liu L, Liu Y, Zhao H, Li Y, Hu J, Xu L, Liu D, Yang H, Zhang X. Survival benefit of skip metastases in surgically resected N2 non-small cell lung cancer: A multicenter observational study of a large cohort of the Chinese patients. Eur J Surg Oncol. 2020 Oct;46(10 Pt A):1874-1881. doi: 10.1016/j.ejso.2019.12.015. Epub 2019 Dec 18.
PMID: 31902592DERIVED
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Xun Zhang, PhD
Tianjin Chest Hospital
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- RETROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Professor
Study Record Dates
First Submitted
February 5, 2018
First Posted
February 12, 2018
Study Start
December 1, 2017
Primary Completion
March 30, 2018
Study Completion
March 30, 2018
Last Updated
May 21, 2018
Record last verified: 2018-05
Data Sharing
- IPD Sharing
- Will not share